Split-dose sodium picosulfate–magnesium citrate colonoscopy preparation achieves lower residual gastric volume with higher cleansing effectiveness than a previous-day regimen

It’s time to take the split-standard out of the split-prep

“…The study by Prieto-Frias et al 5 supports existing data indicating that the split-prep achieves greater cleansing effectiveness than the previous-day regimen. 3,4 In addition, both Prieto-Frias et al 5 and Agrawal et al 6 suggest that residual gastric volume may be comparable or even lower with the split-prep than with the previous-day prep regimen. The Agrawal et al 6 study used a polyethylene glycol (PEG) prep, with the last dose being completed 2 to 3 hours before the procedure.…”

“…The Agrawal et al 6 study used a polyethylene glycol (PEG) prep, with the last dose being completed 2 to 3 hours before the procedure. Prieto-Frias et al 5 used a sodium picosulfate-magnesium citrate prep, with completion of the prep 2 to 6 hours before the procedure.…”

“…In this study, the amount of residual gastric fluid volume, as measured by endoscopic aspiration of the gastric contents, was significantly less in the split-prep group (11.09 mL) compared with the previous-day prep group (18.62 mL), with the best results being achieved in the 3-to 4-hour time interval before the procedure. 5 In the study by Agrawal et al, a high-volume PEG split-prep regimen was administered among inpatients requiring colonoscopy, with completion of the last dose at 2 to 3 hours before the procedure. These investigators found no significant difference in the gastric residual volume between the split-prep and previous-day groups (mean of 21 mL vs 24 mL, respectively).…”

Split‐dose bowel preparation with polyethylene glycol for colonoscopy performed under propofol sedation. Is there an optimal timing?

“…The effect of medications including PPIs is likely to be small, given that our data are similar to others where the medication intake was recorded, and this is unlikely to affect the validity of the results. [35][36][37]48 The correlation between age and RGV independent of PPI therapy was also noted in a similar context. 44 Our study adds to the accumulating evidence that favors the intake of 1 L bowel preparation regimen containing PEG close to deep sedation.…”

“…Excluding PPIs, other medications have not been found to correlate with RGV. The effect of medications including PPIs is likely to be small, given that our data are similar to others where the medication intake was recorded, and this is unlikely to affect the validity of the results . The correlation between age and RGV independent of PPI therapy was also noted in a similar context …”