The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Ordovás-Montañés, José; Rakoff-Nahoum, Seth; Huang, Siyi; Riol-Blanco, Lorena; Barreiro, Olga; Andrian, Ulrich H. von

doi:10.1016/j.it.2015.08.007

Cited by 144 publications

(129 citation statements)

References 249 publications

(346 reference statements)

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…Peripheral immune cell activation with the release of cytokines and other inflammatory molecules has an impact on sensory (afferent) neurons in the sites of infection or injury and triggers or alters signaling to the CNS – spinal cord and brain (Chiu et al, 2013; Niijima, 1996; Goehler et al, 2000; Ordovas-Montanes et al, 2015; Binshtok et al, 2008; Lai et al, 2017) (Figure 2). A major class of sensory (somatosensory) neurons are nociceptors, preferentially sensitive to noxious stimuli, including heat and mechanical stimulation or to a stimulus that would become noxious if prolonged (Dubin and Patapoutian, 2010).…”

Section: The Immune Impact On Afferent Neuronal Functionmentioning

confidence: 99%

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

2017

View full text Add to dashboard Cite

Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced understanding immunity, and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality to target molecular mechanisms of immunity. Here we review mechanisms of peripheral sensory neuronal function modulation in response to immune challenges and neural regulation of immunity and inflammation, and discuss the therapeutic implications of this mechanistic insight.

show abstract

Section: The Immune Impact On Afferent Neuronal Functionmentioning

confidence: 99%

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

2017

View full text Add to dashboard Cite

show abstract

“…Neuro-immune interactions have been appreciated in human and in mouse inflammatory and infection disease models[53]. Myeloid cells in the dermis and epidermis have been shown to localize closely with cutaneous nerve fibers, specifically fibers expressing Calcitonin Gene Related Peptide (CGRP)[54,55].…”

Section: Innate Immune Response To C Albicansmentioning

confidence: 99%

Skin Immunity to Candida albicans

Kashem

Kaplan

2016

Trends in Immunology

116

101

View full text Add to dashboard Cite

Candida albicans is a dimorphic commensal fungus that colonizes healthy human skin, mucosa and reproductive tract. C. albicans is also a predominant opportunistic fungal pathogen, leading to disease manifestations such as disseminated candidiasis and chronic mucocutaneous candidiasis (CMC). The differing host susceptibilities to the sites of C. albicans infection have revealed tissue compartmentalization with tailoring of immune responses based on site of infection. Furthermore, extensive studies of host genetics in rare cases of CMC have identified conserved genetic pathways involved in the immune recognition and response to the extracellular pathogens. Herein, we focus on the human and mouse skin as a site of C. albicans infection and review the established and newly discovered insights into those cellular pathways that promote cutaneous anti-fungal immunity.

show abstract

“…Over the last fifteen years, the existence of a physiological crosstalk between the nervous system and the immune system has become evident [26,27]. The main example of integrative and complex pathway is called “inflammatory reflex” [28].…”

Section: The Inflammatory Reflexmentioning

confidence: 99%

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis

Kanashiro

Sônego

Ferreira

et al. 2017

Pharmacological Research

View full text Add to dashboard Cite

Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent technical advances and the development of novel generation of antibiotics, severe sepsis remains a major clinical and scientific challenge in modern medicine. Unsuccessful efforts have been dedicated to the search of therapeutic options to treat the deleterious inflammatory components of sepsis. Recent findings on neuronal networks controlling immunity raised expectations for novel therapeutic strategies to promote the regulation of sterile inflammation, such as autoimmune diseases. Interesting studies have dissected the anatomical constituents of the so-called “cholinergic anti-inflammatory pathway”, suggesting that electrical vagus nerve stimulation and pharmacological activation of beta-2 adrenergic and alpha-7 nicotinic receptors could be alternative strategies for improving inflammatory conditions. However, the literature on infectious diseases, such as sepsis, is still controversial and, therefore, the real therapeutic potential of this neuroimmune pathway is not well defined. In this review, we will discuss the beneficial and detrimental effects of neural manipulation in sepsis, which depend on the multiple variables of the immune system and the nature of the infection. These observations suggest future critical studies to validate the clinical implications of vagal parasympathetic signaling in sepsis treatment.

show abstract

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Cited by 144 publications

References 249 publications

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Skin Immunity to Candida albicans

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis

Contact Info

Product

Resources

About