Maternal high-fat diet is associated with impaired fetal lung development

Mayor, Reina; Finch, Katelyn E.; Zehr, Jordan; Morselli, Eugenia; Neinast, Michael D.; Frank, Aaron; Hahner, Lisa; Wang, Jason; Rakheja, Dinesh; Palmer, Biff F.; Rosenfeld, Charles R.; Savani, Rashmin C.; Clegg, Deborah J.

doi:10.1152/ajplung.00105.2015

Cited by 51 publications

(58 citation statements)

References 43 publications

(52 reference statements)

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“…In those pilot experiments we noted abnormal baseline Rrs and alveolar development. A recent publication expands and details these types of findings (Mayor et al 2015).…”

Section: Discussionmentioning

confidence: 89%

Maternal high‐fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring

MacDonald

Moran

Scherman

et al. 2017

Physiological Reports

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Maternal obesity prior to and during pregnancy has been associated with an increased incidence of childhood asthma. As diets rich in saturated fat are linked to obesity and inflammation, we created a murine model to investigate the effect of maternal high‐fat diet (HFD) on adult offspring airway hyperreactivity (AHR), a cardinal feature of asthma. Balb/cByJ dams were fed a HFD (60% fat Calories) or normal‐fat diet (NFD) (10% fat Calories) from 8 weeks prior to first breeding through their pregnancies. Pups were weaned to either a HFD or NFD (at 4 weeks of age). AHR was measured in the 10‐week‐old offspring following inhaled methacholine challenge by end‐inflation technique. Bronchial alveolar lavage fluid (BALF) was analyzed for cell count, total protein, and IL‐6. Offspring of HFD dams weaned to NFD had increased AHR compared to offspring of NFD dams weaned to NFD. Offspring of HFD dams that remained on HFDs had increased AHR compared to offspring of NFD dams weaned to HFDs. Offspring of HFD dams had higher BALF cell counts, higher neutrophil percentage, greater total protein, and IL‐6 in the BALF. These results demonstrate that a maternal diet high in saturated fat through pregnancy and lactation plays a key role in programming adult offspring AHR.

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“…In those pilot experiments we noted abnormal baseline Rrs and alveolar development. A recent publication expands and details these types of findings (Mayor et al 2015).…”

Section: Discussionmentioning

confidence: 89%

Maternal high‐fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring

MacDonald

Moran

Scherman

et al. 2017

Physiological Reports

View full text Add to dashboard Cite

show abstract

“…For example, a high-fat diet alters fetal lung development: rats born to mothers fed a high-fat diet during gestation have higher levels of cytokines such as tumor necrosis factor-a in their lungs, as well as increased airway resistance and decreased respiratory system compliance (31). Furthermore, mice born to mothers fed a high-fat diet have delayed fetal lung development and reduced expression of surfactant proteins (32). Consumption of a high-fat diet during gestation could contribute to the development of asthma in offspring.…”

Section: Asthma Caused By Obesitymentioning

confidence: 99%

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

Dixon

Poynter

2016

Am J Respir Cell Mol Biol

128

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The majority of patients with severe or difficult-to-control asthma in the United States are obese. Epidemiological studies have clearly established that obese patients tend to have worse asthma control and increased hospitalizations and do not respond to standard controller therapy as well as lean patients with asthma. Less clear are the mechanistic underpinnings for the striking clinical differences between lean and obese patients with asthma. Because obesity is principally a disorder of metabolism and energy regulation, processes fundamental to the function of every cell and system within the body, it is not surprising that it affects the respiratory system; it is perhaps surprising that it has taken so long to appreciate how dysfunctional metabolism and energy regulation lead to severe airway disease. Although early investigations focused on identifying a common factor in obesity that could promote airway disease, an appreciation has emerged that the asthma of obesity is a manifestation of multiple anomalies related to obesity affecting all the different pathways that cause asthma, and likely also to de novo airway dysfunction. Consequently, all the phenotypes of asthma currently recognized in lean patients (which are profoundly modified by obesity), as well as those unique to one's obesity endotype, likely contribute to obese asthma in a particular individual. This perspective reviews what we have learned from clinical studies and animal models about the phenotypes of asthma in obesity, which show how specific aspects of obesity and altered metabolism might lead to de novo airway disease and profoundly modify existing airway disease.

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“…Maternal obesity and/or maternal HF diet studies are usually focused on the consequences to the offspring. [46][47][48] These studies vary greatly in terms of the mothers' diet before pregnancy, the duration and the amount of fat in the diet. Similar to our study, Tamashiro et al 49 exposed rats to a 60% HF diet starting on day 2 of gestation, measured body weight on days 14-21, and found no significant weight gain.…”

Section: Diet Reproductive Status and Weightmentioning

confidence: 99%

“…Animal studies that model maternal obesity, rather than administering HF diets during gestation, usually feed the HF diet many weeks before mating. Pereira et al 51 started female rats on a 45% fat diet 4 weeks before mating and found that they gained significantly more weight during pregnancy than control females, while Mayer et al 46 had female mice on a 42% fat diet for over 3 months before mating, and found that the animals lost a significant amount of weight compared to standard fed females. Gohir et al 52 found no differences in weight gain after eight weeks of a 45% fat diet or during pregnancy.…”

Section: Diet Reproductive Status and Weightmentioning

confidence: 99%

Maternal high fat diet and its consequence on the gut microbiome: A rat model

2017

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The biological changes that occur during pregnancy in the female mammal include shifts in hormonal regulation in preparation for parturition and lactation, and changes in energy metabolism. In women, studies have also shown that during pregnancy there is a reduction in bacterial species richness in the gut. In the current experiment rats were used to model the interaction of diet, reproductive status, and intestinal bacterial microbiota during pregnancy and lactation. In Experiment 1 rats were exposed to either standard chow or high-fat chow (60%) and were divided into two groups: unmated (NULL) or mated (RE). In Experiment 2, both NULL and RE rats were exposed to high-fat chow for a 30-day period. High-throughput sequencing of the 16S rRNA gene revealed that pregnancy impacted the gut microbiota in a similar manner to humans. The impact of reproductive status on microbiota composition, however, was stronger in rats fed a high-fat (HF) diet. Diet-induced changes replicated some of the changes observed in humans, such as increasing the Firmicutes/Bacteroidetes ratio. However, in contrast to humans, pregnancy in rats did not increase β-diversity between microbiota from different animals. These results indicate that during pregnancy in rats, the gut microbiota is altered in a similar manner to that which occurs in women, and that these changes are further exaggerated by exposure to a HF diet. Thus, the rat may allow modelling the effects of consumption of HF food during pregnancy and enable future studies to determine the risks of HF diets during pregnancy and its consequences on the offspring.

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Maternal high-fat diet is associated with impaired fetal lung development

Cited by 51 publications

References 43 publications

Maternal high‐fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring

Maternal high‐fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

Maternal high fat diet and its consequence on the gut microbiome: A rat model

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