Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking

Ghosh, Smita; Cabral, Jaydee; Hanton, Lyall R.; Moratti, Stephen C.

doi:10.1016/j.actbio.2015.10.018

Cited by 31 publications

(25 citation statements)

References 59 publications

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“…Oxime-based hydrogels can be formed using aminooxy-functionalized polymers and aldehyde-functionalized polymers. Aminooxy-functionalized polymers can be synthesized in two steps using the Mitsunobu reaction, coupling N -hydroxyphthalimide with hydroxyl on the polymers, followed by deprotection with hydrazine (Figure 5) [8,47,60,61,62,63,64]. Grover et al reported on oxime-based injectable hydrogels using aminooxy-functionalized four-arm poly(ethylene oxide) (AO-PEO) and ketone-functionalized four-arm poly(ethylene oxide) (Ket-PEO) [60].…”

Section: Design and Preparationmentioning

confidence: 99%

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

2019

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Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors.

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Section: Design and Preparationmentioning

confidence: 99%

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

2019

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“…Smita Ghosh et al added oxime into PEO solution to create PEO hydrogels with excellent adhesive and non-cytotoxic properties. 40 Moreover, Jurkin et al studied the factors inuencing the crosslinking of PEO powders under irradiation via different measurement techniques. 41 For maintaining the basic morphology of electrospun PEO bers, some researchers prepared UV-initiated crosslinked electrospun PEO nanobers by adding a crosslinking agent into precursor solutions.…”

Section: Introductionmentioning

confidence: 99%

The photocatalytic degradation of chloramphenicol with electrospun Bi₂O₂CO₃-poly(ethylene oxide) nanofibers: the synthesis of crosslinked polymer, degradation kinetics, mechanism and cytotoxicity

Song

et al. 2019

RSC Adv.

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“…The hydrogel formation time ranged from a couple of seconds to less than one minute by varying the concentration of the components [59]. Similarly, aldehyde and oxyamine functionalized PEG was cross-linked through Schiff-base chemistry [60]. The hydrazone linkage is known to be labile and reversible due to hydrolysis, which may cause instability to hydrogels.…”

Section: Schiff-base Reactionmentioning

confidence: 99%

In Situ‐Forming Cross‐linking Hydrogel Systems: Chemistry and Biomedical Applications

Bi¹,

Liang²

2016

Emerging Concepts in Analysis and Applications of Hydrogels

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With the development of chemical synthetic strategies and available building blocks, in situ-forming hydrogels have attracted significant attention in the biomedical fields over the past decade. Due to their distinct properties of easy management and minimal invasiveness via simple aqueous injections at target sites, in situ-forming hydrogels have found a broad spectrum of biomedical applications including tissue engineering, drug delivery, gene delivery, 3D bioprinting, wound healing, antimicrobial research, and cancer research. The objective of this chapter is to provide a comprehensive review of updated research methods in chemical synthesis of in situ-forming cross-linking hydrogel systems and their diverse applications in the biomedical fields. This chapter concludes with perspectives on the future development of in situ-forming hydrogels to facilitate this multidisciplinary field.

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Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking

Cited by 31 publications

References 59 publications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

The photocatalytic degradation of chloramphenicol with electrospun Bi₂O₂CO₃-poly(ethylene oxide) nanofibers: the synthesis of crosslinked polymer, degradation kinetics, mechanism and cytotoxicity

In Situ‐Forming Cross‐linking Hydrogel Systems: Chemistry and Biomedical Applications

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Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking

Cited by 31 publications

References 59 publications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

The photocatalytic degradation of chloramphenicol with electrospun Bi2O2CO3-poly(ethylene oxide) nanofibers: the synthesis of crosslinked polymer, degradation kinetics, mechanism and cytotoxicity

In Situ‐Forming Cross‐linking Hydrogel Systems: Chemistry and Biomedical Applications

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The photocatalytic degradation of chloramphenicol with electrospun Bi₂O₂CO₃-poly(ethylene oxide) nanofibers: the synthesis of crosslinked polymer, degradation kinetics, mechanism and cytotoxicity