T 1 correlates age: A short-TE MR relaxometry study in vivo on human cortical bone free water at 1.5 T

Akbari, Atena; Abbasi-Rad, Shahrokh; Rad, Hamidreza Saligheh

doi:10.1016/j.bone.2015.10.006

Cited by 17 publications

(29 citation statements)

References 34 publications

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“…The mean T1 free , T1 bound , r free , and r bound values among the 40 healthy women in our study were 306.79 msec, 162.47 msec, 5.89%, and 19.59%, respectively. All values were consistent with those reported in the literature (10,(29)(30)(31) (this consistency will be elaborated on in the Discussion).…”

Section: Resultssupporting

confidence: 91%

“…Bulk water measurement conflates the bound and free water information and cannot help predict the age-related alterations of the cortical bone structure, whereas differentiation between these water pools with use of our proposed method as described in Materials and Methods reveals a strong correlation between age and cortical bone free water parameters and improves the precision of the prediction conspicuously. The same results were obtained with a different method in our previous work (30).…”

Section: Solving the Optimization Problemsupporting

confidence: 83%

“…McCalden et al (34) conducted a study of 200 specimens of human cortical bone of the femur and found that an age-related increase in porosity accounted for 70% of the reduction in strength. Therefore, the success of the proposed method in the quantification of cortical bone free water will facilitate further investigations into cortical bone porosity (30,35). Before this work, several studies have been performed with the same purpose as described in the following.…”

Section: Discussionmentioning

confidence: 99%

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Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Abbasi-Rad¹,

Rad²

2017

Radiology

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Purpose To quantify free and bound water components of cortical bone with a model-based numeric approach with use of ultrashort echo time (UTE) magnetic resonance (MR) imaging in vivo in order to introduce a new predictor for age-related deterioration of cortical bone structure. Materials and Methods Human studies were compliant with HIPAA and approved by the institutional review board. Dual-repetition time three-dimensional hybrid-radial UTE imaging was performed, followed by the application of postprocessing algorithms, to quantify free and bound water parameters (concentration [ρ] and longitudinal relaxation time [T1]) of human cortical bone in vivo. The postprocessing algorithms included the decomposition of bulk equations into free- and bound-associated equations and solving resulted inverse problem by using evolutionary strategy methods. To test the validity of the introduced biomarker, it was measured in 40 healthy women by using the proposed method, and associations among parameters were evaluated with the Pearson correlation coefficient. Results The mean free water concentration, bound water concentration, free water T1, and bound water T1 in the recruited population were 5.9%, 19.6%, 306.79 msec, and 162.47 msec, respectively. All reported values were in good agreement with those in the literature. Cortical bone free water T1 (R = 0.72) and cortical bone free water concentration (R = 0.62) showed strong positive correlations with age. Conclusion The cortical bone free water concentration and free water T1 derived with UTE imaging are good predictors of age-related deterioration of cortical bone structure and are potentially superior to previously introduced measures such as bone water concentration and suppression ratio. RSNA, 2017.

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Section: Resultssupporting

confidence: 91%

Section: Solving the Optimization Problemsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Abbasi-Rad¹,

Rad²

2017

Radiology

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“…More recently, Akbari et al proposed the use of a clinical gradient echo sequence with a relatively short echo time of ∼1.29 ms and variable TRs (ie, TR = 20 and 60 ms) to measure the T 1 of pore water. They reported a relatively short T 1 of 111–243 ms for the T 1 of pore water at 1.5 T . The

{normalT}_{1}^{BW}

value from our study is very close to that reported by Seifert et al Meanwhile, the mean

{normalT}_{1}^{PW}

values of 880 ± 281 ms at 3 T and 1790 ± 470 ms at 7 T from the Seifert study are significantly higher than the mean

{normalT}_{1}^{PW}

values of 545 ± 28 ms at 3 T from our study, 551 ± 120 ms at 4.7 T from the Horch study, and 111–243 ms at 1.5 T from the Akbari study.…”

Section: Discussionsupporting

confidence: 89%

“…As a result, T PW 1 can be measured selectively with UTE-VTR acquisitions with a longer TE (eg, 2.5 ms). Pore water T 1 can then be measured with the following equation [34]:…”

Section: Measurement With Ute Variable Tr (Ute-vtr) Approachmentioning

confidence: 99%

Measurement of bound and pore water T₁relaxation times in cortical bone using three-dimensional ultrashort echo time cones sequences

Chang

Carl²,

et al. 2016

Magn. Reson. Med.

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Purpose We present three dimensional ultrashort echo time Cones (3D UTE Cones) techniques for quantification of total water T1s (T1TW), bound water T1s (T1BW) and pore water T1s (T1PW) in vitro and in vivo using a 3T scanner. Methods T1TW, T1BW and T1PW were measured with 3D Cones and adiabatic inversion recovery Cones (IR-Cones) sequences. 2D non-selective UTE techniques, including saturation recovery, variable TRs, and IR preparation approaches were compared with 3D-Cones techniques on bovine cortical bone samples (n=8). The 3D Cones sequences were used to measure T1TW, T1BW and T1PW in the tibial midshaft of healthy volunteers (n=8). Results Comparable T1s were achieved for cortical bone between 3D Cones and 2D UTE techniques as well as those published in the literature. The 3D Cones sequences showed a mean T1TW of 208±22 ms, a mean T1PW of 545±28 ms and a mean T1BW of 131±12 ms for bovine cortical bone, and a mean T1TW of 246±32 ms, a mean T1PW of 524±46 ms and a mean T1BW of 134±11 ms for the tibial midshaft of healthy volunteers. Conclusions The 3D Cones sequences can be used for fast volumetric assessment of bound and pore water T1s in vitro and in vivo.

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Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

Talebi

Abbasi-Rad

Malekzadeh

et al. 2021

Magnetic Resonance Imaging

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Background: Investigation of cortical bone using magnetic resonance imaging is a developing field, which uses short/ultrashort echo time (TE) pulse sequences to quantify bone water content and to obtain indirect information about bone microstructure. Purpose: To improve the accuracy of the previously proposed technique of free water T 1 quantification and to seek the relationship between cortical bone free water T 1 and its mechanical competence. Study Type: Prospective. Subjects: Twenty samples of bovine tibia bone. Field Strength/Sequences: 3.0 T; ultra-fast two-dimensional gradient echo, Radio frequency-spoiled three-dimensional gradient echo. Assessment: Cortical bone free water T 1 was quantified via three different methods: inversion recovery (IR), variable flip angle (VFA), and variable repetition time (VTR). Signal-to-noise ratio was measured by dividing the signal of each segmented sample to background noise. Segmentation was done manually. The effect of noise on T 1 quantification was evaluated. Then, the samples were subjected to mechanical compression test to measure the toughness, yield stress, ultimate stress, and Young modulus. Statistical Tests: All the statistical analysis (Shapiro-Wilk, way analysis of variance, paired t test, Pearson correlation, and Bland-Altman plot) were done using SPSS. Results: Significant difference was found between T 1 quantification groups (P < 0.05). Average T 1 of each quantification method differed significantly after adding noise (P < 0.05). VFA-T 1 values significantly correlated with toughness (r = À0.68, P < 0.05), ultimate stress (r = À0.71, P < 0.05), and yield stress (r = À0.62, P < 0.05). No significant correlation was found between VTR-T 1 values and toughness (P = 0.07), ultimate stress (P = 0.47), yield stress (P = 0.30), and Young modulus (P = 0.39). Data Conclusion: Pore water T 1 value is associated with bone mechanical competence, and VFA method employing short-TE pulse sequence seems a superior technique to VTR method for this quantification. Level of Evidence: 2 Technical Efficacy: 1

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T 1 correlates age: A short-TE MR relaxometry study in vivo on human cortical bone free water at 1.5 T

Cited by 17 publications

References 34 publications

Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Measurement of bound and pore water T₁relaxation times in cortical bone using three-dimensional ultrashort echo time cones sequences

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

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T 1 correlates age: A short-TE MR relaxometry study in vivo on human cortical bone free water at 1.5 T

Cited by 17 publications

References 34 publications

Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach

Measurement of bound and pore water T1relaxation times in cortical bone using three-dimensional ultrashort echo time cones sequences

Cortical Bone Mechanical Assessment via Free Water Relaxometry at 3 T

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Measurement of bound and pore water T₁relaxation times in cortical bone using three-dimensional ultrashort echo time cones sequences