“…I G U R E 2 18 F-FDG PET/MR images of patient 3 Note the obvious hypometabolism, predominantly on the left side, without distinct atrophy in the bilateral frontal lobes (a, b), and severe, "blade-like" atrophy in the bilateral temporal lobes along with significant hypometabolism, especially in the anterior and lateral parts (c-h) mutations, c.1132A > G (p.N378D) and c.1147A > G (p.I383V), were identified in three patients.The frequency of TARDBP missense mutations in the current cohort was 0.77% (3/391), resembling previous results of 0.61% (1/165)(Huang et al, 2012), 0.93% (3/324)(Zou et al, 2016), 0.50% (1/200)(Ju et al, 2016), and 1.19% (3/253)(Chen et al, 2020), except for 4.76%…”