Diterpene alkaloids and diterpenes from Spiraea japonica and their anti-tobacco mosaic virus activity

Ma, Yuan; Mao, Xin-Ying; Huang, Liejun; Fan, Yi-Min; Gu, Wei; Yan, Chen; Huang, Tao; Zhang, Jianxin; Yuan, Chun‐Mao; Hao, Xiao‐Jiang

doi:10.1016/j.fitote.2015.11.019

Cited by 16 publications

(11 citation statements)

References 28 publications

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“…High inhibition rates (69-93%) were also observed from six terpenes derived from the ethanolic extracts of the whole plant of S. japonica (Ma et al, 2016). The spiramidine C2, a novel compound, was found to be effective in TMV control, as well as four other novel chemicals, (two atisinetype diterpene alkaloids and two atisane-type diterpenes) and other previously identified compounds.…”

Section: Natural Productsmentioning

confidence: 76%

Chemical Outbreak for Tobacco Mosaic Virus Control

Luvisi¹,

Panattoni²,

Materazzi³

et al. 2017

IJAB

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Tobacco mosaic virus (TMV) represents a paradigm in virology, and its control may open the way to effective treatment against phytoviruses. However, the use of chemicals to eliminate the virus from infected plants is very difficult. In this state of the art survey we include trials on a) natural compounds derived from organisms, b) synthetic compounds and c) plant or microorganism extracts, from 2006 to 2015. Plants have been the main source of natural products for anti-TMV tests in the last ten years, and Nicotiana tabacum was the main focus of research, particularly between 2014-2015. Since 2012, there has been a great increase in publications (+45%) and identified compounds (+241%). Between 2012-2015, an average of 31 papers were published and 140 compounds were tested each year, compared to 9 papers and 26 compounds in 2006-2011. Unfortunately, there is little information on the action mechanisms of newly discovered or modified compounds. Cross references to the basic structure of compounds is provided in this review. This chemical outbreak this massive interest in chemical solutions to TMV could be due to the increasing availability of instruments for the analysis of organic compounds. Alternatively Another explanation could be that the chemistry advances in synthesis, which have provided countless drugs with potential benefits for TMV control, have overwhelmed overloaded the plant pathology screening needed to discriminate between compounds and to provide useful agrochemicals for farmers.

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Section: Natural Productsmentioning

confidence: 76%

Chemical Outbreak for Tobacco Mosaic Virus Control

Luvisi¹,

Panattoni²,

Materazzi³

et al. 2017

IJAB

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“…Among 17 benzylphenethylamine alkaloids of five skeleton-types, 7-deoxy-trans-dihydronarciclasine (DDN) (Figure 7) was identified to be the most potent one in inhibiting TMV in the half-leaf method using ribavirin as the positive control (Wang et al, 2007a). Spiraea atisine-type alkaloids with an imine group at C-20, e.g., spirimine B (Figure 7), showed more potential anti-TMV activity than that of others and the positive control ningnamycin (Figure 7) (Ma et al, 2016). Two dozens of alkaloids were isolated from the roots of Stemona tuberosa.…”

Section: Miscellaneous Anti-tmv Plant Natural Products and Sar Inducersmentioning

confidence: 99%

Natural product sciences: an integrative approach to the innovations of plant natural products

Shen

Hao

2020

Sci. China Life Sci.

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The study on plant natural products not only helps us understand that their structural diversity is the inevitable result of plant species diversity, but also helps us understand certain rules and unity of the inevitable connection between the two. The diversity and complexity of chemical structures of many natural products are beyond imagination before we elucidated their structures. The question that follows is what is the biological significance of these natural products. Intrigued by the relationship between plant resources, natural products and biological functions, the Hao laboratory has taken an integrative approach that employs tools and knowledge from multi-disciplines, including natural product chemistry, chemical ecology and chemical biology, to unveil the effects of plant natural products on plant resistance to diseases, and environmental acclimations. Collaborating with cell biologists, the research has resulted in discovery of new mechanisms of cellular signaling and lead compounds.

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“…Whole plants of Spiraea japonica var. acuminata (Yunnan, China) contained five new diterpenes, among which spirimine B ( 430 ) and spiramilactone F ( 431 ) showed anti-TMV virus activities with protective/curative rates of 92.91%/41.30% and < 20%/69.40% at 100 μg/mL, respectively (ningnanmycin at 48.20%/50.72%) (Ma et al, 2016f ). Research into whole plants of Lavandula angustifolia (Yunnan, China) afforded three novel phenylpropanoids 432 - 434 with 33.9–38.4% inhibition on the TMV infection at 20 μM (ningnanmycin, 33.6%) (Tang et al, 2016a ).…”

Section: Terrestrial Plantsmentioning

confidence: 99%