Polymeric nanostructures with pH-labile core for controlled drug release

Banerjee, Rakesh; Maiti, Saikat; Dey, Debabrata; Dhara, Dibakar

doi:10.1016/j.jcis.2015.09.068

Cited by 14 publications

(3 citation statements)

References 35 publications

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“…The reduction-sensitive nanoassemblies are susceptible to cleavage under a reductive environment involving thiol–disulfide exchange reactions as compared with their reduction-insensitive counterparts. , Additionally, non-cross-linked polymeric micellar nanostructures have a major disadvantage owing to their tendency to disassemble on dilution below a certain concentration, resulting in instability and uncontrolled drug release when injected into the body. , Therefore, design and implementation of versatile strategies where the micellar cores can undergo cross-linking without the involvement of any external cross-linker should enable selective tailoring of the nanomaterials for a number of applications in various fields related to delivery of drugs and other biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Maiti

Parida

Kayal

et al. 2018

ACS Appl. Mater. Interfaces

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Success of chemotherapy as a treatment for cancer has been often inhibited by multidrug resistance (MDR) of the cancer cells. There is a clear need to generate strategies to overcome this resistance. In this work, we have developed redox-responsive and core-cross-linked micellar nanocarriers using poly(ethylene glycol)-block-poly(2-(methacryloyloxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate) diblock copolymers (PEG-b-PLAHEMA) with tunable swelling properties for the delivery of drugs toward drug-sensitive MDA-MB-231 and drug-resistant MDA-MB-231 (231R) cancer cells. PEG-b-PLAHEMA containing varying number of 2-(methacryloyloxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate (LAHEMA) units were synthesized by employing the reversible addition-fragmentation chain transfer polymerization technique. The block copolymer self-assembly, cross-linking induced by reduction, and de-cross-linking triggered time-dependent controlled swelling of micelles were studied using dynamic light scattering, fluorescence spectroscopy, and transmission electron microscopy. In vitro cytotoxicity, cellular uptake efficiency, and glutathione-responsive anticancer activity of doxorubicin (DOX) encapsulated in core-cross-linked block copolymer micelles (CCMs) toward both drug-sensitive and drug-resistant cancer cell lines were evaluated. Significant reduction in IC was observed by DOX-loaded CCMs toward drug-resistant 231R cancer cell lines, which was further improved by coencapsulating DOX and verapamil (a P-glycoprotein inhibitor) in CCMs. Thus, these reduction-sensitive biocompatible CCMs with tunable swelling property are very promising in overcoming MDR in cancer cells.

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Section: Introductionmentioning

confidence: 99%

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Maiti

Parida

Kayal

et al. 2018

ACS Appl. Mater. Interfaces

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“…To enhance efficiency of existing medication and to develop new therapeutic options for currently untreatable medical conditions, pharmaceutical research focuses not only on the screening of new active pharmaceutical ingredients (APIs) but also on the exploration of different administration routes and alternative dosage forms. Polymers can assume various crucial functions in drug formulations, providing protection against premature release 1 , 2 , stabilizing specific solid state forms 3 , 4 , enabling site-specific drug activity 5 , 6 or being functionalized themselves by anchoring drugs or proteins directly to their structure ( polymer therapeutics ) 7 . The drug release from such polymer systems is usually facilitated by either degradation/erosion of the polymer host or by diffusion of the drug; for the latter mechanism, matrix-, reservoir- and hydrogel-based systems are usually differentiated 8 .…”

Section: Introductionmentioning

confidence: 99%

Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

Christian

Tumphart

Ehmann

et al. 2018

Sci Rep

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Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.

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“…As can be seen in Figure 4i, it occurs by attaching various agents as side groups to the polymer chain and breaking the bonds at the appropriate pH value [57][58][59][60]. In addition, as shown in Figure 4j, the destruction of the polymeric network structure or the destruction of the cross-linked micelle structure can be achieved by breaking down the groups designed as cross-linkers in a pH-responsive manner [61][62][63][64][65].…”

Section: Ph-responsive Polymersmentioning

confidence: 99%

Stimuli-Responsive Polymers Providing New Opportunities for Various Applications

Koçak

Tuncer

Bütün

2020

Hacettepe Journal of Biology and Chemistry

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U yaranlara duyarlı polimerler, çevrelerindeki koşullarda küçük bir değişiklik olduğunda fiziksel veya kimyasal özelliklerini önemli ölçüde değiştirir. Koşullardaki değişikliklere bağlı olarak, bu tür kopolimerler kendiliğinden bir araya gelebilir ve çeşitli nanoboyutlu yapılar oluşturabilir. Bu tür polimerlerin farklı alanlarda önemli kullanımları vardır. Bu derlemede, çevreye duyarlı farklı polimerlerin mimarileri, duyarlılıklarına göre sınıflandırmaları ve çeşitli alanlardaki uygulamaları gibi temel konulardaki bazı güncel literatür raporlarının bir analizini sunuyoruz. Son yirmi yılda, biyoteknoloji, nanoteknoloji, kolloid ve yüzey bilimi, malzeme bilimi vb. dahil olmak üzere çeşitli uygulamalar için uygun uyarıcıya duyarlı yeni polimerlerin ve polimerik malzemelerin hazırlanmasına yönelik sentetik yöntemlerde ve stratejilerde büyük gelişmeler olmuştur. Çok geniş kapsamı olan bu polimer türünün okuyucular tarafından daha anlaşılır olabilmesi için genellikle temel kavramlar/konular şematize edilmiştir. Ayrıca, bu malzemelerin üretiminde izlenebilecek stratejiler yeter düzeyde verilmeye çalışılmıştır. Anahtar KelimelerUyarıya-duyarlı polimerler, kendi-kendine-düzenlenme, nanoyapılar, akıllı polimerler.

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Polymeric nanostructures with pH-labile core for controlled drug release

Cited by 14 publications

References 35 publications

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

Stimuli-Responsive Polymers Providing New Opportunities for Various Applications

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