Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood

Frederiksen, Brittni N.; Seifert, Jennifer; Kroehl, Miranda; Lamb, Molly M.; Milne, Ginger L.; Rewers, Marian; Norris, Jill M.

doi:10.1038/pr.2015.116

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…The sample was aliquoted and stored at a -80°C freezer without preservative. For assessment of oxidative stress, urine was analyzed for levels of F 2 -IsoPs, a stable marker of lipid peroxidation, following previously published protocols [29, 30, 36, 64]. Briefly, 1 ng of [ 2 H4]-8-isoPGF 2 α an internal standard, was added to 1ml of thawed urine, followed by F 2 -IsoP extraction using C18 and Sep-pak cartridges.…”

Section: Methodsmentioning

confidence: 99%

Childhood adversity, mental health, and oxidative stress: A pilot study

et al. 2019

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Childhood adversity is a potent risk factor for mental health conditions via disruptions to stress response systems. Dysregulations in oxidative stress systems have been associated with both childhood adversity and several psychological disorders (e.g., major depressive disorder) in adult populations. However, few studies have examined associations between childhood adversity, oxidative stress, and mental health in pediatric populations. Childhood adversity (Adverse Childhood Events [ACE]), oxidative stress [F2 t -isoprostanes (IsoPs)], and mental health pathology were assessed in 50 adolescent females recruited primarily through the Department of Youth Services. Standard ordinary least squares regression models were run co-varying for age, race/ethnicity, adolescent nicotine use, study condition, and parent history of ACEs. Adolescents who reported experiencing four or more ACEs had significantly elevated IsoP levels. Further, internalizing symptom scores across diagnoses were significantly associated with elevated IsoPs, whereas no externalizing symptoms scores, except Attention Deficit Hyperactivity Disorder, were related to altered oxidative stress. Results indicate that IsoPs may be a global marker of childhood adversity and mental health symptomatology, particularly within internalizing symptom domains. A limitation is that body mass index was not collected for this sample. Future studies are needed to replicate and extend these findings in larger, more diverse samples.

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Section: Methodsmentioning

confidence: 99%

Childhood adversity, mental health, and oxidative stress: A pilot study

et al. 2019

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“…( 2009 ) 1 PCAustralian BabyDiabYesGluten, non‐gluten cerealIslet autoimmunity Frederiksen et al. ( 2015 ) 1 PCDiabetes Autoimmunity Study in the Young (DAISY)YesCF, glutenT1DM Hakola et al. ( 2018 ) 1 PCType 1 Diabetes Prediction and Prevention Study (DIPP) nutritionYesCF, glutenAdvanced islet autoimmunityCF, glutenT1DM Lund‐Blix et al.…”

Section: Appendix B – Publications Considered In the Assessmentmentioning

confidence: 99%

“…The reliability of the different methods was considered in the appraisal of the risk of bias (RoB) (Appendix B). One exception was applied to a study that measured F2‐isoprostane concentrations in spot urine samples (and not in 24‐hour urine) as a marker of oxidative damage to lipids (Frederiksen et al., ). Spot urine samples are not considered an appropriate sampling unit for this outcome (EFSA NDA Panel, ).…”

Section: Introductionmentioning

confidence: 99%

Appropriate age range for introduction of complementary feeding into an infant's diet

Nutrition¹,

Castenmiller²,

Henauw³

et al. 2019

EFS2

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“…Early introduction to complementary or solid foods in infancy has been associated with increased risk of childhood obesity [1][2][3], oxidative stress [4], and immune-mediated conditions [5][6][7], but the mechanism underlying these associations is not yet well understood [6,8,9]. It has been postulated that alterations in the infant gut microbiota may be on the pathway [4,5,10,11]. Longitudinal studies of infants have found that adult-associated microbes begin to dominate the infant microbiota after weaning [12,13], suggesting that early weaning could prematurely displace beneficial infant-associated microbes, altering the metabolic functionality of the gut microbiota during a critical period of development.…”

Section: Introductionmentioning

confidence: 99%

Timing of complementary feeding is associated with gut microbiota diversity and composition and short chain fatty acid concentrations over the first year of life

et al. 2020

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Background: Early introduction of complementary foods has been associated with various immune disorders, oxidative stress, and obesity in childhood. The gut microbiota and the short chain fatty acids (SCFAs) they produce are postulated to be on the causal pathway. The objective of this study was to determine if early complementary feeding (i.e. consumption of solids or non-water/formula liquids at or before 3 months) is prospectively associated with infant gut microbiota composition, diversity and SCFAs at 3 and 12 months of age in the Nurture birth cohort. Results: Mother-infant dyads in the early complementary feeding group (n = 18) had similar baseline characteristics to those in the later feeding group (n = 49). We assessed differential abundance of microbial taxa (measured by 16S rRNA gene sequencing of the V4 region) by timing of complementary feeding using beta-binomial regression models (considering a two-sided FDR corrected p-value of < 0.05 as significant), and we fittted linear regression models to assess the association between early complementary feeding and SCFA concentrations (quantified using gas chromatography). After multivariable adjustment for breastfeeding, delivery method, birth weight, and gestational age, there were 13 differentially abundant microbial amplicon sequence variants (ASVs) by timing of introduction to complementary foods at 3 months and 20 ASVs at 12 months. Infants introduced to complementary foods early (vs. later) had higher concentrations of the SCFA butyric acid (mean difference = 0.65, 95% CI: 0.27, 1.04, p < 0.01) and total SCFAs (mean difference = 38.8, 95% CI: 7.83, 69.7) at 12 months. Bilophila wadsworthia and Lachnospiraceae Roseburia were associated with early (vs. later) complementary feeding and with higher butyric acid concentrations at 3 and 12 months, respectively. Conclusions: Our findings are consistent with the hypothesis that early (vs. later) introduction to complementary foods is associated with altered gut microbiota composition and butyric acid concentrations measured in stool until at least 1 year of age. Further research is needed to determine if these changes mediate future development of metabolic and immune conditions.

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Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood

Cited by 6 publications

References 42 publications

Childhood adversity, mental health, and oxidative stress: A pilot study

Childhood adversity, mental health, and oxidative stress: A pilot study

Appropriate age range for introduction of complementary feeding into an infant's diet

Timing of complementary feeding is associated with gut microbiota diversity and composition and short chain fatty acid concentrations over the first year of life

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