Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study

Orona, Nadia Soledad; Ferraro, Sebastián Ariel; Astort, Francisco; Morales, Celina; Brites, Fernando; Boero, Laura; Tiscornia, Gisela; Maglione, Guillermo Alberto; Saldiva, Paulo Hilário Nascimento; Yakisich, Sebastian; Tasat, Deborah Ruth

doi:10.1016/j.envpol.2015.07.020

Cited by 25 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…al., found both PM extracts from a roadside monitor and a simulated metal solution, including Al, Fe, and Pb, increased IL-6 and TNF-α in murine bronchoalveolar fluid over a 24-hour period with returns to baseline by the 48-hr measurement [ 35 ]. In another l mouse model, acute instillation of urban air particles (at 1mg/kg) resulted in 3-hr increases in TNF-α and IL-6 with resolution before a 24-hr measurement [ 36 ]. In contrast, ΔTNF-α and ΔIL-6 were not associated with any metal exposures in our commuting population, but Pb was associated with Δhs-CRP and ΔsICAM.…”

Section: Discussionmentioning

confidence: 99%

“…This decrease is contrary to expectation [ 37 , 38 ]. One possible explanation may be the potential confluence of circadian patterns of inflammatory markers and the rapid resolution of inflammatory signaling [ 36 ] that may result in our observed depression. Our findings indicate that increased short-term metal exposures, specifically Pb, may be responsible for an acute inflammatory response that resolves within a 10-hr window in humans.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

et al. 2018

View full text Add to dashboard Cite

IntroductionAdvances in liquid chromatography-mass spectrometry (LC-MS) have enabled high-resolution metabolomics (HRM) to emerge as a sensitive tool for measuring environmental exposures and corresponding biological response. Using measurements collected as part of a large, panel-based study of car commuters, the current analysis examines in-vehicle air pollution concentrations, targeted inflammatory biomarker levels, and metabolomic profiles to trace potential metabolic perturbations associated with on-road traffic exposures.MethodsA 60-person panel of adults participated in a crossover study, where each participant conducted a highway commute and randomized to either a side-street commute or clinic exposure session. In addition to in-vehicle exposure characterizations, participants contributed pre- and post-exposure dried blood spots for 2-hr changes in targeted proinflammatory and vascular injury biomarkers and 10-hr changes in the plasma metabolome. Samples were analyzed on a Thermo QExactive MS system in positive and negative electrospray ionization (ESI) mode. Data were processed and analyzed in R using apLCMS, xMSanalyzer, and limma. Features associated with environmental exposures or biological endpoints were identified with a linear mixed effects model and annotated through human metabolic pathway analysis in mummichog.ResultsHRM detected 10-hr perturbations in 110 features associated with in-vehicle, particulate metal exposures (Al, Pb, and Fe) which reflect changes in arachidonic acid, leukotriene, and tryptophan metabolism. Two-hour changes in proinflammatory biomarkers hs-CRP, IL-6, IL-8, and IL-1β were also associated with 10-hr changes in the plasma metabolome, suggesting diverse amino acid, leukotriene, and antioxidant metabolism effects. A putatively identified metabolite, 20-OH-LTB4, decreased after in-vehicle exposure to particulate metals, suggesting a subclinical immune response.ConclusionsAcute exposures to traffic-related air pollutants are associated with broad inflammatory response, including several traditional markers of inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

et al. 2018

View full text Add to dashboard Cite

show abstract

“… [50] Intranasal instillation The aim of this study was to analyse in vivo the acute biological impact of two environmental particles, urban air particles from Buenos Aires and Residual Oil Fly Ash, on the cardiorespiratory system of middle-aged mice, evaluating oxidative metabolism and inflammation. [51] Intranasal instillation We tested the hypothesis that a single acute exposure to low doses of fine particulate matter (PM 2.5 ) may induce functional and histological lung changes and unchain inflammatory and oxidative stress processes. PM 2.5 was collected from the urban area of São Paulo city during 24 h and underwent analysis for elements and polycyclic aromatic hydrocarbon contents.…”

Section: Datamentioning

confidence: 99%

Inhale, exhale: Why particulate matter exposure in animal models are so acute? Data and facts behind the history

et al. 2019

View full text Add to dashboard Cite

We present a dataset obtained by extracting information from an extensive literature search of toxicological experiments using mice and rat animal models to study the effects of exposure to airborne particulate matter (PM). Our dataset covers results reported from 75 research articles considering paper published in 2017 and seminal papers from previous years. The compiled data and normalization were processed with an equation based on a PM dosimetry model. This equation allows the comparison of different toxicological experiments using instillation and inhalation as PM exposure protocols with respect to inhalation rates, concentrations and PM exposure doses of the toxicological experiments performed by different protocols using instillation and inhalation PM as exposure methods. This data complements the discussions and interpretations presented in the research article “Inhale, exhale: why particulate matter exposure in animal models are so acute?” Curbani et al., 2019.

show abstract

“…Dentre os poluentes atmosféricos, destaca-se o Residual Oil Fly Ash (ROFA), formado pela queima de combustíveis fósseis e rico em metais pesados (Ghio et al, 2002). O ROFA é um tipo de material particulado fino (MP 2,5 ) que, por apresentar diâmetro reduzido, pode ser facilmente absorvido e afetar o trato respiratório por meio do estresse oxidativo e de processos inflamatórios (Ghio et al, 2002;Damiani et al, 2012;Orona et al, 2016).…”

Section: Introductionunclassified

ESTRESSE OXIDATIVO E PARÂMETROS ANALÍTICOS EM AVEIA BRANCA (Avena sativa L.): ESTADO DA ARTE

Pereira¹,

Tissot-Squalli²

2018

Gestão Do Conhecimento, Tecnologia E Inovação

View full text Add to dashboard Cite

show abstract

Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study

Cited by 25 publications

References 38 publications

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

Inhale, exhale: Why particulate matter exposure in animal models are so acute? Data and facts behind the history

ESTRESSE OXIDATIVO E PARÂMETROS ANALÍTICOS EM AVEIA BRANCA (Avena sativa L.): ESTADO DA ARTE

Contact Info

Product

Resources

About