Prognostic significance of serum albumin level changes in acute ischemic stroke: the role of biological and analytical variation

Makris, Konstantinos; Koniari, Katerina; Spanou, Loukia; Gialouri, Eleni; Evodia, Efimia; Lelekis, M.

doi:10.1515/cclm-2015-0281

Cited by 16 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, malnutrition during hospitalization might be the most probable explanation for the continuous decreasing albumin level during the first 7 days. A decreasing trend in Alb after AIS was also reported by Makris et al 29 …”

Section: Discussionsupporting

confidence: 82%

Elevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis

Yang¹,

Shen²,

Huang³

et al. 2022

JIR

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Elevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis

Yang¹,

Shen²,

Huang³

et al. 2022

JIR

View full text Add to dashboard Cite

“…A previous study found that serum albumin levels might change during the first days after stroke, especially in patients with poor outcome. 39 Therefore, our data may partially magnify the negative relationship between hypoalbuminemia and outcome. Third, serum albumin measurement of sub-centres was not uniform.…”

Section: Open Accessmentioning

confidence: 83%

Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack

et al. 2021

View full text Add to dashboard Cite

BackgroundTo examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association.MethodsWe analysed data from the Third China National Stroke Registry (CNSR-Ⅲ). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis.ResultsA total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in <35 g/L group had an increased risk of poor functional outcome and mortality (adjusted OR 1.37 (95% CI 1.12 to 1.67); adjusted HR 2.13 (95% CI 1.41 to 3.23)). The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed (adjusted OR 1.17 (95% CI 1.01 to 1.35); adjusted HR 1.86 (95% CI 1.30 to 2.64)). Also, low serum albumin levels were independently correlated with clinical outcomes at 1 year. In the meta-analysis, the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03 (95% CI 1.02 to 1.05), and the HR for mortality pooled 5 studies was 1.07 (95% CI 1.03 to 1.11).ConclusionsLow serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA.

show abstract

“…Hypoalbuminemia and hypoproteinemia seen in the gentamicin-untreated group could be attributed to reduced albumin synthesis by the liver and to the leaking of albumin into the urine. Acute kidney injury has been viewed as an acute systemic disease with significant effects on other organs such as the liver in a process named organ crosstalk (Lane et al, 2013 andMakris &Spanou, 2016). Some lipid abnormalities are also caused by changes in liver metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Treatment with Frankincense on Gentamicin-Induced Nephrotoxicity in Rats

2022

Egyptian Journal of Nutrition

View full text Add to dashboard Cite

Drug-induced nephrotoxicity is a common cause of acute kidney injury and gentamicin is categorized under one of these nephrotoxic drugs. Using medicinal plants that can ameliorate or delay the deterioration in kidney functions is needed due to their low cost and fewer side effects.Thirty-Five healthy adult male albino rats were divided into five equal groups: (-) control group in which normal rats were fed on a basal diet as a group (1), (+) controlnephrotoxicity rats in which rats were injected with gentamicin and fed on a basal diet as a group (2), groups (3,4, and 5) nephrotoxicity rats were fed on a basal diet containing 2.5, 5, and 10% frankincense (Boswellia sacra) powder, respectively, for 28 days. Kidney and liver functions, minerals levels, antioxidant status, lipids profile, glucose levels, and histopathological changes were investigated. Results showed a significant increase in body weight and a significant decrease in serum level of urea, creatinine, uric acid, phosphorous, potassium, lipids, glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin, and total protein in groups treated with different levels of frankincense (P ≤0.05). Moreover, there was a significant increase in levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), and Catalase (CAT) as well as a significant decrease in levels of malondialdehyde (MDA), a biomarker of lipid peroxidation (P ≤0.05). Concerning kidney histology, no histopathological alterations were seen in the kidneys of rats treated with 10 % frankincense powder. Study results demonstrated that administration of frankincense for 28 days could ameliorate kidney damage resulting from gentamicin-induced nephrotoxicity in rats.

show abstract

Prognostic significance of serum albumin level changes in acute ischemic stroke: the role of biological and analytical variation

Abstract: This study shows that sAlb levels might change during the first days after an acute IS, but these changes although statistically significant are not clinically significant if we take into account the analytical and biological variation of sAlb.

Cited by 16 publications

References 15 publications

Elevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis

Elevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis

Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack

The Effect of Treatment with Frankincense on Gentamicin-Induced Nephrotoxicity in Rats

Contact Info

Product

Resources

About