Soluble ST2 Has a Prognostic Role in Patients With Suspected Sepsis

Hur, Mina; Kim, Hyeong-Su; Yang, Hyun Suk; Magrini, L.; Marino, Rossella; Cardelli, Patrizia; Somma, Salvatore Di

doi:10.3343/alm.2015.35.6.570

Cited by 42 publications

(37 citation statements)

References 22 publications

(42 reference statements)

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“…This is generally dependent on the application of scoring systems. Although various clinical biomarkers are widely explored [ 5 – 8 ], only a few have been currently applied in the clinical practice. Therefore, the search continues for preferable infection markers that may facilitate the prognosis prediction of sepsis.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study

Liu

Shen

Wang

et al. 2016

Mediators of Inflammation

183

156

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Background. The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible biological marker that has been reported to represent disease severity. The aim of this study is to investigate the association between NLR and mortality in patients with sepsis. Methods. A total of 333 consecutive adult patients with sepsis were screened for eligibility in this prospective, observational study cohort. Severity scores and leukocyte counts were prospectively recorded upon entry to the intensive care unit (ICU). Receiver operating characteristic (ROC) curves and binary logistic regression models were used to assess the performance of NLR in predicting unfavorable outcome. Correlations between variables and disease severity were analyzed through Spearman correlation tests. Results. Median NLR levels were significantly higher in patients who died than in survivors. NLR had a modest power for predicting poor outcome as suggested by area under the curve (AUC) of 0.695 ± 0.036. Multivariate linear regression indicated that increased NLR levels were related to unfavorable outcome independently of the effect of possible confounders. Spearman correlation tests showed that there was a positive correlation between NLR levels and disease severity. Conclusions. Increased NLR levels were independently associated with unfavorable clinical prognosis in patients with sepsis. Further investigation is required to increase understanding of the pathophysiology of this relationship.

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Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study

Liu

Shen

Wang

et al. 2016

Mediators of Inflammation

183

156

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“…The IL-33/ST2 signaling pathway has been implicated in numerous inflammatory diseases [6,7]. As the key molecule in this axis, elevated serum sST2 has been reported as a valuable inflammatory biomarker in several Th2-related diseases such as asthma and sepsis, and its high-level has also been observed in several cardiovascular diseases such as atherosclerosis and heart failure [8][9][10][11]. Acute ischemic stroke (AIS) is a leading cause of morbidity, mortality, and disability worldwide, which causes cerebral ischemia with activation of an inflammatory response leading to the exacerbation of primary brain injury.…”

Section: Introductionmentioning

confidence: 99%

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Chen¹,

Ao²,

Yu³

et al. 2018

Clin. Lab.

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Background: Soluble ST2 (sST2) receptor is secreted and detectable in human serum, which acts as a decoy receptor for interleukin (IL)-33 to prevent IL-33-mediated Th2 immune responses. Recently, elevated serum sST2 has been found to be a novel biomarker in cardiovascular diseases such as heart failure and atherosclerosis. Here, we studied the role of sST2 in acute ischemic stroke (AIS) and its relationship with several inflammatory markers. Methods: The study included 112 patients with first-ever acute ischemic stroke, who were admitted within 48 hours after stroke onset. The serum levels of sST2 and IL-33 were measured with ELISA and the severity of AIS patients was evaluated based on the National Institutes of Health Stroke Scale (NIHSS) score. The cerebral infarct volume was calculated according to the Pullicino formula based on the cranial CT scan or MRI. High-sensitivity C-reactive protein (hs-CRP) and serum amyloid A protein (SAA) were measured using the latex-enhanced immunoturbidimetric assay. Results: The serum sST2 level was significantly increased in patients with AIS compared to the control patients without AIS. In addition, the concentration of serum sST2 increased with the infarct volume and the severity of AIS evaluated based on the NIHSS score. Furthermore, the sST2 level correlated positively with the inflammatory marker hs-CRP. Conclusions: Our study suggests that sST2 may be used as a novel diagnostic and predicting inflammatory marker in AIS.

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“…However, an acute increase in the ST2 level has been observed when damage is accompanied by the inhibition of IL-33 and its favorable antihypertrophic effects. Studying the role of ST2 during hospitalization for MI can be helpful for predicting the course of the hospitalization and development of complications [ 3 9 10 11 ]. The aim of this study was to determine the level of soluble ST2 (sST2) and its correlation with the level of NT-proBNP and with the clinical course of MI during hospitalization.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction

et al. 2016

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BackgroundStudying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications.MethodsWe included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA.ResultsOn day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004).ConclusionsThe level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.

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Soluble ST2 Has a Prognostic Role in Patients With Suspected Sepsis

Cited by 42 publications

References 22 publications

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction

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