Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid

Bramos, Athanasios; Perrault, David; Yang, Sara; Jung, Eunson; Hong, Young Kwon; Wong, Alex K.

doi:10.1097/sla.0000000000001525

Cited by 32 publications

(37 citation statements)

References 40 publications

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“…Surgery in combination with irradiation is commonly applied for the induction of chronic lymphedema in animals 7 22 . Nonetheless, approaches inducing acute lymphatic damage without irradiation have been used for the study of vascularized lymph node transfer and growth factor treatment 27 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Many researches use conventional techniques to estimate the rodent hindlimb volume when reporting outcomes of experimental lymphedema treatment. Common parameters are the assessment of water displacement 36 , circumferential length 37 38 39 or paw thickness 7 19 . Importantly, while well established in human lymphology 40 , water displacement has been shown to yield inaccurate measurements in the mouse-tail model 41 .…”

Section: Discussionmentioning

confidence: 99%

“…The caliper represents an inexpensive and simple tool for the assessment of rodent paw thickness. It has been used as a surrogate parameter for hindlimb volume in experimental lymphedema research 7 19 , but its eligibility for this purpose has not been specifically analyzed. Planimetry as well as the measurement of circumferential length and paw thickness showed high interobserver correlations.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, acquired damage of collecting lymphatic vessels causes secondary lymphedema. In the United States, more than 5 million people suffer from cancer-related lymphedema 7 , the most common form in developed countries. Lymph node dissection and irradiation result in the formation of scar tissue, which is a key inhibitor of lymphatic regeneration 8 .…”

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confidence: 99%

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High-resolution 3D volumetry versus conventional measuring techniques for the assessment of experimental lymphedema in the mouse hindlimb

Frueh

Körbel

Gassert

et al. 2016

Sci Rep

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Secondary lymphedema is a common complication of cancer treatment characterized by chronic limb swelling with interstitial inflammation. The rodent hindlimb is a widely used model for the evaluation of novel lymphedema treatments. However, the assessment of limb volume in small animals is challenging. Recently, high-resolution three-dimensional (3D) imaging modalities have been introduced for rodent limb volumetry. In the present study we evaluated the validity of microcomputed tomography (μCT), magnetic resonance imaging (MRI) and ultrasound in comparison to conventional measuring techniques. For this purpose, acute lymphedema was induced in the mouse hindlimb by a modified popliteal lymphadenectomy. The 4-week course of this type of lymphedema was first assessed in 6 animals. In additional 12 animals, limb volumes were analyzed by μCT, 9.4 T MRI and 30 MHz ultrasound as well as by planimetry, circumferential length and paw thickness measurements. Interobserver correlation was high for all modalities, in particular for μCT analysis (r = 0.975, p < 0.001). Importantly, caliper-measured paw thickness correlated well with μCT (r = 0.861), MRI (r = 0.821) and ultrasound (r = 0.800). Because the assessment of paw thickness represents a time- and cost-effective approach, it may be ideally suited for the quantification of rodent hindlimb lymphedema.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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High-resolution 3D volumetry versus conventional measuring techniques for the assessment of experimental lymphedema in the mouse hindlimb

Frueh

Körbel

Gassert

et al. 2016

Sci Rep

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“…To mimic the lymphatic damage of clinical cancer treatment most precisely, we did not leave a skin gap, an otherwise popular experimental procedure in rodents for the prevention of spontaneous lymphatic reconnection. 35,36 Histopathological analyses 14 weeks after surgery revealed typical characteristics of chronic lymphedema, such as tissue fibrosis, immune cell infiltration, and an increase in lymphatic vessel density and area. In addition, hindlimb volumes estimated by paw thickness measurements were elevated in the lymphedema group throughout the 14-week observation period.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Lymphography at 9.4 T Using a Gadolinium-Based Nanoparticle in Rats

Müller¹,

Fries²,

Jelvani³

et al. 2017

Invest Radiol

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Lymphatic channel sheet of polydimethylsiloxane for preventing secondary lymphedema in the rat upper limb model

Cheon

Gelvosa

Kim

et al. 2022

Bioengineering & Transla Med

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Secondary lymphedema is a severe complication of cancer treatment, but there is no effective curative method yet. Lymph node dissection and radiation therapy for cancer treatment may lead to secondary lymphedema, which is a chronic disease induced by malfunction of lymphatic flow. The lymphatic channel sheet (LCS) is an artificial micro‐fluidic structure that was fabricated with polydimethylsiloxane to maintain lymphatic flow and induce lymphangiogenesis. The structure has two‐dimensional multichannels that increase the probability of lymphangiogenesis and allow for relatively easy application. We verified the efficacy of the lymphatic channel sheet through macroscopic and microscopic observation in small animal models, which underwent brachial lymph node dissection and irradiation. The lymphatic channel sheet enabled the successful transport of lymphatic fluid from the distal to the proximal area in place of the removed brachial lymph nodes. It prevented swelling and abnormal lymphatic drainage during the follow‐up period. Lymphangiogenesis was also identified inside the channel by histological analysis after 8 weeks. According to these experimental results, we attest to the roles of the lymphatic channel sheet as a lymphatic pathway and scaffold in the rat upper limb model of secondary lymphedema. The lymphatic channel sheet maintained lymphatic flow after lymph node dissection and irradiation in an environment where lymph flow is cut off. It also relieved symptoms of secondary lymphedema by providing a lymph‐friendly space and inducing lymphangiogenesis.

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Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid

Cited by 32 publications

References 40 publications

High-resolution 3D volumetry versus conventional measuring techniques for the assessment of experimental lymphedema in the mouse hindlimb

High-resolution 3D volumetry versus conventional measuring techniques for the assessment of experimental lymphedema in the mouse hindlimb

Magnetic Resonance Lymphography at 9.4 T Using a Gadolinium-Based Nanoparticle in Rats

Lymphatic channel sheet of polydimethylsiloxane for preventing secondary lymphedema in the rat upper limb model

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