Effectiveness of a brief psychoeducational group intervention for relatives on the course of disease in patients after inpatient depression treatment compared with treatment as usual – study protocol of a multisite randomised controlled trial

Frank, Fabian; Wilk, Juliette; Kriston, Levente; Meister, Richard; Shimodera, Shinji; Hesse, Klaus; Bitzer, EM; Berger, Thomas; Hölzel, Lars P.

doi:10.1186/s12888-015-0633-4

Cited by 9 publications

(4 citation statements)

References 63 publications

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“…Collectively, these findings attest to the need for more rigorously designed RCTs using standardized measures that address both patient and carer outcomes over longer time periods. Indeed, it is promising that recent published protocols suggest that these gaps will begin to be addressed (e.g., Frank et al., ; Katsuki et al., ). Meta‐analyses to identify strength of treatment effects, comparative clinical trials where FPE is combined with effective individual treatments for patients (e.g., cognitive‐behavioral therapy), and a better understanding of what limits uptake of FPE for MDD will further consolidate the evidence base in future years.…”

Section: Discussionmentioning

confidence: 99%

“Family Matters”: A Systematic Review of the Evidence For Family Psychoeducation For Major Depressive Disorder

Brady

Kangas

McGill

2016

J Marital Family Therapy

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The first aim of this systematic review was to evaluate the evidence for family psychoeducation (FPE) interventions for major depressive disorder (MDD). A second aim was to compare the efficacy of different modes of delivering face-to-face FPE interventions. Ten studies (based on nine distinct samples) were identified comprising four single-family studies, four multifamily studies, one single versus multifamily comparative study, and one peer-led, mixed-diagnosis study. Seven studies measured patient functioning and six reported positive outcomes. Six studies measured carer's well-being and four reported positive outcomes. Results provide preliminary evidence that FPE leads to improved outcomes for patient functioning and family-carer's well-being for persons with depression. The implications for future development and delivery of FPE interventions for MDD are discussed.

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Section: Discussionmentioning

confidence: 99%

“Family Matters”: A Systematic Review of the Evidence For Family Psychoeducation For Major Depressive Disorder

Brady

Kangas

McGill

2016

J Marital Family Therapy

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“…Subgroup analyses, moderator and mediator analyses will be performed in a similar fashion as for the primary outcome. Furthermore, the results seen in the current trial will be compared to historical controls of face-to-face psychoeducation groups for caregivers of depressive in-patients from the multicenter SCHILD study [ 29 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

An online program with individualized vs automated support for significant others of depressed individuals – study protocol of a randomized controlled trial

Schramm

Breuninger²,

Zehender³

et al. 2022

BMC Psychiatry

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Background Due to budget restrictions in mental health care, non-professional caregivers are increasingly burdened with the emotional and practical care for their depressed relatives. However, informal family caregiving is mostly a stressful role with negative consequences on the physical and mental health of the caretakers to the extent that they have an elevated risk of experiencing psychiatric disorders themselves. While psychoeducation for relatives of depressed individuals showed positive results both in terms of the caretakers’ strain and the depressive symptoms of the affected person, there are major barriers to participate in presence in those programs. Digital programs might be a viable alternative. We found no empirically evaluated digital program available for informal caregivers of depressed patients. Methods An online program for relatives of depressed individuals has been developed including four interactive modules on 1) psychoeducation, 2) how to strengthen the relationship with the depressed person, 3) how to deal with the depressive symptoms of the patient, and 4) find the right balance between caring for the depressed person and self-care. We investigate if this self-help program is more effective when used with individualized versus automated e-mail support, and if both supported conditions are more effective than treatment-as-usual (TAU in form of written information material) in terms of the risk of mental diseases in caregivers. The primary outcome is the reduction of the caregiver’s nonspecific mental distress as measured by the change of the Kessler Psychological Distress Scale score from baseline to four weeks after randomization. Caregivers (n = 500:500:250) will be randomized to one of the three conditions. Discussion Psychological support for caregivers of individuals with mental disorders such as depression should be offered as part of integrated services. There is a huge potential to develop and implement interactive online approaches to support informal caregivers of patients with depression to function in their multiple roles and to help them to remain healthy. Trial registration DRKS, DRKS00025241. Registered 5 Mai 2021.

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“…We obtained 67 relevant articles for full-text review, and a further 50 studies were excluded for the following reasons: 2 were not RCTs, 32 did not include eligible patients, 11 did not include eligible interventions, and 5 were ongoing and did not provide any actual data. [62][63][64][65][66] Thus, out of 17 remaining records, 9 studies 27,28,30-32,67-78 met the inclusion criteria for qualitative synthesis and 5 studies [72][73][74][75][76][77][78] met the inclusion criteria for the meta-analysis (supplementary Fig. 1)…”

Section: Identified Studies For the Meta-analysismentioning

confidence: 99%

Effectiveness of family psychoeducation for major depressive disorder: systematic review and meta-analysis

Katsuki

Watanabe²,

Yamada

et al. 2022

BJPsych open

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Background Although its effect has not been verified, family therapy – such as family psychoeducation (FPE) – is a widely used intervention for treating major depressive disorder (MDD). To our knowledge, no systematic review and meta-analysis exists that examines the effect of FPE on MDD. Aims To assess evidence on the effectiveness of FPE on depressive symptoms in people with MDD. Method We searched several databases – including PubMed, MEDLINE and Web of Science, among others – to identify eligible studies on the topic published up to March 2022. Our criteria included studies on participants with a primary MDD diagnosis and their family members and excluded studies on people with bipolar disorders and other mental illnesses. In the included studies, family members in the control groups did not receive FPE. Participants in both the intervention and control groups received standard treatment. Two researchers independently selected relevant publications, extracted data and evaluated methodological quality using the Cochrane risk of bias assessment tool and GRADE evaluation. The protocol was registered with PROSPERO (no. CRD42020185884). Results The meta-analysis included five studies with 301 patients with MDD and their family members. The effect of FPE on patients’ symptom severity, compared with the control condition, at 16 weeks was available for five comparisons of four randomised control trials (RCTs); a final follow-up was available for six comparisons of five RCTs. The meta-analysis showed a statistically significant improvement in patients’ symptoms, compared with control, at 16 weeks (s.m.d. = −0.52, 95% CI −1.03 to −0.01) and at a final follow-up (s.m.d. = −0.53, 95% CI −0.98 to −0.08). The meta-analysis on the effect of FPE on family functioning showed a non-significant improvement both at 16 weeks and at final follow-up. Conclusions FPE had a small but statistically significant effect on depressive symptoms in people with MDD, in both the short and long term. However, according to the GRADE framework, all outcomes are graded very low on certainty; therefore, more high-quality research is needed.

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Effectiveness of a brief psychoeducational group intervention for relatives on the course of disease in patients after inpatient depression treatment compared with treatment as usual – study protocol of a multisite randomised controlled trial

Cited by 9 publications

References 63 publications

“Family Matters”: A Systematic Review of the Evidence For Family Psychoeducation For Major Depressive Disorder

“Family Matters”: A Systematic Review of the Evidence For Family Psychoeducation For Major Depressive Disorder

An online program with individualized vs automated support for significant others of depressed individuals – study protocol of a randomized controlled trial

Effectiveness of family psychoeducation for major depressive disorder: systematic review and meta-analysis

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