Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed  (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System

Tan, Zhijian; Wang, Chaoyun; Yang, Zi-Zhen; Yi, Yanliang; Wang, Hongying; Zhou, Wanlai; Li, Fenfang

doi:10.3390/molecules201017929

Cited by 32 publications

(12 citation statements)

References 42 publications

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“…The screening effect of the IL anion on its extraction efficiency for analytes is considered to be a critical factor, and has significant effects [24,25]. In this study, the 1-butyl-3-methylimidazolium ILs with six different classes of anions (Br − , BF 4 − , OAC − , PF 6 − , Cl − , NO 3 − ) were evaluated, and the differences for TBF content were readily evident.…”

Section: Resultsmentioning

confidence: 99%

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

Jiang

et al. 2018

Molecules

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As a new and green solvent, ionic liquids (ILs) have received more attention during the green extraction and separation process for natural medicines. In this paper, IL-ultrasound-assisted extraction (IL-UAE) of total biflavonoids (TBFs) from Selaginella helvetica was firstly developed, and different ILs were employed and compared. Based on single-factor experiment, solid–liquid ratio (1:10–1:14 g/mL), IL concentration (0.6–1.0 mmol/mL), and extract temperature (40–60 °C) were further explored, according to response surface methodology (RSM), with TBF yields as the index. Moreover, antioxidant activity of TBF extract was analyzed by four methods, i.e., 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzth-iazoline-6-sulphonate (ABTS) free radical scavenging assay, ferric ion reducing power assay, and chelation of ferrous ions assay. The results indicated that [C6mim]PF6 had a high selectivity and efficiency. Moreover, important parameters for the extraction process were investigated and optimized. Through parameter optimization (0.8 mmol/L, 250 W, 40 min, 1:12.7 g/mL, and 47 °C), a yield of 18.69 mg/g biflavonoids was obtained from the extract of S. helvetica. Compared with ethanol-UAE, heat-reflux extraction, Soxhlet extraction, and percolation extraction, IL-UAE could not only obtain higher yield in a shorter time, but also reduce the solvent consumption. In addition, TBF extract showed potential antioxidant activity based on the above four antioxidant methods. In short, IL-UAE was first employed to develop a novel and green extraction method for TBF content, and this experiment provides valuable references for further utilization of S. helvetica.

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Section: Resultsmentioning

confidence: 99%

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

Jiang

et al. 2018

Molecules

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“…The results showed that phase forming ability of ILs increased with the increase in their hydrophobicity. That is, the hydrophobicity of ILs is beneficial to the formation of ATPS [ 3 , 87 , 88 ]. On the other hand, the property of salts has an influence on the phase formation process.…”

Section: Mechanism Of Phase Separationmentioning

confidence: 99%

Phase Behavior of Ionic Liquid-Based Aqueous Two-Phase Systems

Zheng

Yao

et al. 2022

IJMS

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As an environmentally friendly separation medium, the ionic liquid (IL)-based aqueous two-phase system (ATPS) is attracting long-term attention from a growing number of scientists and engineers. Phase equilibrium data of IL-based ATPSs are an important basis for the design and optimization of chemical reactions and separation processes involving ILs. This article provides the recent significant progress that has been made in the field and highlights the possible directions of future developments. The effects of each component (such as salting-out agents and ILs) on the phase behavior of IL-based ATPSs are summarized and discussed in detail. We mainly focus on the phase behavior of ATPSs by using ILs, expecting to provide meaningful and valuable information that may promote further research and application.

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“…Extraction of pharmaceutical molecules (active ingredients or intermediates) is often from plant materials. The isolation of high purity secoisolariciresinol diglucoside, a multi-functional pharmaceutical, from flaxseed, was simplified and improved with an ultrasonic-assisted extraction followed by IL-ATPS formation by the addition of Na 2 SO 4 (Tan et al, 2015 ). A similar example where fractionation and recovery of bioactive hydroxycinnamic derivatives from stressed carrot mass using IL-ATPS formed from [emim]acetate/potassium buffers gave a different phenolic ratio than conventional ATPS (Sánchez-Rangel et al, 2016 ).…”

Section: Il Extractionsmentioning

confidence: 99%

Ionic Liquid Aqueous Two-Phase Systems From a Pharmaceutical Perspective

McQueen

Lai

2019

Front. Chem.

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Aqueous Two-Phase Systems (ATPSs) have been extensively studied for their ability to simultaneously separate and purify active pharmaceutical ingredients (APIs) and key intermediates with high yields and high purity. Depending on the ATPS composition, it can be adapted for the separation and purification of cells, nucleic acids, proteins, antibodies, and small molecules. This method has been shown to be scalable, allowing it to be used in the milliliter scale for early drug development to thousands of liters in manufacture for commercial supply. The benefits of ATPS in pharmaceutical separations is increasingly being recognized and investigated by larger pharmaceutical companies. ATPSs use identical instrumentation and similar methodology, therefore a change from traditional methods has a theoretical low barrier of adoption. The cost of typical components used to form an ATPS at large scale, particularly that of polymer-polymer systems, is the primary challenge to widespread use across industry. However, there are a few polymer-salt examples where the increase in yield at commercial scale justifies the cost of using ATPSs for macromolecule purification. More recently, Ionic Liquids (ILs) have been used for ATPS separations that is more sustainable as a solvent, and more economical than polymers often used in ATPSs for small molecule applications. Such IL-ATPSs still retain much of the attractive characteristics such as customizable chemical and physical properties, stability, safety, and most importantly, can provide higher yield separations of organic compounds, and efficient solvent recycling to lower financial and environmental costs of large scale manufacturing.

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Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System

Cited by 32 publications

References 42 publications

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

Phase Behavior of Ionic Liquid-Based Aqueous Two-Phase Systems

Ionic Liquid Aqueous Two-Phase Systems From a Pharmaceutical Perspective

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