Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation

Kawamoto, Y.; Ueno, Yuki; Nakahashi, Emiko; Obayashi, Momoko; Sugihara, Kento; Qiao, Shanlou; Iida, Machiko; Kumasaka, Mayuko Y.; Yajima, Ichiro; Goto, Yuji; Ohgami, Nobutaka; Kato, Masashi; Takeda, Kazuhisa

doi:10.1016/j.jnutbio.2015.08.025

Cited by 61 publications

(42 citation statements)

References 46 publications

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“…These phenolic compounds have various biological properties especially in anti-inflammatory, anti-oxidant and anti-tumor effects. As one of potent nutraceuticals, 6-gingerol had a variety of pharmacological abilities and has been known to have antihyperglycemic, anti-cancer and anti-oxidative properties [6]. 6-shogaol also was known as antiproliferative, anti-metastatic, and pro-apoptotic activities via suppression of STAT3 gene products in tumor tissues [7].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Phytochemicals from Grains of Paradise Using Supercritical Carbon Dioxide

Ono¹,

Kawamoto²,

Uemori³

et al. 2017

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Abstract. Supercritical carbon dioxide (SCCO2) is one of the green methods to extract plant matters substances. In this study, SCCO2 has been applied as a media to extract the grains of paradise seeds substances at temperatures of 40 -80 o C and pressures of 20 -40 MPa using a semi-continuous flow-type system. Results of FT-IR spectra analysis showed that the grains of paradise seeds substances were extracted by SCCO2. The SEM images of the grains of paradise seeds residues also showed that the physical changes of the grains of paradise seeds surface occurred after SCCO2 extraction. The main compounds in extracts were gingerols, shogaols, and paradols. However, the GC-MS may only identify paradol compounds due to gingerols, shogaols, and paradols are homologous series of phenolic ketones and paradols was more stable than gingerols and shogaols. The yields of gingerols, shogaols, and paradols were 9.12, 3.90, and 4.42 mg/g sample, respectively and affected by extraction temperatures and/or extraction pressures.

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Section: Introductionmentioning

confidence: 99%

Extraction of Phytochemicals from Grains of Paradise Using Supercritical Carbon Dioxide

Ono¹,

Kawamoto²,

Uemori³

et al. 2017

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“…T cells have been reported to participate in various immune-related diseases [9]. Dendritic cells provide signals that regulate T cell proliferation, which is the immune basis of allergic rhinitis [10, 11]. Therefore, in the present study, we detected the biological role of HIF1α deficiency in dendritic cells (HIF1α CD11c–/– ) in allergic rhinitis.…”

Section: Introductionmentioning

confidence: 81%

HIF1α Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner

Niu

Wang

et al. 2020

Int Arch Allergy Immunol

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Background: Allergic rhinitis is the most prevalent atopic disorder worldwide. Inflammation is believed to participate in allergic rhinitis. Previous studies indicate that hypoxia-inducible factor (HIF) promotes the development of allergic rhinitis, and dendritic cells are also involved in allergic rhinitis. Methods: We explored the consequences of HIF1α deficiency in dendritic cells on allergic rhinitis. Allergic rhinitis in mice was induced by ovalbumin (OVA). The levels of IgE, leukotriene C4 (LTC4), eosinophil cationic protein (ECP), prostaglandin D2 (PGD2), IFN-γ, IL-2, IL-4, IL-5, IL-10, and IL-13 in serum or nasal lavage fluid (NLF) were detected by ELISA. Inflammatory cells in NLF were counted by hemocytometer. The protein levels of p-ERK1/2, p-p38, p-JNK2, SIRT1, p-IκBα, and p65 were determined by Western blot. Results: HIF1α deficiency in dendritic cells (HIF1α CD11c-/-) decreased sneezing and nasal rubbing, the production of OVA-specific IgE, LTC4, and ECP in serum and NLF, and the numbers of leukocytes, eosinophils, lymphocytes, and neutrophils in NLF. Th1 cytokines increased, while Th2 cytokines decreased in HIF1a CD11c-/mice. SIRT1/NF-κB signaling was inhibited in HIF1α CD11c-/mice, while SIRT1 inhibitor administration in HIF1α CD11c-/mice attenuated the symptoms and inflammatory indicators of allergic rhinitis. Conclusion: HIF1α deficiency in dendritic cells attenuates symptoms and inflammatory indicators of allergic rhinitis in a SIRT1-dependent manner.

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“…The result presented that 2% dietary ginger reduced the severity of nasal rubbing and sneezing by nasal sensitization of OVA and suppressed infiltration of mast cells in nasal mucosa and secretion of OVA specific IgE in serum. After spleen cells were induced with OVA, 6-Gingerol (50 μM) inhibited the expression Th2 cytokine (IL-4, IL-10 and IL-13) and Th1cytokine (IFN-γ) [8].…”

Section: Discussionmentioning

confidence: 99%

“…In an in vivo study, oral administration of 2% ginger diet decreased the severity of nasal rubbing and sneezing by nasal sensitization of ovalbumin (OVA) and suppressed infiltration of mast cells in nasal mucosa and release of OVA-specific IgE in serum. Furthermore, 6gingerol (50 μM) could inhibited cytokine production for T cell activation and proliferation, therefore B cell and mast cell could not be activated [8]. In acute and subacute toxicity studies, single oral doses of crude ethanolic extract of ginger at 1000, 3000, and 5000 mg/kg body weight did not cause mortality in any animal during the investigation period [9].…”

Section: Introductionmentioning

confidence: 99%

Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial

Yamprasert

Chanvimalueng

Mukkasombut

et al. 2020

BMC Complement Med Ther

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Background: Allergic rhinitis (AR) is a non-infectious immune disease and incidents of the disease has continuously increased in Thailand. Ginger, a Thai herb, is used in food and Thai traditional medicine. This study was designed to assess efficacy and safety of ginger extract in comparison with loratadine for AR treatment. Methods: AR patients were treated with ginger extract 500 mg (n = 40) against those treated with loratadine 10 mg (n = 40) in a randomized, double-blind, controlled trial for 3 and 6 weeks. The efficacy was evaluated from clinical examinations i.e. total nasal symptom scores (TNSS), cross-sectional area of the nasal cavity with acoustic rhinometry (ARM) and rhinoconjunctivitis quality of life questionnaire (RQLQ). The safety of treatment was measured by blood pressure, blood analysis and history-taking for side effects. Results: The results showed both ginger extract and loratadine treated groups significantly decreased TNSS scores but there was no significant difference between the two groups. In acoustic rhinometry measurement, the ginger treated group significantly gradually increased the estimated volume of the nasal cavity and decreased distances from the nostril, but the loratadine treated group did not cause a change. Both groups gave significantly improvement in every aspect of the RQLQ at third weeks. The treatment with ginger extract was as safe as loratadine as shown by renal and liver function results obtained from blood analysis. Both treatments had no effect on blood pressure of the patients. Conclusions: The ginger extract is as good as loratadine in improving nasal symptoms and quality of life in AR patients. However, ginger extract caused less side effects especially, drowsiness, fatigue, dizziness and constipation. Therefore, the ginger extract could be used as alternative treatment for patients with AR.

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Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation

Cited by 61 publications

References 46 publications

Extraction of Phytochemicals from Grains of Paradise Using Supercritical Carbon Dioxide

Extraction of Phytochemicals from Grains of Paradise Using Supercritical Carbon Dioxide

HIF1α Deficiency in Dendritic Cells Attenuates Symptoms and Inflammatory Indicators of Allergic Rhinitis in a SIRT1-Dependent Manner

Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial

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