Sarcopénie et myopathie urémique : similitudes et différences

Chauveau, P.; Moreau, Karine; Lasseur, Catherine; Fouque, Denis; Combe, Christian; Aparicio, Michel

doi:10.1016/j.nephro.2015.08.002

Cited by 8 publications

(2 citation statements)

References 43 publications

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“…In our study, the low-moderate intensity of the program may have contributed to an increase in the proportion of slow fibers and in the size of the fast fibers, especially in the intercostal muscles as previously reported also in COPD patients [25]. Otherwise, changes in lung function in dialysis patients are well described [3], particularly a progressive deterioration of vital capacity, probably due to respiratory muscle weakness. We also observed, in a previous paper, a progressive decline in respiratory function in ESKD patients that was counteracted by an exercise program [5].…”

Section: Discussionsupporting

confidence: 80%

“…Chronic kidney disease (CKD) is responsible for a progressive alteration affecting skeletal muscles with a multifactorial etiology, including myocellular, immunologic and hormonal changes, metabolic acidosis, reduced protein intake and physical inactivity [1,2]. This condition, known as uremic myopathy, affects approximately 50% of patients on dialysis [3] and may lead to the development of sarcopenia [1], with impacts also on respiratory muscles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inspiratory–Expiratory Muscle Training Improved Respiratory Muscle Strength in Dialysis Patients: A Pilot Randomised Trial

Lamberti

Piva

Battaglia

et al. 2023

Advances in Respiratory Medicine

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End-stage kidney disease (ESKD) exposes patients to progressive physical deconditioning involving the respiratory muscles. The aim of this pilot randomized controlled trial was to determine the feasibility and effectiveness of low-intensity respiratory muscle training (RMT) learned at the hospital and performed at home. A group of ESKD patients (n = 22) were randomized into RMT or usual care (control group, CON) in a 1:1 ratio. The respiratory training was performed at home with an inspiratory–expiratory system for a total of 5 min of breathing exercises in a precise rhythm (8 breaths per minute) interspersed with 1 min of rest, two times per day on nondialysis days for a total of 4 weeks, with the air resistance progressively increasing. Outcome measures were carried out every 4 weeks for 3 consecutive months, with the training executed from the 5th to the 8th week. Primary outcomes were maximal inspiratory and expiratory pressure (MIP, MEP), while secondary outcomes were lung capacity (FEV1, FVC, MVV). Nineteen patients without baseline between-group differences completed the trial (T: n = 10; Age: 63 ± 10; Males: n = 12). Both MIP and MEP significantly improved at the end of training in the T group only, with a significant difference of MEP of 23 cmH2O in favor of the RMT group (p = 0.008). No significant variations were obtained for FVC, FEV1 or MVV in either group, but there was a greater decreasing trend over time for the CON group, particularly for FVC (t = −2.00; p = 0.046). Low-fatiguing home-based RMT, with a simple device involving both inspiratory and expiratory muscles, may significantly increase respiratory muscle strength.

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Section: Discussionsupporting

confidence: 80%