One Extra Gram of Protein to Preterm Infants From Birth to 1800 g

Bellagamba, Maria Paola; Carmenati, Elisabetta; D’Ascenzo, Rita; Malatesta, M. L. Framarino Di; Spagnoli, Cristina; Biagetti, Chiara; Burattini, Ilaria; Carnielli, Virgilio P.

doi:10.1097/mpg.0000000000000989

Cited by 46 publications

(56 citation statements)

References 26 publications

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“…Burattini et al [24], Clark et al [16], Vlaardingerbroek et al [13], Blanco et al [33,34,35]. and Bellagamba et al [23] reported actual rates in gram per kilogram per day. A meta-analysis including these 5 studies showed no differences between the intervention and control groups (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, a lack of consistency in the timeline of this outcome could have influenced the results. Vlaardingerbroek et al [13], Clark et al [16], and Blanco et al [33,34,35] reported mean weight gain for the first 28 days, Burattini et al [24] compared mean weight gain at 36 weeks postmenstrual age (PMA), and Bellagamba et al [23] reported mean weight gain rates from birth and regain of BW to 1,800 g (54 days in both groups). Scattolin et al [26] also reported growth rates, but only for the 2nd and 3rd week of life separately and was, therefore, not included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…IV, inverse variance; M-H, Mantel-Haenszel; PMA, postmenstrual age; NEC, necrotizing enterocolitis; IVH, intraventricular hemorrhage; DOL, days of life. * Bellagamba et al [23]: mean weight gain from birth to 1,800 g (mean 54 days both groups). Blanco et al [35], Clark et al [16], and Vlaardingerbroek et al [13]: mean weight gain on DOL 28.…”

Section: Resultsmentioning

confidence: 99%

“…Burratini et al [24]: mean weight gain at 36 weeks PMA. ** Bellagamba et al [23] excluded the 25 infants who deceased before 36 weeks PMA and 8 with NEC from all further analysis. …”

Section: Resultsmentioning

confidence: 99%

“…Eight studies compared low- versus high-dose amino-acid supplementation [13,16,23,24,25,26,27,28], 5 studies compared early versus late supplementation [12,29,30,31,32], and 3 studied both [16,33,34,35]. Three studies, from Blanco et al [33,34,35], were based on the same study population and were, therefore, seen as one.…”

Section: Resultsmentioning

confidence: 99%

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Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

Leenders

Waard²,

Goudoever³

2017

Neonatology

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Objectives: Providing parenteral amino acids to very-low-birth-weight infants during the first weeks of life is critical for adequate growth and neurodevelopment. However, there is no consensus about what dose is appropriate or when to initiate supplementation. As a result, daily practice varies among neonatal intensive care units. The objective of our study was to determine the effects of early parenteral amino-acid supplementation (within 24 h of birth) versus later initiation and high dose (>3.0 g/kg/day) versus a lower dose on growth and morbidities. Methods: A systematic review and meta-analysis of publications identified by searching PubMed, EMBASE, and Cochrane databases was conducted. Randomized controlled studies were eligible if information on growth was available. Results: The search identified 14 studies. No differences were observed in growth or morbidity after early or high-dose amino-acid supplementation, but for several outcomes, meta-analysis was not possible due to study heterogeneity. Initiation of amino acids within the first 24 h of life appeared to be safe and well tolerated, and leads more rapidly to a positive nitrogen balance. Conclusions: Administering a high dose (>3.0 g/kg/day) or an early dose (≤24 h) of parenteral amino acids is safe and well tolerated but does not offer significant benefits on growth. Further large-scale randomized controlled trials in preterm infants are needed to study the effects of early and high-dose amino acids on growth and morbidity more consistently and extensively.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Burratini et al [24]: mean weight gain at 36 weeks PMA. ** Bellagamba et al [23] excluded the 25 infants who deceased before 36 weeks PMA and 8 with NEC from all further analysis. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

Leenders

Waard²,

Goudoever³

2017

Neonatology

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Higher versus lower amino acid intake in parenteral nutrition for newborn infants

Osborn

Schindler

Jones

et al. 2018

Cochrane Database of Systematic Reviews

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Higher Energy, Lipid, and Carbohydrate Provision to Very Low‐Birth‐Weight Infants Is Differentially Associated With Neurodevelopment at 18 Months, Despite Consistent Improvements in Weight Gain

Bishara

Asbury

et al. 2021

J Parenter Enteral Nutr

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Background:The impact of suboptimal intakes on neurodevelopment of very low-birth-weight (VLBW, <1500 g) infants, particularly those born small for gestational age, <26 weeks, <1000 g, or with morbidities is not well defined. We investigated how macronutrient/energy intakes are associated with growth and neurodevelopment among VLBW infants, adjusted for the aforementioned vulnerabilities. Our hypothesis was that higher nutrient intakes would be positively associated with weight gain and neurodevelopment. Methods: Daily macronutrient/energy intakes and weekly weights from birth until 36 +0 weeks were collected prospectively from VLBW infants (n = 302) enrolled in a previous trial (ISRCTN35317141). Neurodevelopment was assessed by the Bayley-III at 18 months' corrected gestational age. Relationships between quartiles of macronutrient/energy intakes, growth, and neurodevelopment were assessed. Results: Infants born <1000 g, <26 weeks, or with morbidities had lower nutrient intakes and slower growth than infants born ≥1000 g, ≥26 weeks, or with no morbidities, respectively (P < 0.05). Higher quartiles of energy, lipid, and carbohydrate intakes were positively associated with growth velocity (P = <0.0001-0.007); no association was observed for protein intake. Energy, protein-to-energy ratio and lipid intakes were associated with cognitive scores (P = 0.001-0.004); however, intakes within the second and third quartiles were generally associated with the highest cognitive scores. No nutrient intakes were associated with language or motor scores across the entire study period. Conclusion: Smaller, more immature VLBW infants and those with morbidity have the greatest risk of poor nutrition and growth. Increasing macronutrient/energy intakes are generally associated with improved weight gain, but not necessarily improved neurodevelopment.

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One Extra Gram of Protein to Preterm Infants From Birth to 1800 g

Abstract: Increasing AA/protein intake both during parenteral and enteral nutrition does not improve growth and neurodevelopment of small preterm infants 500 to 1249 g birth weight.

Cited by 46 publications

References 26 publications

Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

Low- versus High-Dose and Early versus Late Parenteral Amino-Acid Administration in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

Higher versus lower amino acid intake in parenteral nutrition for newborn infants

Higher Energy, Lipid, and Carbohydrate Provision to Very Low‐Birth‐Weight Infants Is Differentially Associated With Neurodevelopment at 18 Months, Despite Consistent Improvements in Weight Gain

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