Immunohistochemical and ultrastructural study of the lamellae of oocytes in atretic follicles in relation to different processes of cell death

Escobar, María Luisa; Echeverría, Olga M.; Garcia, Gretchen E.; Ortíz, Rosario; Vázquez‐Nin, Gerardo H.

doi:10.4081/ejh.2015.2535

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…Another comprehensive study confirmed that autophagy and not apoptosis lead to the loss of germ cells after birth 82 . However, Escobar observed a number of different programmed cell death pathways in oocytes when investigating the mechanisms within follicular atresia and the death of oocytes in adolescent rats 85 , 86 . These findings suggested that autophagy led to programmed cell death, in which the regulation of follicular atresia induced by oocytes may vary in different species.…”

Section: Autophagy In Ovarian Follicular Development and Atresiamentioning

confidence: 99%

Autophagy in Ovarian Follicular Development and Atresia

2019

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Autophagy is a mechanism that exists in all eukaryotes under a variety of physiological and pathological conditions. In the mammalian ovaries, less than 1% of follicles ovulate, whereas the remaining 99% undergo follicular atresia. Autophagy and apoptosis have been previously found to be involved in the regulation of both primordial follicular development as well as atresia. The relationship between autophagy, follicular development, and atresia have been summarized in this review with the aim to obtain a more comprehensive understanding of the role played by autophagy in follicular development and atresia.

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Section: Autophagy In Ovarian Follicular Development and Atresiamentioning

confidence: 99%

Autophagy in Ovarian Follicular Development and Atresia

2019

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“…Simultaneously, the same oocytes are positive for cleaved caspase-3 and DNA fragmentation, two hallmarks of apoptosis [ 104 , 204 ]. The seemingly unique feature of atretic oocytes is the disturbance of cytoplasmic structures known as lamellae or lattices which could also be attributed to ongoing autophagy [ 205 ]. It is still unknown whether autophagy plays a driving role in oocyte degradation or just coincides with apoptosis in a futile attempt to rescue the stressed oocyte.…”

Section: Regulation Of Pcd During Follicular Atresiamentioning

confidence: 99%

A matter of new life and cell death: programmed cell death in the mammalian ovary

Chesnokov,

Mamedova,

Zhivotovsky

et al. 2024

J Biomed Sci

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Background The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The estrous/menstrual cycles are associated with drastic functional and morphological rearrangements of ovarian tissue, including follicular development and degeneration, and the formation and subsequent atrophy of the corpus luteum. The flawless execution of these reiterative processes is impossible without the involvement of programmed cell death (PCD). Main text PCD is crucial for efficient and careful clearance of excessive, depleted, or obsolete ovarian structures for ovarian cycling. Moreover, PCD facilitates selection of high-quality oocytes and formation of the ovarian reserve during embryonic and juvenile development. Disruption of PCD regulation can heavily impact the ovarian functions and is associated with various pathologies, from a moderate decrease in fertility to severe hormonal disturbance, complete loss of reproductive function, and tumorigenesis. This comprehensive review aims to provide updated information on the role of PCD in various processes occurring in normal and pathologic ovaries. Three major events of PCD in the ovary—progenitor germ cell depletion, follicular atresia, and corpus luteum degradation—are described, alongside the detailed information on molecular regulation of these processes, highlighting the contribution of apoptosis, autophagy, necroptosis, and ferroptosis. Ultimately, the current knowledge of PCD aberrations associated with pathologies, such as polycystic ovarian syndrome, premature ovarian insufficiency, and tumors of ovarian origin, is outlined. Conclusion PCD is an essential element in ovarian development, functions and pathologies. A thorough understanding of molecular mechanisms regulating PCD events is required for future advances in the diagnosis and management of various disorders of the ovary and the female reproductive system in general.

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“…The death receptors-mediated pathway is triggered by Fas ligand and procaspase-8 events. The caspase-8 activates caspase-3 that finally disrupts the histoarchitecture of a cell resulting in oocyte apoptosis [ 3 , 30 , 46 , 47 ].…”

Section: Germ Cell Depletion Via Apoptosismentioning

confidence: 99%

Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy

et al. 2018

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Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are depleted from ovary through several pathways. Follicular atresia is one of the major events that eliminate germ cells from ovary by engaging apoptotic as well as non-apoptotic pathways of programmed cell death. Apoptosis is characterized by several morphological changes that include cell shrinkage, nuclear condensation, membrane blebbing and cytoplasmic fragmentation by both mitochondria- as well as death receptor-mediated pathways in encircling granulosa cells and oocyte. Although necroapoptosis have been implicated in germ cell depletion, autophagy seems to play an active role in the life and death decisions of ovarian follicles. Autophagy is morphologically characterized by intracellular reorganization of membranes and increased number of autophagic vesicles that engulf bulk cytoplasm as well as organelles. Autophagy begins with the encapsulation of cytoplasmic constituents in a membrane sac known as autophagosomes. The autophagic vesicles are then destroyed by the lysosomal enzymes such as hydrolases that results in follicular atresia. It seems that apoptosis as well as autophagy could play active roles in germ cells depletion from ovary. Hence, it is important to prevent these two pathways in order to retain the germ cells in ovary of several mammalian species that are either threatened or at the verge of extinction. The involvement of apoptosis and autophagy in germ cell depletion from mammalian ovary is reviewed and possible pathways have been proposed.

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Immunohistochemical and ultrastructural study of the lamellae of oocytes in atretic follicles in relation to different processes of cell death

Cited by 9 publications

References 25 publications

Autophagy in Ovarian Follicular Development and Atresia

Autophagy in Ovarian Follicular Development and Atresia

A matter of new life and cell death: programmed cell death in the mammalian ovary

Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy

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