Altered cerebellar-amygdala connectivity in violent offenders: A resting-state fMRI study

Leutgeb, Verena; Wabnegger, Albert; Leitner, Mario; Zussner, Thomas; Scharmüller, Wilfried; Klug, Doris; Schienle, Anne

doi:10.1016/j.neulet.2015.10.063

Cited by 46 publications

(38 citation statements)

References 30 publications

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“…The rs-fMRI technology is concerned with the neuronal activity in the absence of a task and has been used to indirectly measure neuronal activity [25, 26]. As a principal method for rs-fMRI, ReHo is emerging as an interesting biomarker for measuring the means of diseases.…”

Section: Discussionmentioning

confidence: 99%

Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

Chen

2017

PLoS ONE

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ObjectiveTo reveal the brain functional changes of nicotine addicts compared with those of non-smokers and explore the objective biomarker for nicotine dependence evaluation.MethodsA total of 14 smokers and 11 non-smoking controls were recruited for this study. Resting-state functional magnetic resonance imaging and regional homogeneity (ReHo) were applied in the neural activity analysis. Two-sample t-test was performed to examine the voxel-wise difference between the smokers and the controls. Correlation analysis between the ReHo values and the Fagerstrom Test for Nicotine Dependence (FTND) scores were performed to explore the biomarkers for the clinical characteristics of smokers.ResultsThe ReHo values from the right superior frontal gyrus of the Brodmann’s area (BA) 9 to the right middle frontal gyrus and the ReHo value from the left and right precuneus (BA 23) to the left and right middle cingulum gyrus were lower in the smokers than in the non-smokers. The ReHo value in the precuneus (BA 23) was significantly and positively correlated with the FTND score of smokers.ConclusionThe ReHo values in the right superior frontal gyrus and left precuneus can be used to separate the smokers from the non-smokers. In particular, the left precuneus is a potential neuroimaging biomarker for nicotine addicts.

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Section: Discussionmentioning

confidence: 99%

Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

Chen

2017

PLoS ONE

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“…On the other hand, the BLA would convey more emotional-related information to be processed into the mPFC (Garcia et al, 1999;Senn et al, 2014), and is necessary to express fear-related behaviors such as freezing (Helmstetter and Bellgowan, 1994). Alterations of its connectivity in humans has already been suggested to underlie aggressive behaviors (Leutgeb et al, 2016).…”

Section: A Distributed Brain Network For Mood Control In Health and Dmentioning

confidence: 99%

A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction

Guirado

Pérez-Rando

Ferragud

et al. 2020

Front. Behav. Neurosci.

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The medial prefrontal cortex (mPFC) has been classically defined as the brain region responsible for higher cognitive functions, including the decision-making process. Ample information has been gathered during the last 40 years in an attempt to understand how it works. We now know extensively about the connectivity of this region and its relationship with neuromodulatory ascending projection areas, such as the dorsal raphe nucleus (DRN) or the ventral tegmental area (VTA). Both areas are well-known regulators of the reward-based decision-making process and hence likely to be involved in processes like evidence integration, impulsivity or addiction biology, but also in helping us to predict the valence of our future actions: i.e., what is "good" and what is "bad." Here we propose a hypothesis of a critical period, during which the inputs of the mPFC compete for target innervation, establishing specific prefrontal network configurations in the adult brain. We discuss how these different prefrontal configurations are linked to brain diseases such as addiction or neuropsychiatric disorders, and especially how drug abuse and other events during early life stages might lead to the formation of more vulnerable prefrontal network configurations. Finally, we show different promising pharmacological approaches that, when combined with the appropriate stimuli, will be able to re-establish these functional prefrontocortical configurations during adulthood.

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“…Notably, functional magnetic resonance imaging studies, including resting-state and task-related functional connectivity confirm cerebellar relationships between the cortical and subcortical areas involved in addiction, and specifically in craving. Concretely, co-activations and functional connections between cerebellum and cortical structures, such as dorsolateral prefrontal cortex (Habas et al, 2009;Leutgeb et al, 2016;Moulton et al, 2011;Sang et al, 2012), orbitofrontal cortex (Addis et al, 2016;Habas et al, 2009;Leutgeb et al, 2016), anterior cingulate cortex (Addis et al, 2016;Moulton et al, 2011;Sang et al, 2012;Zeng et al, 2012), insula (Addis et al, 2016;Habas et al, 2009;Moulton et al, 2011;Sang et al, 2012), and inferior frontal gyrus (Addis et , 2016;Moulton et al, 2011;Tomasi and Volkow, 2011) have been reported. Other subcortical structures such as amygdala (Leutgeb et al, 2016;Sang et al, 2012;Zeng et al, 2012), hippocampus (Onuki et al, 2015;Sang et al, 2012;Zeng et al, 2012), ventral tegmental area (Carnell et al, 2014;Etkin et al, 2009;Kline et al, 2016;Kwon et al, 2014), dorsal striatum (Moulton et al, 2011;Sang et al, 2012;Tomasi and Volkow, 2011), and ventral striatum (Cauda et al, 2011;Cservenka et al, 2014;Koehler et al, 2013) also have demonstrated to be connected to the cerebellum.…”

Section: Introductionmentioning

confidence: 99%

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

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Craving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.

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Altered cerebellar-amygdala connectivity in violent offenders: A resting-state fMRI study

Cited by 46 publications

References 30 publications

Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

Regional Homogeneity Changes in Nicotine Addicts by Resting-State fMRI

A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction

The cerebellum in drug craving

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