Definitions and Outcome Measures in Pediatric Functional Upper Gastrointestinal Tract Disorders

Rashid, Aafia; Taminiau, J. A. J. M.; Benninga, Marc A.; Saps, Miguel; Tabbers, Merit M.

doi:10.1097/mpg.0000000000000973

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…1 Some studies on pediatric functional upper GI disorders found that functional dyspepsia was the most common FGID at 3-27%, whereas the prevalence of cyclic vomiting syndrome was only 2-3%. [13][14][15][16][17] While the prevalence rates found in our study are generally comparable with those reported by the previous studies, no other pediatric study has examined FGID as a whole or specifically limited to functional upper GI tract disorders among patients with asthma, limiting our ability to compare our results directly with prior researches.…”

Section: Discussionsupporting

confidence: 82%

“…In contrast, this extensive clinical evaluation is not routine practice in a research setting. 1,3,13 One could argue that it would be ideal to obtain GI histology for all patients for diagnostic clarity, as a rigorous search to exclude organic diseases is particularly important among atopic patients. However, the role and prevalence of inflammatory disease in eosinophilic GI disease remain unclear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of functional GI disorders among pediatric patients with persistent asthma

Colman¹,

Rosario

Bonilla³

et al. 2018

J of Digest Diseases

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Prevalence of functional GI disorders among pediatric patients with persistent asthma

Colman¹,

Rosario

Bonilla³

et al. 2018

J of Digest Diseases

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“…The Cochrane Center for Registered Trials includes 300 prospective randomized controlled trials assessing treatment of functional dyspepsia in adults and 10 in children. There are at least 7 high-quality double-blinded randomized controlled trials in the treatment of functional dyspepsia in children (60).…”

Section: Functional Dyspepsia and Managementmentioning

confidence: 99%

Biliary Dyskinesia in Children

Santucci

Hyman

Harmon

et al. 2017

J. pediatr. gastroenterol. nutr.

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Cholecystectomy rates for biliary dyskinesia in children are rising in the United States, but not in other countries. Biliary dyskinesia is a validated functional gallbladder disorder in adults, requiring biliary colic in the diagnosis. In contrast, most studies in children require upper abdominal pain, absent gallstones on ultrasound, and an abnormal gallbladder ejection fraction (GBEF) on cholecystokinin-stimulated cholescintigraphy for diagnosis. We aimed to systematically review existing literature in biliary dyskinesia in children, determine the validity and reliability of diagnostic criteria, GBEF, and to assess outcomes following cholecystectomy. We performed a systematic review following the PRISMA checklist and searched 7 databases including PubMed, Scopus, Embase, Ovid, MEDLINE, ProQuest, Web of Science, and the Cochrane library. Bibliographies of articles were screened for additional studies. Our search terms yielded 916 articles of which 28 were included. Three articles were manually added from searched references. We reviewed 31 peer-reviewed publications, all retrospective chart reviews. There was heterogeneity in diagnostic criteria and GBEF values. Outcomes after laparoscopic cholecystectomy varied from 34% to 100% success, and there was no consensus concerning factors influencing outcomes. The observational, retrospective study designs that comprised our review limited interpretation of safety and efficacy of the investigations and treatment in biliary dyskinesia in children. Symptoms of biliary dyskinesia overlapped with functional dyspepsia. There is a need for consensus on symptoms defining biliary dyskinesia, validation of testing required for diagnosis of biliary dyskinesia, and randomized controlled trials comparing medical versus surgical management in children with upper abdominal pain.

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“…In that 1882 publication, Dr. Gee described a case series of nine children with “fitful or recurrent vomiting.” The publication of case studies over the more recent decades has established both an adult-onset variation of CVS (Abell, Kim, & Malagelada, 1988; Hermus et al, 2016; Keller, Desuki, Hobohm, Münzel, & Ostad, 2015; Prakash & Clouse, 1999; Shearer, Luthra, & Ford, 2018) and a probable toxicity-induced variant described as CHS (Allen, de Moore, Heddle, & Twartz, 2004; Schreck et al, 2018; Sontineni, Chaudhary, Sontineni, & Lanspa, 2009). The classic pediatric variety, with typical resolution in puberty and associations with migraine and anxiety, has been well characterized within the gastrointestinal (GI), neurological, and pediatric literature (Boronat, Ferreira-Maia, Matijasevich, & Wang, 2017; Irwin, Barmherzig, & Gelfand, 2017; Li et al, 2008; Li, Murray, Heitlinger, Robbins, & Hayes, 1998; Rashid et al, 2016; Romano, Dipasquale, Rybak, Comito, & Borrelli, 2018; Zeevenhooven, Koppen, & Benninga, 2017). Therefore, this article adds to the discussion by providing an evaluation of adult CVS and its potential relationship to CHS in the context of endocannabinoid dysregulation.…”

Section: Historical Contextmentioning

confidence: 99%

Cyclic Vomiting Syndrome and Cannabis Hyperemesis Syndrome

Lathrop

Rosen

Heitkemper

et al. 2023

Gastroenterology Nursing

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This article provides a narrative review of the state of the science for both cyclic vomiting syndrome and cannabis hyperemesis syndrome along with a discussion of the relationship between these 2 conditions. The scope of this review includes the historical context of these conditions as well as the prevalence, diagnostic criteria, pathogenesis, and treatment strategies for both conditions. A synopsis of the endocannabinoid system provides a basis for the hypothesis that a lack of cannabidiol in modern high-potency Δ9-tetrahydrocannabinol cannabis may be contributory to cannabis hyperemesis syndrome and possibly other cannabis use disorders. In concluding assessment, though the publications addressing both adult cyclic vomiting syndrome and cannabis hyperemesis syndrome are steadily increasing overall, the state of the science supporting the treatments, prognosis, etiology, and confounding factors (including cannabis use) is of moderate quality. Much of the literature portrays these conditions separately and as such sometimes fails to account for the confounding of adult cyclic vomiting syndrome with cannabis hyperemesis syndrome. The diagnostic and therapeutic approaches are, at present, based generally on case series publications and expert opinion, with a very limited number of randomized controlled trials and a complete absence of Level 1 evidence within the cyclic vomiting literature overall as well as for cannabis hyperemesis syndrome specifically.

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Definitions and Outcome Measures in Pediatric Functional Upper Gastrointestinal Tract Disorders

Cited by 7 publications

References 42 publications

Prevalence of functional GI disorders among pediatric patients with persistent asthma

Prevalence of functional GI disorders among pediatric patients with persistent asthma

Biliary Dyskinesia in Children

Cyclic Vomiting Syndrome and Cannabis Hyperemesis Syndrome

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