A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?

Grosso, Giuseppe; Marventano, Stefano; Yang, Justin; Micek, Agnieszka; Pająk, Andrzej; Scalfi, Luca; Galvano, Fabio; Kales, Stephen N.

doi:10.1080/10408398.2015.1107021

Cited by 351 publications

(211 citation statements)

References 55 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…Meta-analyses of studies on legume consumption and cardiovascular health demonstrated no association with Public Health Nutrition: 20(2), 245-254 doi:10.1017/S1368980016002299 *Corresponding author: Email stefano.marventano@studium.unict.it © The Authors 2016 stroke or diabetes (13,14) . Legumes considered as part of a Mediterranean dietary pattern have been associated with a decreased risk of CVD risk and mortality in studies evaluating Mediterranean diet as main exposure (15) , but a comprehensive evaluation of their independent role on such outcomes is lacking. The aim of the present study was to systematically review and perform a meta-analysis of prospective cohort studies exploring the association between dietary legume consumption and CVD risk, including CHD and stroke.…”

Section: Introductionmentioning

confidence: 99%

Legume consumption and CVD risk: a systematic review and meta-analysis

Marventano

Izquierdo-Pulido

Sánchez-González

et al. 2016

Public Health Nutr.

Self Cite

120

View full text Add to dashboard Cite

Objective: The aim of the present study was to systematically review and perform a meta-analysis of prospective cohort studies exploring the association between dietary legume consumption and CVD risk, including CHD and stroke. Design: The PubMed and EMBASE databases were searched up to December 2015. A meta-analysis of the highest v. lowest (reference) category of dietary legume consumption was performed through random-effects models. Results: Fourteen studies conducted on eleven cohorts and accounting for a total of 367 000 individuals and 18 475 cases of CVD (7451 CHD and 6336 stroke cases) were considered for the analyses. Compared with lower legume consumption, the highest category of exposure was associated with a decreased risk of 10 % in both CVD and CHD (relative risk = 0·90; 95 % CI 0·84, 0·97) with no or little evidence of heterogeneity and no publication bias. Null results were found regarding legume consumption and stroke risk. No substantial confounding factors were evident in stratified analyses. Conclusions: Legume consumption was associated with lower risk of CVD. Legumes' intrinsic characteristics, because they are often part of an overall healthy diet, or because they are a substitute for unhealthy sources of protein may potentially explain the current findings.Keywords CVD Fibre Legumes Meta-analysis Mortality CVD represent the main causes of death globally, accounting for nearly one-third of all deaths worldwide (1) . Moreover, as life expectancy has improved in both developed and developing countries, the number of healthy years lost due to disability has been increasing consistently (2) . Within this scenario, primary prevention of CVD-related morbidity and mortality represents a major priority for public health strategies to reduce the burden of such conditions (3) . Lifestyle factors have been considered main targets to prevent CVD, because they are modifiable behaviours that could highly affect both the risk and the prognosis of the disease. A number of healthy dietary patterns have demonstrated beneficial effects in decreasing the burden of CVD-related risk factors and CVD incidence and mortality (4,5) . Scientific literature suggests that a diet rich in antioxidants (such as vitamins and polyphenols), fibre, n-3 fatty acids, MUFA and PUFA may decrease the risk of the aforementioned conditions (6,7) . Among the potential mechanisms of protection, the antioxidant and anti-inflammatory action of these compounds may mediate their effects (8,9) . From a nutritional point of view, legumes are a source of some of these nutrients and bioactive compounds as well as an excellent source of fibre and vegetable proteins (10,11) . Despite not being associated with decreased risk of CVD themselves, vegetable proteins may be a valuable alternative to animal proteins, which on the contrary are associated with saturated fats and possible adverse outcomes (12) . Meta-analyses of studies on legume consumption and cardiovascular health demonstrated no association with Public Health Nutrition: 20(2...

show abstract

Section: Introductionmentioning

confidence: 99%

Legume consumption and CVD risk: a systematic review and meta-analysis

Marventano

Izquierdo-Pulido

Sánchez-González

et al. 2016

Public Health Nutr.

Self Cite

120

View full text Add to dashboard Cite

show abstract

“…This is supported by the low-prevalence found for some NCDs including certain types of cancers and CVDs in countries from the Mediterranean region in comparison to the other parts of the world [9,10,11,12,13,14]. A similar association of adherence to a Mediterranean Diet (MD) with cancer mortality, risk of several cancer types [15], and CVD incidence and its associated mortality have been reported [15,16]. …”

Section: Introductionmentioning

confidence: 76%

Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

Reboredo‐Rodríguez

Varela-López

Forbes-Hernández

et al. 2018

IJMS

View full text Add to dashboard Cite

Non-communicable diseases (NCDs) have become the largest contributor to worldwide morbidity and mortality. Among them, cancer and cardiovascular diseases (CVDs) are responsible for a 47% of worldwide mortality. In general, preventive approaches modifying lifestyle are more cost-effective than treatments after disease onset. In this sense, a healthy diet could help a range of NCDs, such as cancer and CVDs. Traditional Mediterranean Diet (MD) is associated by the low-prevalence of certain types of cancers and CVDs, where olive oil plays an important role. In fact, different epidemiological studies suggest that olive oil consumption prevents some cancers, as well as coronary heart diseases and stroke incidence and mortality. Historically, the beneficial health effects of virgin olive oil (VOO) intake were first attributed to the high concentration of monounsaturated fatty acids. Nowadays, many studies indicate that phenolic compounds contained in olive oil have positive effects on different biomarkers related to health. Among them, phenolic compounds would be partially responsible for health benefits. The present work aims to explore, in studies published during the last five years, the effects of the main phenolic compounds isolated from olive oil on different cancer or CVD aspects, in order to clarify which compounds have more potential to be used as nutraceuticals with preventive or even therapeutic properties.

show abstract

“…[7][8][9] Table 2 summarizes the multiple health benefits of MD and the respective types of supportive evidence. [10][11][12][13][14][15][16] …”

Section: Essential Elements and Health Benefits Of The Mediterraneanmentioning

confidence: 99%

What Is the Mediterranean Diet and How Can It Be Used to Promote Workplace Health?

2016

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

Public Health. As a result of the worldwide epidemics of obesity and diabetes, there is strong and renewed interest in the traditional Mediterranean Diet (MD). The appeal of the MD extends beyond its many proven health benefits. By combining diverse flavors, colors, and aromas fresh from the land and sea and its liberal use of olive oil, herbs, and lean proteins, the MD provides delicious meals capable of transporting us to Mediterranean locales through our senses. Moreover, because of its emphasis on limited consumption, rather than abstention from red meat and sweets, as well as permitting the moderate use of alcohol, the MD represents a healthy, yet indulgent and appealing lifestyle that can be sustained over long periods of time.

show abstract

A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?

Cited by 351 publications

References 55 publications

Legume consumption and CVD risk: a systematic review and meta-analysis

Legume consumption and CVD risk: a systematic review and meta-analysis

Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

What Is the Mediterranean Diet and How Can It Be Used to Promote Workplace Health?

Contact Info

Product

Resources

About