Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis

Su, Fu Hsiung; Huang, Ya; Sung, Fung Chang; Su, Chien Tien; Hsu, Wen-Hwei; Chang, Shih Ni; Yeh, Chih Ching

doi:10.1016/j.vaccine.2015.10.129

Cited by 7 publications

(16 citation statements)

References 20 publications

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“…The effectiveness of influenza vaccine in preventing all-cause hospitalisation in patients with liver disease was investigated in two cohort studies, published in 2014 and 2016 24 25. A study of 408 participants from Japan24 investigated pandemic vaccine (against a single virus subtype) and enrolled exclusively patients with chronic hepatitis C virus (HCV) infection.…”

Section: Resultsmentioning

confidence: 99%

“…A study of 408 participants from Japan24 investigated pandemic vaccine (against a single virus subtype) and enrolled exclusively patients with chronic hepatitis C virus (HCV) infection. A study of 8080 participants from Taiwan25 investigated seasonal vaccine (against multiple virus subtypes) exclusively in patients with chronic hepatitis B virus (HBV) infection. In the study of patients with HCV infection, patients were prospectively recruited from those who were under clinical follow-up for their liver disease but vaccination status was self-reported 24.…”

Section: Resultsmentioning

confidence: 99%

“…In the study of patients with HCV infection, patients were prospectively recruited from those who were under clinical follow-up for their liver disease but vaccination status was self-reported 24. In the study of patients with HBV infection, both liver disease and vaccination status were determined from electronic medical claim records 25. One study presented results for one influenza season and the other for an entire year after vaccination and pooled the results from a period of 9 years (figure 5).…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

et al. 2019

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ObjectivesPatients with liver disease frequently require hospitalisation with infection often the trigger. Influenza vaccination is an effective infection prevention strategy in healthy and elderly but is often perceived less beneficial in patients with liver disease. We investigated whether influenza vaccination triggered serological response and prevented hospitalisation and death in liver disease.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, EMBASE, PubMed and CENTRAL up to January 2019.Eligibility criteriaRandomised or observational studies of the effects of influenza vaccine in adults with liver disease.Data extraction and synthesisTwo reviewers screened studies, extracted data and assessed risk of bias and quality of evidence. Primary outcomes were all-cause hospitalisation and mortality. Secondary outcomes were cause-specific hospitalisation and mortality, and serological vaccine response. Random-effects meta-analysis was used to estimate pooled effects of vaccination.ResultsWe found 10 041 unique records, 286 were eligible for full-text review and 12 were included. Most patients had viral liver disease. All studies were of very low quality. Liver patients both with and without cirrhosis mounted an antibody response to influenza vaccination, and vaccination was associated with a reduction in risk of hospital admission from 205/1000 to 149/1000 (risk difference −0.06, 95% CI −0.07 to 0.04) in patients with viral liver disease. Vaccinated patients were 27% less likely to be admitted to hospital compared with unvaccinated patients (risk ratio 0.73, 95% CI 0.66 to 0.80). No effect against all-cause or cause-specific mortality or cause-specific hospitalisation was found.ConclusionsThe low quantity and quality of the evidence means that the protective vaccine effect may be uncertain. Considering the high risk of serious health outcomes from influenza infection in patients with liver disease and the safety and low cost of vaccination, overall, the potential benefits of seasonal vaccination both to patients and the healthcare systems are likely to outweigh the costs and risks associated with vaccination.PROSPERO registration numberCRD42017067277.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

et al. 2019

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“…A prospective study of 311 persons with cirrhosis, 198 of whom received IIV3 and the remainder of whom were unvaccinated, noted reduction in the rates of ILI (14% versus 23%; p = 0.064) and of culture-positive influenza (2.3% versus 8.8%; p = 0.009) in the vaccinated group (215). Review of data from Taiwan's National Health Insurance program from 2000 through 2009 noted a lower hospitalization rate among persons with chronic hepatitis B infection who had been vaccinated compared with those who had not (16.29 versus 24.02 per 1,000 person-years) (216).…”

Section: Persons With Chronic Medical Conditionsmentioning

confidence: 98%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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“…The prevalence of HTLV-1 and HBV coinfection is high in certain indigenous Australian populations [41]. According to a population-based analysis [42], annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection. It implies that the influenza-target therapy may have some effect on HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis on multiple Gene Expression Omnibus datasets of the hepatitis B virus infection and its response to the interferon-alpha therapy

et al. 2020

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Background: Hepatitis B virus (HBV) infection is a global health problem and interferon-alpha (IFN-α) is one of the effective therapies. However, little is known about the genetic background of the HBV infection or the genetic determinants of the IFN-α treatment response. Thus, we aim to explore the possible molecular mechanisms of HBV infection and its response to the IFN-α therapy with a comprehensive bioinformatics analysis. Methods: The Gene Expression Omnibus datasets (GSE83148, GSE84044 and GSE66698) were collected and the differentially expressed genes (DEGs), key biological processes and intersecting pathways were analyzed. The expression of the co-expressed DEGs in the clinical samples was verified by quantitative real time polymerase chain reaction (qRT-PCR). Results: Analysis of all the 3 datasets revealed that there were eight up-regulated and one down-regulated coexpressed DEGs following the HBV infection and after IFN-α treatment. In clinical samples, the mRNA level of HKDC1, EPCAM, GSN, ZWINT and PLD3 were significantly increased, while, the mRNA level of PLEKHA2 was significantly decreased in HBV infected liver tissues compared to normal liver tissues. PI3K-Akt signaling pathway, focal adhesion, HTLV-I infection, cytokine-cytokine receptor interaction, metabolic pathways, NF-κB signaling pathway were important pathways associated with the HBV infection and the response of IFN-α treatment. Conclusions: The co-expressed genes, common biological processes and intersecting pathways identified in the study might play an important role in HBV infection and response of IFN-α treatment. The dysregulated genes may act as novel biomarkers and therapeutic targets for HBV.

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Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis

Cited by 7 publications

References 20 publications

Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

Prevention and Control of Seasonal Influenza with Vaccines

Bioinformatics analysis on multiple Gene Expression Omnibus datasets of the hepatitis B virus infection and its response to the interferon-alpha therapy

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