Biocorrosion behavior of biodegradable nanocomposite fibers coated layer-by-layer on AM50 magnesium implant

Abdal‐hay, Abdalla; Hasan, Anwarul; Yu-Kyoung,; Lee, Minho; Hamdy, Abdel Salam; Khalil, Khalil Abdelrazek

doi:10.1016/j.msec.2015.09.065

Cited by 46 publications

(23 citation statements)

References 42 publications

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“…Consequently, E corr cannot be used to evaluate and validate the corrosion performance [36]. The electrochemical parameters including corrosion potential and corrosion current density (i corr ) derived from Fig.…”

Section: Corrosion Resistance Testmentioning

confidence: 99%

Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Dong

Tan

et al. 2016

Materials Science and Engineering: C

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Section: Corrosion Resistance Testmentioning

confidence: 99%

Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Dong

Tan

et al. 2016

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

“…In this regard, several issues (especially controlling the corrosion rate and improving antibacterial performance) must be considered before using Mg‐based materials for surgical implants . Improved corrosion resistance of Mg‐based materials is possible by various modifications, such as polymer coating, alloying, and other surface treatments . However, Zheng et al report that Mg alloying with other elements has an adverse effect on cell biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…To address this issue, polymer coating on Mg alloys has received considerable attention due to the ability of this method to enhance corrosion resistance and improve the biocompatibility of Mg substrates . Various natural and synthetic polymers have been studied for coating Mg alloys .…”

Section: Introductionmentioning

confidence: 99%

“…Magnesium (Mg) and its alloys have great potential for use in biodegradable implants for orthopedic applications due to their biodegradability and suitable mechanical properties similar to cortical bone. 1,2 However, poor antibacterial activity, a high rate of corrosion, and the significant release of hydrogen gas during the degradation of Mg alloys hinder biomedical applications. 3,4 In this regard, several issues (especially controlling the corrosion rate and improving antibacterial performance) must be considered before using Mg-based materials for surgical implants.…”

mentioning

confidence: 99%

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Improved antibacterial properties of an Mg‐Zn‐Ca alloy coated with chitosan nanofibers incorporating silver sulfadiazine multiwall carbon nanotubes for bone implants

Bakhsheshi‐Rad

Chen

Ismail

et al. 2019

Polymers for Advanced Techs

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Bacteria‐caused infection remains an issue in the treatment of bone defects by means of Mg‐Zn‐Ca alloy implants. This study aimed to improve the antibacterial properties of an Mg‐Zn‐Ca alloy by coating with chitosan‐based nanofibers with incorporated silver sulfadiazine (AgSD) and multiwall carbon nanotubes (MWCNTs). AgSD and MWCNTs were prepared at a weight ratio of 1:1 and then added to chitosan at varying concentrations (ie, 0, 0.25, 0.5, and 1.5 wt.%) to form composites. The obtained composites were ejected in nanofiber form using an electrospinning technique and coated on the surface of an Mg‐Zn‐Ca alloy to improve its antibacterial properties. A microstructural examination by scanning electron microscopy (SEM) revealed the diameter of chitosan nanofiber ejected increased with the concentration of AgSD‐MWCNTs. The incorporation of AgSD‐MWCNTs into the chitosan nanofibers was confirmed by Fourier transform infrared spectroscopy (FTIR). Examination of the antibacterial activity shows that chitosan nanofibers with AgSD‐MWCNTs can significantly inhibit the growth and infiltration of Escherichia coli and Staphylococcus aureus. Biocompatibility assay and cell morphology observations demonstrate that AgSD‐MWCNTs incorporated into nanofibers are cytocompatible. Taken together, the results of this study demonstrate the potential application of electrospun chitosan with AgSD‐MWCNTs as an antibacterial coating on Mg‐Zn‐Ca alloy implants for bone treatment.

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A biodegradable, mechanically tunable micro‐arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating promotes long‐term bone tissue regeneration

Liu

Yang

Zhang

et al. 2021

Biotechnology Journal

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Background To reduce the biodegradable rate and develop the long‐term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating (CaP‐CS/MAO/AZ91D) and investigated its mechanical property and long‐term bone tissue regeneration ability. Main Methods and Major Results The results showed that the binding force and bioactivity of CaP‐CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm−2. Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days. CaP‐CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers. Conclusions and Implications CaP‐CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β‐catenin pathway activation, which would allow sufficient time for bone healing. Collectively, our findings suggest that the CaP‐CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long‐term biocompatibility but also promote osteogenic mineralization.

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Biocorrosion behavior of biodegradable nanocomposite fibers coated layer-by-layer on AM50 magnesium implant

Cited by 46 publications

References 42 publications

Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Improved antibacterial properties of an Mg‐Zn‐Ca alloy coated with chitosan nanofibers incorporating silver sulfadiazine multiwall carbon nanotubes for bone implants

A biodegradable, mechanically tunable micro‐arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating promotes long‐term bone tissue regeneration

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