Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease

Santetti, Daniele; Wilasco, Maria Inês de Albuquerque; Dornelles, Cristina; Werlang, Isabel Cristina Ribas; Fontella, Fernanda Urruth; Kieling, Carlos Oscar; Santos, Jorge Luiz dos; Vieira, S; Goldani, Helena Ayako Sueno

doi:10.3748/wjg.v21.i29.8927

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…Comparison between the groups of opposed BMI SDS revealed statistically higher serum IL-6 level in the malnourished patients. Similar results were also presented by Santetti, who reported high level of IL-6 in children with chronic liver disease at nutritional risk (Santetti et al, 2015). We have to note that in our study the regarded sample of malnourished children was very small and comprised only 14 subjects presenting BMI<-1.5 SD.…”

Section: Discussionsupporting

confidence: 86%

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

et al. 2019

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Background: Cystic fibrosis (CF) is characterized by malnutrition and chronic inflammation predominantly occurring in lungs. Evidence suggests a relation between inflammatory activity and nutritional status. Proinflammatory cytokines, playing crucial role in pulmonary destruction in CF, are regarded as a component of the pathogenesis of illness-related malnutrition. Chemerin - a novel marker of a crosstalk between nutrition and inflammation, has not been investigated in children with cystic fibrosis. The aim of this study was to determine serum level of chemerin, interleukin-1b (IL-1b), interleukin-6 (IL-6), tumor necrosing factor α (TNF-α) and interleukin-10 (IL-10) and to verify if they correlate with the nutritional status in children with CF. Methods: The study included 72 pediatric patients with cystic fibrosis. The control group was comprised of 30 healthy children. Nutritional status parameters: Body Mass Index (BMI), fat mass percentage (FM %) and fat free mass percentage (FFM%) have been assessed in all the subjects basing on bioimpedance and anthropometry according to Slaughter. Serum concentrations of chemerin and cytokines were estimated with ELISA. Results: No statistically significant difference in serum chemerin was found between the studied and the control group. We have documented a significantly higher level of IL-1b, IL-6, TNF-α and IL-10 in CF patients when compared to healthy controls. Neither the chemerin nor the cytokine levels correlated with parameters of nutritional status in our cohort. No statistically significant correlation was found between the serum chemerin and the inflammatory cytokines: IL-1b, IL-6, and TNFα. Conclusions: Our results show that chemerin is not associated with the nutritional status in children with cystic fibrosis. Chemerin has no impact on the levels of IL-1b, IL-6, TNFα in CF patients. IL-1b, IL6, TNFα and also IL10 are upregulated in cystic fibrosis.

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Section: Discussionsupporting

confidence: 86%

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

et al. 2019

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“…The pro-inflammatory cytokines produces free radicals that generate peroxides, Prostaglandin E2, interleukin 6, tumour necrotizing factor -alpha and cysteinyl leukotrienes -powerful agents in the inflammatory response [30] -which are significantly associated with increased nutritional risk [31]. These inflammatory activities seen in ECC are a component of the pathogenesis of illness-related malnutrition [32,33] and can impair growth [34].…”

Section: Introductionmentioning

confidence: 99%

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Foláyan¹,

Arije

Tantawi

et al. 2019

Preprint

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Background : To determine the association between malnutrition and early childhood caries (ECC) in children resident in sub-urban, Nigeria. Methods : This study is a secondary analysis of a larger cross-sectional data generated through a household survey. Variables (sex, frequency of sugar consumption, maternal knowledge of oral hygiene, oral hygiene status) associated with ECC in the primary study conducted in the Ile-Ife, Nigeria, were adjusted for in the models. We used Poisson regression analysis to determine the association between ECC and malnutrition (stunting, overweight and underweight). We reported the adjusted prevalence ratio (APR). Results: Of the 370 children, 20 (5.41%) were underweight, 20 (5.41%) were overweight, 67 (18.11%) were wasting, 120 (32.43%) were stunted and 18 (4.86%) had ECC. Factors associated with ECC were being stunted, underweight, overweight and fair oral hygiene. The prevalence of ECC was lower in children who were stunted (APR: 0.14; 95% CI: 0.03-0.69; p=0.02), almost seven times higher in children who were overweight (APR: 6.88; 95% CI: 1.83-25.85; p<0.001), and predictively absent in children who were underweight (APR: 0; 95% CI: 0-0; p<0.001) when compared with children who had normal weight. Non-significant risk indicators for ECC included consuming sugar between meals three times a day or more, having low socioeconomic status and being female. Conclusions : For this study population, the indicators of malnutrition – being stunted, underweight, overweight - and fair oral hygiene were risk indicators for ECC, while the frequency of sugar consumption was not a significant risk indicator. Further studies are needed to identify if there are other mediators of associations between ECC and nutrition status apart from sugar consumption.

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“…Inflammation, being an energy demanding condition, was recently suggested as a potentially major cause of malnutrition and changes in body composition in patients with chronic inflammatory diseases [41]. Also, levels of inflammatory cytokines are higher in children with chronic liver disease and poor nutritional status than in those with normal nutritional status [42]. Chronic inflammation may also be associated with increased BMD loss, since in inflammatory diseases, TNF-a activates osteoclastic bone destruction and inhibits osteoblastogenesis [43].…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis in cirrhotics before and after liver transplantation: relation with malnutrition and inflammatory status

Huldén

Castedal

Karlsson

et al. 2020

Scandinavian Journal of Gastroenterology

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Background: Liver cirrhosis is associated with osteoporosis and liver transplantation (LT) with increased bone loss. This study aimed to in LT candidates investigate the potential relation between bone mineral density (BMD) and BMD loss in those who undergo LT, with malnutrition, systemic inflammation, and hormonal status. Methods: We included 102 consecutively recruited cirrhotic LT candidates between May 2004 and April 2007. BMD was assessed by means of dual energy X-ray absorptiometry (DXA). Malnutrition was defined by means of anthropometry and assessment of recent weight loss. In 75/102 patients, serumthyroid stimulating hormone (TSH), free triiodthyronine (T3) and free thyroxine (T4) and growth hormone (GH), cortisol, free testosterone, dehydroepiandrosterone sulfate, estradiol, interleukin-6, and tumor necrosis factor (TNF)-a was assessed. Overall 57/102 patients received a LT and 47/102 were followed for one year post-LT. At follow-up, nutritional status and BMD were assessed in all patients (n ¼ 47) while 34/47 had available blood samples for analysis. Results: Forty (40%) LT-candidates had osteopenia or osteoporosis and 34 (38%) were malnourished. Malnutrition was associated with osteopenia/osteoporosis (odds ratio: 3.5, 95% CI 1.4, 9.9). Hip BMD Zscore decreased À0.25 (95% CI À0.41, À0.09) from baseline to one year post-LT. High baseline TNF-a correlated with a more marked decline in BMD (Partial correlation (r) ¼ À0.47, p < .05) as did high baseline cortisol levels (r ¼ À0.49, p < .05). Conclusion: Malnutrition in liver cirrhosis seems to be associated with osteopenia/osteoporosis, and systemic inflammation (higher TNF-a) and systemic stress (higher cortisol) to bone loss in patients who undergo LT.

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Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease

Abstract: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients.

Cited by 21 publications

References 46 publications

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Osteoporosis in cirrhotics before and after liver transplantation: relation with malnutrition and inflammatory status

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