Development of an Experimental Drug Eluting Suprachoroidal Microstent as Glaucoma Drainage Device

Hovakimyan, Marina; Siewert, Stefan; Schmidt, W. J.; Sternberg, Katrin; Reske, Thomas; Stachs, Oliver; Guthoff, Rudolf; Wree, Andreas; Witt, Martin; Schmitz, Klaus‐Peter; Allemann, Reto

doi:10.1167/tvst.4.3.14

Cited by 22 publications

(24 citation statements)

References 35 publications

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“…These studies also showed dose-sparing with SCS injection compared with eye drops. Micro-stents penetrated through the scleral spur to generate a fluid conduit from the anterior chamber into the SCS have been shown to reduce IOP in glaucoma patients[48, 57, 91]. …”

Section: Pharmacodynamicsmentioning

confidence: 99%

The suprachoroidal space as a route of administration to the posterior segment of the eye

Chiang

Jung

Prausnitz

2018

Advanced Drug Delivery Reviews

102

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The suprachoroidal space (SCS) is a potential space between the sclera and choroid that traverses the circumference of the posterior segment of the eye. The SCS is an attractive site for drug delivery because it targets the choroid, retinal pigment epithelium, and retina with high bioavailability, while maintaining low levels elsewhere in the eye. Indeed, phase III clinical trials are investigating the safety and efficacy of SCS drug delivery. Here, we review the anatomy and physiology of the SCS; methods to access the SCS; kinetics of SCS drug delivery; strategies to target within the SCS; current and potential clinical indications; and the safety and efficacy of this approach in preclinical animal studies and clinical trials.

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Section: Pharmacodynamicsmentioning

confidence: 99%

The suprachoroidal space as a route of administration to the posterior segment of the eye

Chiang

Jung

Prausnitz

2018

Advanced Drug Delivery Reviews

102

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“…Glaucoma is a major eye disorder causing irreversible blindness treated by important device inventions in industrialized countries [1][2][3]. In this research, basic concepts of adaptive implant for minimally invasive glaucoma treatment [4] were studied as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics Analysis of Titanium Outflow Pipe Implant for Glaucoma Treatment in Biomechanical Engineering

Karaçal

2019

Acta Phys. Pol. A

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Outflow pipe implant with check valve is a new glaucoma ocular tension treatment, developed primarily to correct the deteriorated intraocular fluid circulation in glaucoma disease. The research focus is to analyze a new outflow pipe implant with check valve material behavior for improving intraocular fluid outflow structure. Very few computational studies have considered both the mechanical and fluid flow impact of outflow pipe implant with check valve. There is non-available literature on outflow pipe implant with check valve structure and appropriate material selection to release the aqueous humor in intraocular stabilized pressure. The CFD-ANSYS simulation model was investigated for realization of realistic fluid flow velocity and pressure of aqueous humor behavior in microenvironment of the suprachoroidal space. The static structure and the von Mises stress for failure mode were studied to explore geometrical shape and material deformation structure by finite element method in ANSYS.Research results show affirmatively that structural analysis data correlates with fluid dynamics data in agreement.

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“…Our initial experiments using these biodegradable polymers as GDD provided promising results [35]. An LDD coating in the outflow area was designed to prevent fibrosis in the postoperative period.…”

Section: Introductionmentioning

confidence: 99%

Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents

et al. 2018

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To prevent implant failure due to fibrosis is a major objective in glaucoma research. The present study investigated the antifibrotic effects of paclitaxel (PTX), caffeic acid phenethyl ester (CAPE), and pirfenidone (PFD) coated microstent test specimens in a rat model. Test specimens based on a biodegradable blend of poly(4-hydroxybutyrate) biopolymer and atactic poly(3-hydroxybutyrate) (at.P(3HB)) were manufactured, equipped with local drug delivery (LDD) coatings, and implanted in the subcutaneous white fat depot. Postoperatively, test specimens were explanted and analyzed for residual drug content. Fat depots including the test specimens were histologically analyzed. In vitro drug release studies revealed an initial burst for LDD devices. In vivo, slow drug release of PTX was found, whereas it already completed 1 week postoperatively for CAPE and PFD LDD devices. Histological examinations revealed a massive cell infiltration in the periphery of the test specimens. Compact fibrotic capsules around the LDD devices were detectable at 4–36 weeks and least pronounced around PFD-coated specimens. Capsules stained positive for extracellular matrix (ECM) components. The presented model offers possibilities to investigate release kinetics and the antifibrotic potential of drugs in vivo as well as the identification of more effective agents for a novel generation of drug-eluting glaucoma microstents.

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Development of an Experimental Drug Eluting Suprachoroidal Microstent as Glaucoma Drainage Device

Cited by 22 publications

References 35 publications

The suprachoroidal space as a route of administration to the posterior segment of the eye

The suprachoroidal space as a route of administration to the posterior segment of the eye

Computational Fluid Dynamics Analysis of Titanium Outflow Pipe Implant for Glaucoma Treatment in Biomechanical Engineering

Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents

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