New links between protein N-terminal acetylation, dauer diapause, and the insulin/IGF-1 signaling pathway in<i>Caenorhabditis elegans</i>

Warnhoff, Kurt; Kornfeld, Kerry

doi:10.1080/21624054.2015.1023498

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In C. elegans , N-terminal acetylation mediated by homologues of NatA, NatB, and NatC plays a role in the regulation of animal development, stress tolerance, and entry into a stress resistant developmental stage 30 . About 74% of C. elegans proteins are N-terminal acetylated 24 , and null mutations to any members of NatA or NatB are lethal 31 , 32 , indicating that Nat complexes play an essential role in development.…”

Section: Resultsmentioning

confidence: 99%

“…C. elegans NatC was first identified in a screen for mutants with increased resistance to heavy metal toxicity 29 . Furthermore, loss of NatC was found to confer resistance to a broad spectrum of physiological stressors including oxidative stress and heat shock 29 , 30 . In this context, nipi-3(0) causes physiological stress by overexpressing CEBP-1 or hyperactivating the downstream p38 MAPK pathway, and resistance to this stress may be conferred by loss of NatC.…”

Section: Resultsmentioning

confidence: 99%

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Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Malinow

Zhu

Jin

et al. 2022

Sci Rep

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Coordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood. In Caenorhabditis elegans, it has been hypothesized that a genetic network regulated by NIPI-3/Tibbles may control the balance between animal development and immune response. Using a nipi-3(0) lethality suppressor screen in C. elegans, we reveal a novel role for N-terminal acetyltransferase C complex natc-1/2/3 and histone deacetylase hda-4, in the control of animal development. These signaling proteins act, at least in part, through a PMK-1 p38 MAP kinase pathway (TIR-1–NSY-1–SEK-1–PMK-1), which plays a critical role in the innate immunity against infection. Additionally, using a transcriptional reporter of SEK-1, a signaling molecule within this p38 MAP kinase system that acts directly downstream of C/EBP bZip transcription factor CEBP-1, we find unexpected positive control of sek-1 transcription by SEK-1 along with several other p38 MAP kinase pathway components. Together, these data demonstrate a role for NIPI-3 regulators in animal development, operating, at least in part through a PMK-1 p38 MAPK pathway. Because the C. elegans p38 MAP kinase pathway is well known for its role in cellular stress responses, the novel biological components and mechanisms pertaining to development identified here may also contribute to the balance between stress response and development.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Malinow

Zhu

Jin

et al. 2022

Sci Rep

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“…These candidate genes are N -α-acetyltransferase, which is involved in the N -terminal acetyltransferase C (NatC) complex and acetylation of amino acids, and permease 1 heavy chain, which is involved in maltose metabolic processes (see Table S3 ). Genes involved in the NatC pathway have been implicated in modulating stress tolerance in Caenorhabditis elegans ( Warnhoff and Kornfeld 2015 ). In schistosomes (Trematoda), permease 1 heavy chain is characterized as playing an important role in nutrient uptake from hosts and is expressed during all major schistosome life stages ( Krautz-Peterson et al 2007 ).…”

Section: Resultsmentioning

confidence: 99%

De NovoTranscriptome Characterization of a Sterilizing Trematode Parasite (Microphallussp.) from Two Species of New Zealand Snails

Neiman

2017

G3 Genes|Genomes|Genetics

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Snail-borne trematodes represent a large, diverse, and evolutionarily, ecologically, and medically important group of parasites, often imposing strong selection on their hosts and causing host morbidity and mortality. Even so, there are very few genomic and transcriptomic resources available for this important animal group. We help to fill this gap by providing transcriptome resources from trematode metacercariae infecting two congeneric snail species, Potamopyrgus antipodarum and P. estuarinus. This genus of New Zealand snails has gained prominence in large part through the development of P. antipodarum and its sterilizing trematode parasite Microphallus livelyi into a textbook model for host–parasite coevolutionary interactions in nature. By contrast, the interactions between Microphallus trematodes and P. estuarinus, an estuary-inhabiting species closely related to the freshwater P. antipodarum, are relatively unstudied. Here, we provide the first annotated transcriptome assemblies from Microphallus isolated from P. antipodarum and P. estuarinus. We also use these transcriptomes to produce genomic resources that will be broadly useful to those interested in host–parasite coevolution, local adaption, and molecular evolution and phylogenetics of this and other snail–trematode systems. Analyses of the two Microphallus transcriptomes revealed that the two trematode types are more genetically differentiated from one another than are the M. livelyi infecting different populations of P. antipodarum, suggesting that the Microphallus infecting P. estuarinus represent a distinct lineage. We also provide a promising set of candidate genes likely involved in parasitic infection and response to salinity stress.

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“…These candidate genes are N-alpha-acetyltransferase, which is involved in the N-terminal acetyltransferase C (NatC) complex and acetylation of amino acids, and permease 1 heavy chain, which is involved in maltose metabolic processes (Table S3). Genes involved in the NatC pathway have been implicated in modulating stress tolerance in Caenorhabditis elegans (Warnhoff and Kornfeld 2015). In schistosomes (Trematoda), permease 1 heavy chain is characterized as playing an important role in nutrient uptake from hosts and is expressed during all major schistosome life stages (Krautz-Peterson et al 2007).…”

Section: Resultsmentioning

confidence: 99%

De novotranscriptome characterization of a sterilizing trematode parasite (Microphallussp.) from two species of New Zealand snails

Neiman

2016

Preprint

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Snail-borne trematodes represent a large, diverse, and evolutionarily, ecologically, and medically important group of parasites, often imposing strong selection on their hosts and causing host morbidity and mortality. Even so, there are very few genomic and transcriptomic resources available for this important animal group. We help to fill this gap by providing transcriptome resources from trematode metacercariae infecting two congeneric snail species, Potamopyrgus antipodarum and P. estuarinus. This genus of New Zealand snails has gained prominence in large part through the development of P. antipodarum and its sterilizing trematode parasite Microphallus livelyi into a textbook model for host-parasite coevolutionary interactions in nature. By contrast, the interactions between Microphallus trematodes and P. estuarinus, an estuary-inhabiting species closely related to the freshwater P. antipodarum, are relatively unstudied. Here, we provide the first annotated transcriptome assemblies from Microphallus isolated from P. antipodarum and P. estuarinus. We also use these transcriptomes to produce genomic resources that will be broadly useful to those interested in host-parasite coevolution, local adaption, and molecular evolution and phylogenetics of this and other snail-trematode systems. Analyses of the two Microphallus transcriptomes revealed that the two trematode isolates are more genetically differentiated from one another than are M. livelyi infecting different populations of P. antipodarum, suggesting that the Microphallus infecting P. estuarinus represent a distinct lineage. We also provide a promising set of candidate genes likely involved in parasitic infection and response to salinity stress.

show abstract

New links between protein N-terminal acetylation, dauer diapause, and the insulin/IGF-1 signaling pathway inCaenorhabditis elegans

Cited by 5 publications

References 32 publications

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

De NovoTranscriptome Characterization of a Sterilizing Trematode Parasite (Microphallussp.) from Two Species of New Zealand Snails

De novotranscriptome characterization of a sterilizing trematode parasite (Microphallussp.) from two species of New Zealand snails

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