Sarcoidosis mimicking metastatic papillary thyroid cancer

Salih, Abdulwahid M.; Fatih, Salah M.; Kakamad, Fahmi H.

doi:10.1016/j.ijscr.2015.09.027

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…One such case report reported sarcoidosis presenting as painless thyroid enlargement and cervical lymphadenopathy and features of papillary thyroid carcinoma on fine needle aspiration cytology of the thyroid nodule. On excisional biopsy, however, the cervical lymph nodes showed a picture typical of sarcoidosis 52. A few more case reports mirror our cases in that the patient presents with multisystemic sarcoidosis involving the liver and bones as well 53 54.…”

Section: Systemic Inflammatory Diseasessupporting

confidence: 81%

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

2019

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We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigations and management. After re-exploring her clinical presentation and further investigations (including a liver biopsy), a diagnosis of multisystemic sarcoidosis with ocular, reticuloendothelial, hepatic and skeletal involvement was made. The patient was started on systemic glucocorticoids and second line immunosuppressants and demonstrated significant clinical improvement with resolution of her liver granulomata on imaging and improvement in her back pain. The case illustrates the importance of a thorough clinical assessment, review of investigations and an open mind in the evaluation of a patient.

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Section: Systemic Inflammatory Diseasessupporting

confidence: 81%

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

2019

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“…However, the newly diagnosed papillary thyroid carcinoma complicated his management. This association of sarcoidosis and papillary carcinoma has been reported in the literature 2, 3. Malignancy and sarcoidosis have a complicated and relatively unclear relationship.…”

Section: Discussionsupporting

confidence: 58%

Management of refractory ventricular tachycardia due to cardiac sarcoidosis—A biologic approach

Theodore

Saggu

Yalagudri

et al. 2019

HeartRhythm Case Reports

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“…Three other reports describe patients suffering from papillary thyroid carcinoma that underwent thyreoidectomy and modified neck dissection. Pathology revealed concurrent existence of sarcoidosis and regional lymph node metastasis ( 10 , 16 , 17 ). One patient (27-year-old, male) shows a papillary thyroid carcinoma upon a previously diagnosed sarcoidosis.…”

Section: Resultsmentioning

confidence: 99%

“…Although no increased risk for malignancy in the head and neck has been described so far, there are a few cases that report the simultaneous occurrence of sarcoidosis and malignoma of the head and neck ( 7 – 9 ). Notably, in follow-up computed tomography (CT) scans or those done for the detection of primary tumors or metastatic lesions (e.g., 18-Fluorodeoxyglucose positron emission tomography-(PET)-CT, 18 FDG-PET-CT) sarcoidosis can mimic cancer recurrence or metastatic progress ( 10 , 11 ). However, it is possible that metastatic lesions coexist next to lymph nodes with sarcoid-like lesions and it is unclear whether sarcoidosis has an influence on metastasis of malignoma.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)

Spiekermann¹,

Kuhlencord²,

Huss³

et al. 2017

Oncol Lett

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Sarcoidosis, a chronic, inflammatory disease that affects various different organs, is characterized by noncaseating epitheloid granulomas. This systemic inflammatory process is associated with an increased risk of cancer. Several cases of sarcoidosis that mimic metastatic tumor progression in radiological findings have been reported so far. However, there are also cases that have presented a coexistence of sarcoidosis and metastasis, which have caused a diagnostic and therapeutic dilemma. Due to inadequate current therapies, a reliable differentiation between benign and malignant lesions is crucial. This review focuses on the residual risk of the coexistence of metastases within radiological suspicious lesions in patients with a history of solid tumors and sarcoidosis, as well as immunological findings, in order to explain the potential associations. Sarcoidosis has the potential to promote metastasis as it includes tumor-promoting and immune-regulating cell subsets. Notably, myeloid derived suppressor cells may serve a pivotal role in metastatic progression in patients with sarcoidosis. In addition, the present review also evaluates the potential novel diagnostic approaches, which may be able to differentiate between metastatic lesions and sarcoidosis. The risk of coexistent metastasis in sarcoidosis lesions must be considered by clinical practitioners, and a multidisciplinary approach may be required to avoid misdiagnosis and the subsequent unnecessary surgery or insufficient treatments.

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Sarcoidosis mimicking metastatic papillary thyroid cancer

Abstract: HighlightsSarcoidosis is a multisystemic, idiopathic disease.Thyroid cancer is rarely reported in the literature.We present a case with sarcoidosis mimicking metastatic papillary thyroid cancer.

Cited by 13 publications

References 6 publications

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

Multisystemic sarcoidosis—important lessons learnt from one of the great imitators

Management of refractory ventricular tachycardia due to cardiac sarcoidosis—A biologic approach

Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)

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