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Methyl 5-Chloro-4,5-didehydrojasmonate (J7) Inhibits Macrophage-Derived Chemokine Production <i>via</i> Down-Regulation of the Signal Transducers and Activators of Transcription 1 Pathway in HaCaT Human Keratinocytes

“…Various studies have reported that several stimuli, including IFN-γ and TNF-α, can also activate the extracellular signal-regulated kinase (ERK), p38 MAPK, and NF-κB pathways. [30][31][32] Under normal conditions, NF-κB combines with inhibitor of kappa B-α (IκB-α) in the cytoplasm. IFN-γ and TNF-α, among other cytokines, can induce the phosphorylation and degradation of IκB-α, leading to the subsequent phosphorylation of NF-κB and its translocation into the nucleus.…”