Role of miR-124 and miR-141 in the regulation of vascular reactivity and the relationship to RhoA and Rac1 after hemorrhage and hypoxia

Liu, Liangming; Zang, Jiatao; Chen, Xiangyun; Yang, Guangming; Zhu, Yu; Wu, Yuzhang; Li, Tao

doi:10.1152/ajpheart.00651.2014

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…This might be the first study demonstrating the role of GAS5‐miR‐124‐ICAM‐1 axis in aggravating hypoxia injury. miR‐124 has been showed to participate in the modulation of vascular reactivity via altering expression of RhoA and Rac1 proteins, after hypoxia and hemorrhage . miR‐124 also plays a neuroprotective role in cerebral ischemic stroke through apoptosis‐inhibiting pathway, which is consistent with our data that miR‐124 overexpression dramatically impaired the apoptosis‐promoting effect of GAS5.…”

Section: Discussionsupporting

confidence: 90%

Retracted: Long non‐coding RNA GAS5 aggravates hypoxia injury in PC‐12 cells via down‐regulating miR‐124

Liu

Zhao

et al. 2018

J of Cellular Biochemistry

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One important feature of cerebral ischemia is hypoxia injury in nerve cells. Growth arrest-specific transcript 5 (GAS5) is widely reported as a tumor suppressor gene; however, the investigations about its role in cerebrovascular disease are relatively rare. This study was aimed to explore the impact of GAS5 on hypoxia response in nervous cells. PC-12 cells were incubated under anoxic condition to induce hypoxia injury. Regulatory effects of GAS5 on miR-124 and miR-124 on ICAM-1 expression were assessed by qRT-PCR and/or Western blot. Targeting effect of miR-124 on ICAM-1 3'-untranslated regions (UTR) was evaluated through dual luciferase activity assay. The potential regulatory mechanism on hypoxia injury in PC-12 cells was assessed by detecting key elements of NF-κB and Notch signaling pathways using Western blot. GAS5 ectopic expression accentuated hypoxia injury in PC-12 cells. miR-124 expression was negatively regulated by GAS5 expression. Cells with overexpressions of GAS5 and miR-124 alleviated hypoxia injury as in compassion with cells only with GAS5 overexpression. ICAM-1 expression was negatively regulated by miR-124 expression. ICAM-1 was a functional target of miR-124. ICAM-1 overexpression aggravated hypoxia injury, but inversely, ICAM-1 silence diminished hypoxia damage. Besides, ICAM-1 expression was negatively related with activation of NF-κB and Notch pathways. GAS5-miR-124-ICAM-1 axis could regulate hypoxia injury in PC-12 cells. GAS5 might aggravate hypoxia injury via down-regulating miR-124, then up-regulating ICAM-1, and further enhancing activations of NF-κB and Notch pathways.

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Section: Discussionsupporting

confidence: 90%

Retracted: Long non‐coding RNA GAS5 aggravates hypoxia injury in PC‐12 cells via down‐regulating miR‐124

Liu

Zhao

et al. 2018

J of Cellular Biochemistry

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“…Indeed, in peripheral tissues and several cancer cell lines, several studies report direct targeting of EGR1 by miR-543 (Zhu et al, 2016), miR-192 (Wu et al, 2016), miR-146a (Contreras et al, 2015), miR-7578 (Zhang et al, 2013), miR-183 (Sarver et al, 2010), or miR-124 (Liu et al, 2016; Wang et al, 2016). Interestingly, the latter is highly expressed in the brain and is a critical regulator of neuronal function and thus an important mediator of neuroadaptations in response to chronic stress, reward and learning and memory (Sun et al, 2015).…”

Section: Functions and Regulations Of Egr1mentioning

confidence: 99%

“…Furthermore, a recent investigation of miRNA directly regulated by EGR1 in the human erythroleukemia cell line K562 reported a total of 124 distinct miRNA and 63 pre-miRNA bound by EGR1 following stimulation by phorbol ester—which activates EGR1 expression in this cell line (Wang et al, 2010). One of these miRNA, miR-124, is of particular interest as it is a known regulator of EGR1 levels (Liu et al, 2016; Wang et al, 2016), including in the central nervous system (Yang et al, 2012), and is tightly associated with neuronal function and higher order processes (Sun et al, 2015). Therefore, in addition to represent a likely mediator in EGR1 control of neuronal activity, these observations suggest that miR-124 could be involved in a negative feedback loop controlling EGR1 expression at the post-transcriptional level.…”

Section: Functions and Regulations Of Egr1mentioning

confidence: 99%

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Duclot

Kabbaj

2017

Front. Behav. Neurosci.

265

240

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It is now clearly established that complex interactions between genes and environment are involved in multiple aspects of neuropsychiatric disorders, from determining an individual’s vulnerability to onset, to influencing its response to therapeutic intervention. In this perspective, it appears crucial to better understand how the organism reacts to environmental stimuli and provide a coordinated and adapted response. In the central nervous system, neuronal plasticity and neurotransmission are among the major processes integrating such complex interactions between genes and environmental stimuli. In particular, immediate early genes (IEGs) are critical components of these interactions as they provide the molecular framework for a rapid and dynamic response to neuronal activity while opening the possibility for a lasting and sustained adaptation through regulation of the expression of a wide range of genes. As a result, IEGs have been tightly associated with neuronal activity as well as a variety of higher order processes within the central nervous system such as learning, memory and sensitivity to reward. The immediate early gene and transcription factor early growth response 1 (EGR1) has thus been revealed as a major mediator and regulator of synaptic plasticity and neuronal activity in both physiological and pathological conditions. In this review article, we will focus on the role of EGR1 in the central nervous system. First, we will summarize the different factors influencing its activity. Then, we will analyze the amount of data, including genome-wide, that has emerged in the recent years describing the wide variety of genes, pathways and biological functions regulated directly or indirectly by EGR1. We will thus be able to gain better insights into the mechanisms underlying EGR1’s functions in physiological neuronal activity. Finally, we will discuss and illustrate the role of EGR1 in pathological states with a particular interest in cognitive functions and neuropsychiatric disorders.

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“… Coskunpinar et al (2016) reported an elevated level of circulating miR-221-3p in early AMI and found its significant correlation with troponin and LV systolic function. miR-124 has been illuminated promote cell death and apoptosis induced by myocardial ischemia-reperfusion ( Liu L. et al, 2016 ; Liu et al, 2019 ). Guo et al (2017) illustrated an upregulation of miRNA-124 and a positive correlation of miR-124 with cTnI and CK-MB in peripheral blood.…”

Section: Circulating Mirnas Function As Diagnostic and Prognostic Biomentioning

confidence: 99%

Circulating MicroRNAs: Biogenesis and Clinical Significance in Acute Myocardial Infarction

et al. 2020

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Acute myocardial infarction (AMI) causes many deaths around the world. Early diagnosis can prevent the development of AMI and provide theoretical support for the subsequent treatment. miRNAs participate in the AMI pathological processes. We aim to determine the early diagnostic and the prognostic roles of circulating miRNAs in AMI in the existing studies and summarize all the data to provide a greater understanding of their utility for clinical application. We reviewed current knowledge focused on the AMI development and circulating miRNA formation. Meanwhile, we collected and analyzed the potential roles of circulating miRNAs in AMI diagnosis, prognosis and therapeutic strategies. Additionally, we elaborated on the challenges and clinical perspectives of the application of circulating miRNAs in AMI diagnosis. Circulating miRNAs are stable in the circulation and have earlier increases of circulating levels than diagnostic golden criteria. In addition, they are tissue and disease-specific. All these characteristics indicate that circulating miRNAs are promising biomarkers for the early diagnosis of AMI. Although there are several limitations to be resolved before clinical use, the application of circulating miRNAs shows great potential in the early diagnosis and the prognosis of AMI.

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Role of miR-124 and miR-141 in the regulation of vascular reactivity and the relationship to RhoA and Rac1 after hemorrhage and hypoxia

Abstract: of miR-124 and miR-141 in the regulation of vascular reactivity and the relationship to RhoA and Rac1 after hemorrhage and hypoxia.

Cited by 19 publications

References 31 publications

Retracted: Long non‐coding RNA GAS5 aggravates hypoxia injury in PC‐12 cells via down‐regulating miR‐124

Retracted: Long non‐coding RNA GAS5 aggravates hypoxia injury in PC‐12 cells via down‐regulating miR‐124

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Circulating MicroRNAs: Biogenesis and Clinical Significance in Acute Myocardial Infarction

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