OPG, RANKL, and RANK gene polymorphisms and the bone mineral density response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopenia

Abstract

The RANK gene might contribute to genetic variability in L1-L4 BMD in postmenopausal Chinese women with osteoporosis or osteopenia. No evidence of an association between any SNP or haplotype of the OPG, RANKL, and RANK genes and the response of BMD to alendronate therapy was found in postmenopausal Chinese women with osteoporosis or osteopenia.

Investigation of OPG/RANK/RANKL Genes as a Genetic Marker for Cardiac abnormalities in Thalassemia Major Patients

“…Unadjusted P values suggest that minor C allele of rs1805034 SNP in the RANK gene is a protective allele for diastolic dysfunction. Previous studies shows that C allele of rs1805034 RANK gene polymorphism as a genetic protective factor for osteoporotic hip fracture and higher L1–L4 bone mineral density (Zhang et al., ; Zheng et al., ). No study has been found in literature that shows the association of rs1805034 SNP with the cardiovascular disorders.…”

The genetic association between osteoprotegerin (OPG) gene polymorphisms and bone mineral density (BMD) in postmenopausal women

“…Osteoprotegerin ( OPG ) has been discovered in regulating osteoclastogenesis in 1997. [47,48] Together with receptor activator of nuclear factor-B ligand ( RANKL ), [49] receptor activator of nuclear factor-B ( RANK ), [50] OPG plays a key role in osteoclastogenesis. Transgenic mice ( OPG (−/−)) exhibited a decreased total bone density and developed severe osteoporosis, [51] whereas mice over-expressing OPG develop an osteopetrotic phenotype.…”

RANKL is a new epigenetic biomarker for the vasomotor symptom during Menopause

“…[ 12 ] showed that increased expression of RANKL during osteoporotic fractures but did not show statistically significant association between methylation and osteoporotic fractures. In vitro studies demonstrated the association between RANKL expression and thermoregulation during postmenopause and also homozygous NM _003701.3: c.508A>G mutation in the RANKL gene was associated with impaired fever response [ 47 ].…”