Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study

Abstract

BackgroundThe characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.MethodsThis study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥−1.0 and <−1.0 dB/year.ResultsMean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, −0.08 (interquartile range −0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, −4.48 ± 3.81 diopters and −11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (−13.85 ± 9.32 vs. −10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (−0.85 vs. −0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <−1.0 dB/year than in the group with MD slope ≥−1.0 dB/year (−11.56 vs. −7.64 dB/year, P < 0.01).ConclusionsWe identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation

“…Glaucoma is an optic neuropathy characterized by the progressive death of retinal ganglion cell (RGC) axons and the irreversible loss of vision 6 . Although elevated intraocular pressure (IOP) is the most important risk factor for glaucoma, in some patients progress continues despite normal IOP, suggesting that IOP-independent factors also influence glaucoma progression 7 , 8 . Furthermore, many previous reports have indicated that oxidative stress-associated compounds increase in the eyes and bodily fluids of human glaucoma patients 9 – 12 , in particular oxidized DNA 13 .…”

Characteristics of Primary Open-Angle Glaucoma Patients in Dr. Soetomo General Hospital Surabaya

“…A study at Tohoku University Hospital found that the mean age of POAG patients was 63.4 ± 12.4 years. 13 It is known that the factor of increasing age has more opportunities to make people suffer from POAG. It is known that POAG is a disease with chronic and progressive optic nerve damage which has slow progressivity and asymptomatic.…”

“…Intraocular pressure is determined by the velocity of the formation of aqueous humor by the ciliary body and the obstacles that occur in trabecular meshwork. 14 The results of a study conducted by Yokoyama, et al (2015) at Tohoku University Hospital received a range of intraocular pressure values of 11-20 mmHg. 13 In this study, the highest intraocular pressure results of POAG patients were found in the normal range.…”

CHOP Deletion and Anti-Neuroinflammation Treatment With Hesperidin Synergistically Attenuate NMDA Retinal Injury in Mice

“…One of the most important risk factors is elevated intraocular pressure (IOP), which promotes mechanical stress in RGCs and leads to the development of glaucoma. However, many patients, especially in Asia, experience a continued progression of visual eld defects despite normal IOP, suggesting that IOPindependent factors also in uence glaucoma progression [2]; thus, glaucoma is a multifactorial disease.…”