Correction: Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

Tobi, Elmar W.; Goeman, Jelle J.; Monajemi, Ramin; Gu, Hongcang; Putter, Hein; Zhang, Yanju; Slieker, Roderick C.; Stok, Arthur P.; Thijssen, Peter; Müller, Fabian; Zwet, Erik W. van; Bock, Christoph; Meissner, Alexander; Lumey, L. H.; Slagboom, P. Eline; Heijmans, Bastiaan T.

doi:10.1038/ncomms8740

Cited by 14 publications

(6 citation statements)

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“…Undernutrition usually develops from inadequate protein and micronutrients intake due to unavailability of food [3,4]. Epigenetic modification during pre- and neo-natal period, such as metabolic imprinting, will also increase the risk of malnutrition and diet-related non-communicable diseases later in life [5,6].…”

Section: Introductionmentioning

confidence: 99%

Millet-based supplement restored microbiota diversity of acute undernourished pigs

Yang

Ren

et al. 2019

Preprint

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The strong connection between undernutrition and gut microbiota (GM) has enabled microbiota-targeting to become an evolving strategy, which witnessed urgent need for fortified formula of supplementary food in undernutrition therapy. Using undernourished pigs as models, we investigated how corn- and millet-based nutritional supplement acted differently in modulating microbiota. Undernourished pigs at age of 9 weeks were fed with pure maize diet (Maize), corn-based (CSB+) and millet-based (MSB+) supplementary food for 3 weeks. Compared with Maize group, both CSB+ and MSB+ improved serum total protein and globulin level, but no physiological improvement was observed by short-term food intervention. MSB+ shown superior influence on GM immaturity which were more normally-grown like at both structural and functional level. Higher level of Bacteriodetes, Firmicutes and lower level of Preteobacteria were detected in MSB+ fed piglets in contrast with CSB+. Lachnospira.spp was significantly raised after nutritional intervention, indicating high correlation with the undernutrition-associated phenotype. Thus, especially from the GM aspect, millet could be one promising source to help undernourished children reconstruct balanced microbiota in short therapeutic term.

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Section: Introductionmentioning

confidence: 99%

Millet-based supplement restored microbiota diversity of acute undernourished pigs

Yang

Ren

et al. 2019

Preprint

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“…For instance, there is strong evidence that nutritional habits can influence gene transcription epigenetically ( van Dijk et al, 2015 ; Etchegaray and Mostoslavsky, 2016 ) and there are several studies claiming inheritance to the offspring ( Figure 1 ) ( Seki et al, 2012 ; Nicholas et al, 2013 ; Rando and Simmons, 2015 ). A recent genome wide analysis of DNA methylation in children born to parents affected by the Dutch famine showed that 70 years later several DNA regions associated with growth and metabolism were significantly differentially methylated, including genes involved in control of birth weight and LDL cholesterol in later life ( Tobi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Epigenetics and Metabolism in Health and Disease

Tzika¹,

Dreker²,

Imhof

2018

Front. Genet.

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In the next 10 years, one billion people are estimated to suffer from disabling consequences of metabolic disorders, making them the number one noncommunicable disease on a global scale by 2030. Lots of risk factors such as dietary intake, lack of exercise and other life style behaviors are considered to play a role in the development of metabolic disorders. Despite the efforts that have been undertaken to unravel their potential causes, the underlying molecular mechanisms remain elusive. Evidence suggests that the pathogenesis involves changes on chromatin and chromatin-modifying enzymes, which can contribute to a persistent dysregulated metabolic phenotype. Indeed, a rising number of studies links epigenetic alterations with the diagnosis and prognosis of metabolic disorders. A prerequisite for exploiting these findings for pharmacological intervention is a detailed understanding of how differential epigenetic modifications control cell metabolism. In this mini review, we summarize the recent advances in uncovering the interplay between epigenetics and metabolic pathways on a cellular level and highlight potential new avenues for alternative treatment strategies.

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“…Later studies determined that several genes linked to metabolic and cardiovascular disease were perturbed epigenetically in this cohort. In particular, DNA methylation at INSR was positively correlated with birth weight, and methylation at CPT1A was positively correlated with LDL cholesterol levels (194,195). A separate study by the same group demonstrated that several genes linked to CVD were differentially methylated in association with prenatal exposure to famine including INSIGF, GNASAS, MEG3, IL10, LEP, and ABCA1 (196).…”

Section: A Metabolic Syndrome and Related Diseasesmentioning

confidence: 96%

Dietary Modulation of the Epigenome

Ideraabdullah

Zeisel

2018

Physiological Reviews

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Epigenetics is the study of heritable mechanisms that can modify gene activity and phenotype without modifying the genetic code. The basis for the concept of epigenetics originated more than 2,000 yr ago as a theory to explain organismal development. However, the definition of epigenetics continues to evolve as we identify more of the components that make up the epigenome and dissect the complex manner by which they regulate and are regulated by cellular functions. A substantial and growing body of research shows that nutrition plays a significant role in regulating the epigenome. Here, we critically assess this diverse body of evidence elucidating the role of nutrition in modulating the epigenome and summarize the impact such changes have on molecular and physiological outcomes with regards to human health.

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Correction: Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

Cited by 14 publications

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Millet-based supplement restored microbiota diversity of acute undernourished pigs

Millet-based supplement restored microbiota diversity of acute undernourished pigs

Epigenetics and Metabolism in Health and Disease

Dietary Modulation of the Epigenome

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