A luminescent europium(<scp>iii</scp>)–platinum(<scp>ii</scp>) heterometallic complex as a theranostic agent: a proof-of-concept study

The design of more efficient anticancer drugs requires a deeper understanding of their biodistribution and mechanism of action. Cell imaging agents could help to gain insight into biological processes and, consequently, the best strategy for attaining suitable scaffolds in which both biological and imaging properties are maximized. A new concept arises in this field that is the combination of two metal fragments as collaborative partners to provide the precise emissive properties to visualize the cell as well as the optimum cytotoxic activity to build more potent and selective chemotherapeutic agents.

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“…Ln III -Pt II heterobimetallic complexes. [39,40] Reproduced withp er-missionofT he RoyalS ocietyofC hemistry. Figure 10.…”

Section: Advantages and Optimization Processmentioning

confidence: 99%

Heterobimetallic Complexes for Theranostic Applications

Fernández‐Moreira

Gimeno

2018

Chemistry A European J

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“…Luminescence of Ln complexes, originating from the f–f transition, is promising for use in bio‐imaging, luminescent sensors, and optical devices because of the relatively long lifetime and high quantum yield. Therefore new ligands, which act as antennas, are needed for efficient energy transfer to Ln ions; for Ln emission.…”

Section: Figurementioning

confidence: 99%

Multiple Magnetic Relaxation Pathways and Dual‐Emission Modulated by a Heterometallic Tb‐Pt Bonding Environment

Yoshida

Izougu

Iwasawa

et al. 2017

Chemistry A European J

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A heterometallic Tb-Pt complex, [Tb Pt (SAc) (H O) ] (SAc=thioacetate), was synthesized. Dual emission was modulated by the presence of a heterometallic Tb-Pt bonding environment. The heterometallic Tb-Pt bond lowers the symmetry of the Tb ion and enhanced the emission efficiency. In addition, the Tb-Pt complex shows field-induced multiple magnetic relaxation pathways. Furthermore, it served as an antenna for the observed dual emission. In other words, the heterometallic Tb-Pt bond has a significant effect on the luminescence and magnetic properties of the complex.

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“…[50] The high cytotoxicity upon UV--irradiation (λexc = 365 nm) suggested the potential use of the complex as a ROS generator. Although the stability of the complex with respect to metal dissociation was improved compared to the parent [Eu.30] system, a more stable complex, [Eu.33], was presented by the same group [51] as a 'theranostic' agent, featuring a multidentate DTPA--bisamide ligand bearing two quinoline moieties that coordinate [PtCl2DMSO] units to provide the DNA binding of the complex. Isothermal titration calorimetry measurements, following addition of CT--DNA, revealed a two--step binding process presumably involving sequential intercalation of two platinum--containing moieties into DNA.…”

Section: Dna Recognition Using Intercalating Agentsmentioning

confidence: 99%

Responsive, Water‐Soluble Europium(III) Luminescent Probes

Shuvaev

Starck

Parker

2017

Chemistry A European J

112

103

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Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. E-mail: david.parker@dur.ac.uk; sergey.shuvaev@dur.ac.uk Abstract: The design principles, mechanism of action and performance of europium(III) complexes that serve as strongly emissive and responsive molecular probes in water are critically discussed. Examples of systems designed to assess pH, selected metal ions and anions, including chiral species, as well as selected small molecules and biopolymers are considered, and prospects evaluated for improved performance in more complex biological media such as in bio--fluids and within living cells. Modulation of the emission spectral form, lifetime and degree of circular polarisation can be used to quantify the spectral response and permit calibration. IntroductionThe genesis of lanthanide bio--imaging probes can be traced to two discoveries: the observation of the red emission of europium by Crookes in 1885 and the report of its sensitised emission made by Weissman in 1942 [1] . Each discovery epitomises the advantageous optical features of lanthanide complexes - narrow bands in emission with energies only slightly affected by the nature of the ligand, and a large separation (a "pseudo--Stokes' shift") between the absorbing (ligand--antenna) and emitting (lanthanide ion) photon energies. These favourable optical properties create a myriad of opportunities to devise responsive systems by judicious ligand design. Europium(III) complexes have particular advantages over other lanthanide complexes in biologically relevant applications: the higher transparency of biological tissue towards the red region of the visible spectrum; their high inherent brightness and low sensitivity to quenching by oxygen; the presence of three excited states ( 5 D2, 5 D1 and 5 D0) spanning the range 17500--21000 cm --1 that are lower in energy than the triplet levels of many different types of ligands; the presence of an environmentally insensitive magnetic--dipole transition 5 D0 to 7 F1 in the luminescence spectrum, (Figure 1), that can be used as an internal reference to the hypersensitive transition bands around 620 ( 5 D0 --7 F2) and 700 nm ( 5 D0 to 7 F4), and the high emission anisotropy factors, gem, in circularly polarised luminescence (CPL) spectra.

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A luminescent europium(iii)–platinum(ii) heterometallic complex as a theranostic agent: a proof-of-concept study

Abstract: We present a luminescent heterometallic multifunctional theranostic Eu–Pt2 complex, [{cis-PtCl2(DMSO)}2Eu(L)(H2O)], possessing two cytotoxic Pt-centers with four DNA-binding sites, which shows intracellular Eu-based red luminescence sensitized by platinum based MLCT excited states.

Cited by 57 publications

References 36 publications

Heterobimetallic Complexes for Theranostic Applications

Heterobimetallic Complexes for Theranostic Applications

Multiple Magnetic Relaxation Pathways and Dual‐Emission Modulated by a Heterometallic Tb‐Pt Bonding Environment

Responsive, Water‐Soluble Europium(III) Luminescent Probes

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