Nanomedicine and Nanotoxicology: The Pros and Cons for Neurodegeneration and Brain Cancer

Catalán-Figueroa, Johanna; Palma-Florez, Sujey; Álvarez, Gonzalo; Fritz, H.; Jara, Miguel; Morales, Javier

doi:10.2217/nnm.15.189

Cited by 24 publications

(16 citation statements)

References 129 publications

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“…8,9,23 This may simply reflect cellspecific parameters of predisposition to QDs-GSH toxicity, as has been reported previously in different cell lines exposed to inorganic NPs. 33 Alternatively, it is well established that the generation of ROS represents one of the main mechanisms by which QDs induce damage to biological systems. [13][14][15]19 Intracellular thiols (RSH) play an important role as mediators of tolerance to intracellular ROS.…”

Section: Results and Discussion Synthesis And Characterization Of Qdsmentioning

confidence: 99%

“…34 Therefore, we hypothesized that NAC should ameliorate detrimental QDs-GSH effects on metastatic cells, given that NAC increases intracellular RSH levels. 17 Moreover, NAC is generally beneficial and protects cells against organic stress induced by inorganic NPs, 33 as well as provides greater protection against QDs damage than other non-thiol anti-oxidants, such as trolox. 30 Given our results showing that incubation of cells with 100 µg/mL of rQDs-GSH resulted in .80% viable labeled cells, similar to the percentage of viable labeled cells reported by Voura et al, 12 with the best mean MFI values ( Figure 1C and D), as well as the fact that fluorescence emission at longer wavelengths is absorbed to a lesser extent by tissues, 4 we focused on characterizing the behavior of B16F10 cells after labeling with 100 µg/mL rQDs-GSH.…”

Section: Nac Treatment Reduces Rqds-gsh Effects In B16f10 Cells and Imentioning

confidence: 99%

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Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Díaz-García¹,

Guerrero²,

Díaz-Valdivia³

et al. 2018

IJN

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BackgroundNumerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in biological systems and little is known about whether QDs affect the capacity of cancer cells to metastasize. Previously, we described the “biomimetic” synthesis of CdTe-QDs (QDs-glutathione [GSH]) with increased biocompatibility and the potential utility in labeling cells.PurposeIn order to determine the feasibility of using QDs-GSH as a tool for tracking tumor cells during early metastasis, we characterized here for the first time, the in vitro and in vivo effects of the incorporation of green or red biomimetic QDs-GSH into B16F10 cells, a syngeneic mouse melanoma line for metastasis assays in C57BL/6 mice.MethodsB16F10 cells were labeled with green or red biomimetic QDs-GSH in the presence or absence of n-acetylcysteine. Then, migration, invasion and proliferation of labeled B16F10 were evaluated in vitro. Finally, the B16F10 cells labeled with red QDs-GSH were used to monitor in vivo lung metastasis at early time points (5 minutes to 24 hours) or after 21 days in C57BL/6 mice.ResultsWe developed a methodology that allows obtaining QDs-GSH-labeled B16F10 cells (nearly 100% viable labeled cells), which remained viable for at least 5 days and migrated similarly to control cells. However, proliferation, invasion, and the capacity to form metastatic nodules in the lungs were severely attenuated. Fluorescence imaging revealed that distribution/accumulation of QDs-GSH-labeled B16F10 cells could be tracked following injection into C57BL/6 mice (syngeneic preclinical metastasis model) and that these cells preferentially accumulated in the perialveolar area in lungs as early as 5 minutes post-injection.ConclusionThe methodology described here represents a useful alternative for monitoring initial events during tumor cell metastasis.

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Section: Results and Discussion Synthesis And Characterization Of Qdsmentioning

confidence: 99%

Section: Nac Treatment Reduces Rqds-gsh Effects In B16f10 Cells and Imentioning

confidence: 99%

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Díaz-García¹,

Guerrero²,

Díaz-Valdivia³

et al. 2018

IJN

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“…On one hand, the Cerense ® technology utilizes short-chain oligoglycerophospholipids that can transiently open the BBB tight junctions and facilitate the drug transport. On the other hand, the G-Technology comprises liposomes coated with polyethylene glycol and covered with glutathione to facilitate drug transport across the BBB through receptor-mediated transcytosis [130].…”

Section: Nanomedicine In Central Nervous System Disordersmentioning

confidence: 99%

Neuronanomedicine: An Up-to-Date Overview

et al. 2019

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The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood–brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented.

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“…Advances in the use of gold-based NMs for nanomedicine applications need to be followed by parallel bio-distribution and toxicity studies with maximum care and accuracy to guarantee their success. 114, 115, 129, 162–164…”

Section: Gold Nanomaterialsmentioning

confidence: 99%

Redox-active nanomaterials for nanomedicine applications

et al. 2017

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Nanomedicine utilizes the remarkable properties of nanomaterials for the diagnosis, treatment, and prevention of disease. Many of these nanomaterials have been shown to have robust antioxidative properties, potentially functioning as strong scavengers of reactive oxygen species. Conversely, several nanomaterials have also been shown to promote the generation of reactive oxygen species, which may precipitate the onset of oxidative stress, a state that is thought to contribute to the development of a variety of adverse conditions. As such, the impacts of NMs on biological entities are often associated with and influenced by their specific redox properties. In this review, we overview several classes of nanomaterials that have been or projected to be used across a wide range of biomedical applications, with discussion focusing on their unique redox properties. Amongst the nanomaterials examined include iron, cerium, and titanium metal oxide nanoparticles, gold, silver, and selenium nanoparticles, and various nanoscale carbon allotropes such as graphene, carbon nanotubes, fullerenes, and their derivatives/variations. Principal topics of discussion include the chemical mechanisms by which the nanomaterials directly interact with biological entities and the biological cascades that are thus indirectly impacted. Selected case studies highlighting the redox properties of nanomaterials and how they affect biological responses are used to exemplify the biologically-relevant redox mechanisms for each of the described nanomaterials.

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Nanomedicine and Nanotoxicology: The Pros and Cons for Neurodegeneration and Brain Cancer

Cited by 24 publications

References 129 publications

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Neuronanomedicine: An Up-to-Date Overview

Redox-active nanomaterials for nanomedicine applications

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