Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study

Abstract

These findings do not indicate a long-term detrimental effect of VKAs on cognition, but the risk-benefit balance of VKA treatment still deserves further research.

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

“…Since neurological signs are directly related to the strategic location of damage, and since executive functioning needs the integrity of the frontal-subcortical circuits [22], these neuroimaging data are consistent with those from previous neuropsychological studies which reported more severe executive disorders at baseline among older adults using VKAs, and greater executive decline during follow-up [8, 9]. Similarly, we also found focal atrophy in the precuneus, a brain region essential to a range of highly integrated tasks, including episodic memory [23], which has previously been related to vitamin K, with increased concentrations of vitamin K being associated with better memory performance [24].…”

“…In humans, clinical epidemiological studies have shown associations of the use of VKAs with cognitive disorders [5, 7] and decline of executive functions [8, 9]. Conversely, very few studies have examined the impact of the use of VKAs on brain structure.…”

Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats

“…The amount of warfarin involved in this experimental paradigm does not compare in any way to the doses used in the clinical setting where VK antagonists such as warfarin are prescribed for the prevention of thromboembolic diseases; the primary end-point of VK antagonists being to suppress the coagulation cascade ( Ansell et al, 2008 ). In recent years, our group has conducted a number of studies in elderly patients undergoing anticoagulation therapy with VK antagonists and while use of these drugs was found to be independently associated with lower cognitive function in cross-sectional analyses, results did not suggest cumulative long-term detrimental effects ( Annweiler et al, 2015 ; Ferland et al, 2016b ). Hence, whether VK antagonists alter brain function through their impact on sphingolipid metabolism or other mechanisms, or benefit cognition through their antithrombotic effects, remains a topic of current investigation.…”

Atrial fibrillation as Risk Factor for Development of Cognitive Function Impairment and Dementia. Potential of Anticoagulant Therapy in Their Prevention

“…Влияние терапии варфарином на состояние когнитивных функций пациентов с ФП изучалось в нескольких исследованиях [52,[66][67][68]. Согласно результатам исследования G. Ferland и соавт.…”

“…Согласно результатам исследования G. Ferland и соавт. [66], терапия варфарином не влияла на состояние когнитивных функций у пациентов с ФП. Сходные результаты были получены и Н. Stefansdottir и соавт.…”