The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

Pattaro, Cristian; Gögele, Martin; Mascalzoni, Deborah; Melotti, Roberto; Schwienbacher, Christine; Grandi, Alessandro De; Foco, Luisa; D’Elia, Yuri; Linder, Barbara; Fuchsberger, Christian; Minelli, Cosetta; Egger, Clemens; Kofink, Lisa S.; Zanigni, Stefano; Schäfer, Torsten; Facheris, Maurizio; Smarason, Sigurdur; Rossini, Alessandra; Hicks, Andrew A.; Weiss, Helmuth; Pramstaller, Peter P.

doi:10.1186/s12967-015-0704-9

Cited by 78 publications

(122 citation statements)

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“…This strategy was used in the Cooperative Health Research In South Tyrol (CHRIS) study [40], a population-based study aiming to investigate the genetic and molecular basis of age-related common chronic conditions and their interaction with life-style and environment in the general population [28]. To recruit participants from rural areas to the study, village information meetings, broadcasts of information to the public through the local media and web-based recruitment were combined to maximise family participation.…”

Section: Resultsmentioning

confidence: 99%

Dynamic Consent: a potential solution to some of the challenges of modern biomedical research

et al. 2017

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BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures.

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Section: Resultsmentioning

confidence: 99%

Dynamic Consent: a potential solution to some of the challenges of modern biomedical research

et al. 2017

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“…The present study examined 4,979 participants of the population-based CHRIS study of primarily native German speakers (95%), set in an Alpine region of northern Italy. 31 The CHRIS study has been investigating the epidemiology of cardiovascular and neurological conditions typical of human ageing. All participants underwent a session at the study center that includes physical examinations, a structured clinical interview, and self-administered questionnaires.…”

Section: Study Populationmentioning

confidence: 99%

“…Participants had an age range of 18 to 93 years and gender-age distribution similar to that of the adult population living in the region, with slight underrepresentation of the elderly (aged 75 years). 31 The study was approved by the local Research Ethics Committee. All participants gave written informed consent.…”

Section: Study Populationmentioning

confidence: 99%

“…We have extended previous research by conducting an internal validation of the PSQ structure in an adult population-based sample of wide age range from the Cooperative Health Research In South Tyrol (CHRIS) study. 31 Specific objectives were 1) to explore and compare models with a variable number of factors according to both theoretical construction and previous empirical findings, 2) to identify items that may impair the factorial stability of the PSQ and address the option of excluding such items from the score, and 3) to test the questionnaire structural consistency between genders.…”

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confidence: 99%

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Structural Consistency of the Pain Sensitivity Questionnaire in the Cooperative Health Research In South Tyrol (CHRIS) Population-Based Study

Melotti

Ruscheweyh

Pramstaller

et al. 2018

The Journal of Pain

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The self-reported Pain Sensitivity Questionnaire (PSQ) is a valid supplement to experimental pain testing. However, the latent constructs determining the originally proposed 1 general score (PSQ-total) and 2 subscores (PSQ-moderate and PSQ-minor) have not been consistently investigated in population-based studies or between genders. Based on a single construct hypothesized by expert knowledge or alternative constructs upon empirical evidence, PSQ structures were explored and confirmed among 4,820 participants aged 18 to 93 years of the Cooperative Health Research In South Tyrol (CHRIS) study. By exploratory factor analysis, we identified 3 alternative sets of PSQ imagined painful situations comprising 14, 10, and 9 items, which displayed simple structures of the rotated factor loadings of direct interpretation. In confirmatory analysis (CFA) of 1 latent factor, the 10-item set yielded acceptable goodness-of-fit overall, better fit than the alternative sets and consistent structural properties between genders. Separate analyses based on 14- and 9-item sets returned considerable correlations between 2 latent constructs. In higher-order CFA with each set, 1 first-order general factor explained a large part of the variances of 2 second-order factors. One dominant construct consistently describes the factorial structure of the PSQ. Averaging across the 10-item set, the PSQ-short score represents a structurally robust, gender-consistent, and practical measure of general pain sensitivity. PERSPECTIVE: One dominant latent construct of general pain sensitivity consistently determines responses to the self-reported PSQ. The PSQ-short score maintains similar psychometric properties to the PSQ-total and between genders. This measure is attractive for large-scale research and clinical screening of pain sensitivity.

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“…We have previously demonstrated that HILIC-MS methods are suitable for separating polar metabolites [31,19]. Since we are interested in polar metabolites, in this study, we analyzed the metabolomes extracted from VAMS by using a HILIC-MS method designed for the large-scale studies of plasma and serum samples [34]. All extracting solutions, except for pH 9 solution, gave clear (uncolored) extracts.…”

Section: Europe Pmc Funders Author Manuscriptsmentioning

confidence: 99%

Pre-analytic evaluation of volumetric absorptive microsampling and integration in a mass spectrometry-based metabolomics workflow

et al. 2017

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Volumetric absorptive microsampling (VAMS) is a novel approach that allows single-drop (10 μL) blood collection. Integration of VAMS with mass spectrometry (MS)-based untargeted metabolomics is an attractive solution for both human and animal studies. However, to boost the use of VAMS in metabolomics, key pre-analytical questions need to be addressed. Therefore, in this work, we integrated VAMS in a MS-based untargeted metabolomics workflow and investigated pre-analytical strategies such as sample extraction procedures and metabolome stability at different storage conditions. We first evaluated the best extraction procedure for the polar metabolome and found that the highest number and amount of metabolites were recovered upon extraction with acetonitrile/water (70:30). In contrast, basic conditions (pH 9) resulted in divergent metabolite profiles mainly resulting from the extraction of intracellular metabolites originating from red blood cells. In addition, the prolonged storage of blood samples at room temperature caused significant changes in metabolome composition, but once the VAMS devices were stored at − 80 °C, the metabolome remained stable for up to 6 months. The time used for drying the sample did also affect the metabolome. In fact, some metabolites were rapidly degraded or accumulated in the sample during the first 48 h at room temperature, indicating that a longer drying step will significantly change the concentration in the sample. KeywordsMetabolomics; Volumetric absorptive microsampling; Mass spectrometry ✉ Giuseppe Paglia beppepaglia@gmail.com. Compliance with ethical standardsThis study was performed in accordance with the ethical standards. The local ethics committee (Comitato etico del comprensorio sanitario di Bolzano) approved the study, and all participants provided written informed consent.

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The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

Cited by 78 publications

References 75 publications

Dynamic Consent: a potential solution to some of the challenges of modern biomedical research

Dynamic Consent: a potential solution to some of the challenges of modern biomedical research

Structural Consistency of the Pain Sensitivity Questionnaire in the Cooperative Health Research In South Tyrol (CHRIS) Population-Based Study

Pre-analytic evaluation of volumetric absorptive microsampling and integration in a mass spectrometry-based metabolomics workflow

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