Erratum: RTN1 mediates progression of kidney disease by inducing ER stress

Fan, Ying; Xiao, Wu; Li, Zhengzhe; Li, Xuezhu; Chuang, Peter Y.; Jim, Belinda; Zhang, Weijia; Wei, Chengguo; Wang, Niansong; Wang, Jia; Xiong, Huabao; Lee, Kyung Hwa; He, John Cijiang

doi:10.1038/ncomms9710

Cited by 2 publications

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“…Looking for a solution, due to limited mechanism-based therapies targeting kidney diseases/aging, modulation of ER stress using pharmacological regimes could be a promising option/approach [ 121 , 127 ]. Apart from this, knockdown of ER stress-expressing proteins, for instance, reticulon 1 (RTN1), could contribute to halting the stress along with minimizing kidney risks [ 128 ]. Moreover, resveratrol, as a natural treatment, demonstrated a beneficial effect in alleviating ER stress and thereby improving kidney function and tubular cell injury [ 35 ].…”

Section: Pharmacological Effects Of Resveratrol On Aging Biomarkers In the Kidneymentioning

confidence: 99%

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Uddin

Farjana²,

Moni³

et al. 2021

IJMS

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Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific community and pharmaceutical companies. A literature search was carried out to collect published research information on the effects of resveratrol on kidney aging. Recently, resveratrol has emerged as a potential anti-aging agent. This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-κB. Researchers are trying to figure out the detailed mechanisms and possible resveratrol-mediated interventions in divergent pathways at the molecular level. This review highlights (i) the causative factors implicated in kidney aging and the therapeutic aspects of resveratrol, and (ii) the effectiveness of resveratrol in delaying the aging process of the kidney while minimizing all possible side effects.

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Section: Pharmacological Effects Of Resveratrol On Aging Biomarkers In the Kidneymentioning

confidence: 99%

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Uddin

Farjana²,

Moni³

et al. 2021

IJMS

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Sitagliptin ameliorates ER stress in diabetic kidney disease through upregulation of SIRT1

Zhang

Jia

et al. 2021

Diabetic Nephropathy

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Objectives Endoplasmic reticulum (ER) stress plays a significant role in the progression of diabetic kidney disease (DKD), and dipeptidyl peptidase-4 (DPP4) inhibitors are widely used antihyperglycemic agents, exerting renal beneficial effects in DKD. Here, we investigated the role of DPP4 inhibitor Sitagliptin (Sita) in ER homeostasis in the kidneys of diabetic DBA2/J (D2) mice and in albumin-stimulated HK-2 cells. Methods and Results ER stress was observed both in vivo and in vitro, as reflected by notably increased glucose-regulated protein of 78 kDa (GRP78), CHOP, high phosphorylation of PERK (p-PERK), and cleaved caspase3 (c-CASP3), whereas Sita effectively attenuated these disorders. Meanwhile, Sita increased the expression of SIRT1 both in vivo and in vitro. To further validate the potential effects of SIRT1 in regulating ER stress, we regulated SIRT1 by siRNA and overexpressed plasmids in albumin-overloaded HK-2 cells. Elevated SIRT1 alleviated albumin-induced ER stress, while decreased SIRT1 further aggravated ER stress in albumin-treated HK-2 cells. Conclusion The results suggest that a novel mechanism links the DPP4 enzyme to ER stress during tubular injury in DKD and highlight that SIRT1 may be a potential target for managing DKD.

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Erratum: RTN1 mediates progression of kidney disease by inducing ER stress

Cited by 2 publications

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Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Sitagliptin ameliorates ER stress in diabetic kidney disease through upregulation of SIRT1

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