Erythrocytes as Volume Markers in Experimental PD Show that Albumin Transport in the Extracellular Space Depends on PD Fluid Osmolarity

Abstract

Labeled erythrocytes are acceptable markers of intraperitoneal volume and, combined with labeled albumin, provided novel kinetic data on albumin transport in peritoneal tissues.

TRPA1 Mechanoreceptors Mediate the IL-6 Response to a Single PD Dwell in the Rat

“…Since chemical activation is unlikely, the remaining possibility is mechanic/osmotic stimulation. Peritoneal dialysis fluid exposure involves both osmotic stimulation of cells and swelling of the extracellular space due to the hydrostatic pressure increase (41). Any of these mechanisms could lead to the transmission of mechanical forces to the TRPA1 cell membrane receptors.…”