The importance of angiogenic markers in the differential diagnosis of HELLP syndrome vs. non-HELLP thrombocytopenia

Quirós, Covadonga; Suarez, Francisco; Prieto, Belén; Rodríguez,; Vaquerizo, Oscar; Fv, Álvarez Menéndez

doi:10.1515/cclm-2015-0890

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We included these three case reports, as they were clearly describing clinical encounters with patients in an acceptable case report format. 129 , 140 , 142 Finally, only a fraction of the included case reports was considered of high quality (7.7%) and none of the case series were of high quality. This reduced our ability to abstract all relevant data and to construct a meaningful picture of all the included articles, which resulted in some studies being classified as “other” or “unclear” in several categories.…”

Section: Strength and Limitationsmentioning

confidence: 99%

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Janoudi¹,

Uzun²,

Boyd³

et al. 2023

IJWH

View full text Add to dashboard Cite

Background Preeclampsia is a leading cause of maternal and perinatal mortality and morbidity. The management of preeclampsia has not changed much in more than two decades, and its aetiology is still not fully understood. Case reports and case series have traditionally been used to communicate new knowledge about existing conditions. Whether this is true for preeclampsia is not known. Objective To determine whether recent case reports or case series have generated new knowledge and clinical discoveries about preeclampsia. Methods A detailed search strategy was developed in consultation with a medical librarian. Two bibliographic databases were searched through Ovid: Embase and MEDLINE. We selected case reports or case series published between 2015 and 2020, comprising pregnant persons diagnosed with hypertensive disorders of pregnancy, including preeclampsia. Two reviewers independently screened all publications. One reviewer extracted data from included studies, while another conducted a quality check of extracted data. We developed a codebook to guide our data extraction and outcomes assessment. The quality of each report was determined based on Joanna Briggs Institute (JBI) critical appraisal checklist for case reports and case series. Results We included 104 case reports and three case series, together comprising 118 pregnancies. A severe presentation or complication of preeclampsia was reported in 81% of pregnancies, and 84% had a positive maternal outcome, free of death or persistent complications. Only 8% of the case reports were deemed to be of high quality, and 53.8% of moderate quality; none of the case series were of high quality. A total of 26 of the 107 publications (24.3%) included a novel clinical discovery as a central theme. Conclusion Over two-thirds of recent case reports and case series about preeclampsia do not appear to present new knowledge or discoveries about preeclampsia, and most are of low quality.

show abstract

Section: Strength and Limitationsmentioning

confidence: 99%

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Janoudi¹,

Uzun²,

Boyd³

et al. 2023

IJWH

View full text Add to dashboard Cite

show abstract

“…Destruction of the red blood cells caused by haemolysis leads to increased serum lactate dehydrogenase levels (LDH) and decreased haemoglobin concentration. Haemoglobinuria can be macroscopically recognizable (19). Liberated haemoglobin is converted to unconjugated bilirubin, which leads to its increased plasma levels, or it may be bound in the plasma by haptoglobin.…”

Section: Pathogenesis and Diagnosis Of The Hellpmentioning

confidence: 99%

Postpartum corticosteroids in HELLP syndrome – standard to prompt recovery

Gábor¹,

Drab²,

Holomán³

2016

BLL

View full text Add to dashboard Cite

OBJECTIVES: To perform a complex review of HELLP syndrome and its treatment from up to date scientifi c literature. Study of the interresting treatement regime of the patient. METHODS: Complex analysis of the syndrome, systematic search of medical scientifi c databases and Slovak Medical Library. Analysis of the life threatening state of the patient, retrospective analysis of the diagnostics, treatment, acute management, complications and clinical results. RESULTS: According to up to date literature and our good clinical experiences we can encourage the use of high-dose corticosteroid therapy in HELLP syndrome. CONCLUSION: The most recent studies defi nitely recommend the high dose corticosteroid treatment in recovery management by the HELLP syndrome. We have used the high-dose corticosteroid regime as a recovery management for the patient with postpartum HELLP with very good clinical and laboratory response followed by prompt recovery of the patient and without other complications. We want to support and empasize the indication of the Dexamethasone regiment by HELLP, becouse the clinical experiences with this treatment are not well-known and usually the corticosteroids are not given to the patients with HELLP, or the treatment is "daemonized". Our clinical experience with this treatment was successful and the patient defi nitely profi ted of it. We support the opinion, that the benefi t of described regiment highly exceedes the possible adverse effects of the therapy (Fig. 8, Ref. 61). Text in PDF www.elis.sk.

show abstract

Placental abruption as a trigger of DIC in women with HELLP syndrome: a population-based study

Gomez-Tolub

Rabinovich

Kachko

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

The importance of angiogenic markers in the differential diagnosis of HELLP syndrome vs. non-HELLP thrombocytopenia

Cited by 3 publications

References 11 publications

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Postpartum corticosteroids in HELLP syndrome – standard to prompt recovery

Placental abruption as a trigger of DIC in women with HELLP syndrome: a population-based study

Contact Info

Product

Resources

About