HALT &amp; REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Lanters, Eva A.H.; Marion, Denise M. S. van; Kik, Charles; Steen, Herman; Bogers, Ad J.J.C.; Allessie, Maurits A.; Brundel, Bianca J. J. M.; Groot, Natasja M.S. de

doi:10.1186/s12967-015-0714-7

Cited by 40 publications

(41 citation statements)

References 31 publications

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“…From December 2014 till November 2016, 297 subjects >18 years with or without a history of AF were prospectively enrolled for the HALT & REVERSE study [ 23 ] at the department of cardiology in the Erasmus MC, Rotterdam, the Netherlands. The study population consists of a control group of patients without a history of AF and a study group of patients with symptomatic AF who were scheduled for electrical cardioversion (ECV) or pulmonary vein isolation (PVI).…”

Section: Methodsmentioning

confidence: 99%

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

Marion

Lanters

Ramos

et al. 2020

Cells

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Background: Staging of atrial fibrillation (AF) is essential to understanding disease progression and the accompanied increase in therapy failure. Blood-based heat shock protein (HSP) levels may enable staging of AF and the identification of patients with higher risk for AF recurrence after treatment. Objective: This study evaluates the relationship between serum HSP levels, presence of AF, AF stage and AF recurrence following electrocardioversion (ECV) or pulmonary vein isolation (PVI). Methods: To determine HSP27, HSP70, cardiovascular (cv)HSP and HSP60 levels, serum samples were collected from control patients without AF and patients with paroxysmal atrial fibrillation (PAF), persistent (PeAF) and longstanding persistent (LSPeAF) AF, presenting for ECV or PVI, prior to intervention and at 3-, 6- and 12-months post-PVI. Results: The study population (n = 297) consisted of 98 control and 199 AF patients admitted for ECV (n = 98) or PVI (n = 101). HSP27, HSP70, cvHSP and HSP60 serum levels did not differ between patients without or with PAF, PeAF or LSPeAF. Additionally, baseline HSP levels did not correlate with AF recurrence after ECV or PVI. However, in AF patients with AF recurrence, HSP27 levels were significantly elevated post-PVI relative to baseline, compared to patients without recurrence. Conclusions: No association was observed between baseline HSP levels and the presence of AF, AF stage or AF recurrence. However, HSP27 levels were increased in serum samples of patients with AF recurrence within one year after PVI, suggesting that HSP27 levels may predict recurrence of AF after ablative therapy.

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Section: Methodsmentioning

confidence: 99%

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

Marion

Lanters

Ramos

et al. 2020

Cells

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“…The study population consisted of 253 successive adult patients undergoing elective open heart coronary artery bypass grafting, aortic or mitral valve surgery, or a combination of valvular and bypass grafting surgery in the Erasmus Medical Center Rotterdam. This study was approved by the institutional medical ethical committee (MEC2010-054/MEC2014-393) 8,9 ; written informed consent was obtained from all patients. Preoperative ECG and clinical data were extracted from electronic patient files.…”

Section: Study Populationmentioning

confidence: 99%

1004Impact of ischemic and valvular heart disease on atrial excitation: a high-resolution epicardial mapping study

et al. 2018

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Background--The influence of underlying heart disease or presence of atrial fibrillation (AF) on atrial excitation during sinus rhythm (SR) is unknown. We investigated atrial activation patterns and total activation times of the entire atrial epicardial surface during SR in patients with ischemic and/or valvular heart disease with or without AF.Methods and Results--Intraoperative epicardial mapping (N=128/192 electrodes, interelectrode distances: 2 mm) of the right atrium, Bachmann's bundle (BB), left atrioventricular groove, and pulmonary vein area was performed during SR in 253 patients (186 male [74%], age 66AE11 years) with ischemic heart disease (N=132, 52%) or ischemic valvular heart disease (N=121, 48%). As expected, SR origin was located at the superior intercaval region of the right atrium in 232 patients (92%). BB activation occurred via 1 wavefront from right-to-left (N=163, 64%), from the central part (N=18, 7%), or via multiple wavefronts (N=72, 28%). Left atrioventricular groove activation occurred via (1) BB: N=108, 43%; (2) pulmonary vein area: N=9, 3%; or (3) BB and pulmonary vein area: N=136, 54%; depending on which route had the shortest interatrial conduction time (P<0.001). Ischemic valvular heart disease patients more often had central BB activation and left atrioventricular groove activation via pulmonary vein area compared with ischemic heart disease patients (N=16 [13%] versus N=2 [2%]; P=0.009 and N=86 [71%] versus N=59 [45%]; P<0.001, respectively). Total activation times were longer in patients with AF (AF: 136AE20 [92-186] ms; no AF: 114AE17 [74-156] ms; P<0.001), because of prolongation of right atrium (P=0.018) and BB conduction times (P<0.001).Conclusions--Atrial excitation during SR is affected by underlying heart disease and AF, resulting in alternative routes for BB and left atrioventricular groove activation and prolongation of total activation times. Knowledge of atrial excitation patterns during SR and its electropathological variations, as demonstrated in this study, is essential to further unravel the pathogenesis of AF. ( J Am Heart Assoc. 2018;7:e008331.

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“…Table 3 shows additional clinical characteristics of patients with and without LPoAF. Overall time to LPoAF diagnosis was 6 (3-6) months and was similar in patients with (N=40, 6 [3][4][5][6]) and patients without (N=4, 8 [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]) preoperative AF (P=0.708).…”

Section: Late Postoperative Afmentioning

confidence: 92%

“…Patients were included in either the QUASAR (Quest for the Arrhythmogenic Substrate of Atrial Fibrillation) or HALT&REVERSE (HSF1 activators lower cardiomyocyte damage; towards a novel approach to reverse AF) project, which were both approved by the institutional medical ethical committee (MEC2010‐054 and MEC2014‐393). All patients provided written informed consent before inclusion.…”

Section: Methodsmentioning

confidence: 99%

Intraoperative Inducibility of Atrial Fibrillation Does Not Predict Early Postoperative Atrial Fibrillation

Lanters

Teuwen

Yaksh

et al. 2018

JAHA

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BackgroundEarly postoperative atrial fibrillation (EPoAF) is associated with thromboembolic events, prolonged hospitalization, and development of late PoAF (LPoAF). It is, however, unknown if EPoAF can be predicted by intraoperative AF inducibility. The aims of this study are therefore to explore (1) the value of intraoperative inducibility of AF for development of both EPoAF and LPoAF and (2) the predictive value of de novo EPoAF for recurrence of LPoAF.Methods and ResultsPatients (N=496, 75% male) undergoing cardiothoracic surgery for coronary and/or valvular heart disease were included. AF induction was attempted by atrial pacing, before extracorporeal circulation. All patients were on continuous rhythm monitoring until discharge to detect EPoAF. During a follow‐up period of 2 years, LPoAF was detected by ECGs and Holter recordings. Sustained AF was inducible in 56% of patients. There was no difference in patients with or without AF before surgery (P=0.159), or between different types of surgery (P=0.687). In patients without a history of AF, incidence of EPoAF and LPoAF was 37% and 2%, respectively. EPoAF recurred in 58% patients with preoperative AF, 53% developed LPoAF. There were no correlations between intraoperative inducibility and EPoAF or LPoAF (P>0.05). EPoAF was not correlated with LPoAF in patients without a history of AF (P=0.116), in contrast to patients with AF before surgery (P<0.001).ConclusionsIntraoperative AF inducibility does not predict development of either EPoAF or LPoAF. In patients with AF before surgery, EPoAF is correlated with LPoAF recurrences. This correlation is absent in patients without AF before surgery.

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HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation

Cited by 40 publications

References 31 publications

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation

1004Impact of ischemic and valvular heart disease on atrial excitation: a high-resolution epicardial mapping study

Intraoperative Inducibility of Atrial Fibrillation Does Not Predict Early Postoperative Atrial Fibrillation

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