Botulinum Toxin A: An Effective Treatment for Linear Immunoglobulin A Bullous Dermatosis Located in the Axillae

Legendre, L.; Maza, A.; Almalki, Aïcha; Livideanu, Cristina Bulai; Paul, C.; Mazereeuw‐Hautier, J.

doi:10.2340/00015555-2178

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…41,42 Case reports have reported the treatment of the bilateral axillae in a young patient with linear IgA bullous dermatosis using 50 U per axilla, and 100 U injected into the foot of a middle-aged female affected by localised epidermolysis bullosa simplex. 43,44 Raynaud's phenomenon…”

Section: Bullous Skin Diseasementioning

confidence: 99%

Botulinum Toxins in Medical and Cosmetic Dermatology

2021

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Background: Botulinum toxin (BoNT), a bacterially produced neurotoxin, is a mainstay in the dermatologic armamentarium. Although BoNT is commonly used to treated rhytides associated with ageing, it can be employed for a variety of other cosmetic purposes and medical disorders. Objective: In this review, the authors aim to describe the multitude of uses for BoNT in the dermatologic field. Materials and Methods: This manuscript was designed as a retrospective review of the on- and off-label applications of BoNT in dermatology.Results: In addition to treatment of rhytides, BoNT has been shown to decrease rosacea, menopause-associated flushing, and facial sebum production, while improving patient confidence in their appearance. Furthermore, BoNT has been successfully used to treat primary hyperhidrosis, hair loss, aberrant scarring, Raynaud’s phenomenon-associated vasospasm, as well as a variety of skin diseases. Side effects of BoNT include pain or discomfort associated with injections during treatment, bruising, asymmetry, and swelling. Patients are generally satisfied with clinical results after BoNT treatment. Conclusion: Dermatologists should be aware of all on- and off-label applications of BoNT to provide patients with timely and appropriate medical care. Further research must be completed to fully characterise the safety and use of BoNT for off-label purposes.

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Section: Bullous Skin Diseasementioning

confidence: 99%

Botulinum Toxins in Medical and Cosmetic Dermatology

2021

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“…It was proposed that other painful cutaneous conditions with and without neurological involvements, such as anal fissures, leg ulcers, lichen simplex, postherpetic neuralgia and notalgia paraesthetica, might benefit from BoNT therapy . BoNT/A has also shown therapeutic activity in patients with linear IgA bullous dermatosis, lichen simplex, alopecia areata, androgenetic alopecia, facial erythema and flushing (reviewed in Campanati et al . ) and various forms of itch in human skin (Table ) …”

Section: Clinical Applications Of Botulinum Neurotoxinsmentioning

confidence: 99%

The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond

Grando

Zachary

2018

Br J Dermatol

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There is growing evidence that botulinum neurotoxins (BoNTs) exhibit biological effects on various human cell types with a host of associated clinical implications. This review aims to provide an update on the non-neuronal and nonmuscular effects of botulinum toxin. We critically analysed recent reports on the structure and function of cellular signalling systems subserving biological effects of BoNTs. The BoNT receptors and intracellular targets are not unique for neurotransmission. They have been found in both neuronal and non-neuronal cells, but there are differences in how BoNT binds to, and acts on, neuronal vs. non-neuronal cells. The non-neuronal cells that express one or more BoNT/A-binding proteins, and/or cleavage target synaptosomal-associated protein 25, include: epidermal keratinocytes; mesenchymal stem cells from subcutaneous adipose; nasal mucosal cells; urothelial cells; intestinal, prostate and alveolar epithelial cells; breast cell lines; neutrophils; and macrophages. Serotype BoNT/A can also elicit specific biological effects in dermal fibroblasts, sebocytes and vascular endothelial cells. Nontraditional applications of BoNT have been reported for the treatment of the following dermatological conditions: hyperhidrosis, Hailey-Hailey disease, Darier disease, inversed psoriasis, aquagenic palmoplantar keratoderma, pachyonychia congenita, multiple eccrine hydrocystomas, eccrine angiomatous hamartoma, eccrine sweat gland naevi, congenital eccrine naevus, Raynaud phenomenon and cutaneous leiomyomas. Experimental studies have demonstrated the ability of BoNT/A to protect skin flaps, facilitate wound healing, decrease thickness of hypertrophic scars, produce an anti-ageing effect, improve a mouse model of psoriasiform dermatitis, and have also revealed extracutaneous effects of BoNT arising from its anti-inflammatory and anticancer properties. BoNTs have a much wider range of applications than originally understood, and the individual cellular responses to the cholinergic impacts of BoNTs could provide fertile ground for future studies.

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“…One case study documented treatment of linear immunoglobulin A bullous dermatosis with BoNT-A. 87 The disease was mostly controlled by immunosuppressive drugs, but sweating caused flares of symptoms. Multiple injections of BoNT-A into the axillae not only reduced blistering for up to 6 months, but also improved patient quality of life scores.…”

Section: Medical Developmentsmentioning

confidence: 99%

“…Multiple injections of BoNT-A into the axillae not only reduced blistering for up to 6 months, but also improved patient quality of life scores. 87 …”

Section: Medical Developmentsmentioning

confidence: 99%

New Uses of AbobotulinumtoxinA in Aesthetics

Schlessinger¹,

Gilbert²,

Cohen³

et al. 2017

Aesthetic Surgery Journal

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BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. These may be achieved through use of combinations of BoNT-A with other aesthetic procedures, tailoring the dose of toxin to the patient’s muscle mass or by using novel injection and application techniques. Beyond amelioration of facial lines, encouraging results have been seen with the use of BoNT-A to improve the appearance of hypertrophic and keloid scars and even to prevent them. Studies have been conducted with scars in various parts of the body and further research is ongoing. Dermatological and other medical uses for BoNT-A are also active areas of research. Injections of BoNT-A have been shown to reduce signs and symptoms of acne, rosacea, and psoriasis, to reduce neuromuscular pain, and to bring about significant improvements in a number of rare diseases that are caused or exacerbated by hyperhidrosis. This paper reviews these new uses for BoNT-A, looking at the rationale for their use and discussing the results of published case studies and clinical trials. These areas have shown great promise to date, but more and larger clinical studies will be required before these treatments become a clinical reality. To this end details are also provided of clinical trials currently listed in the main clinical trials database to highlight research areas of particular interest.

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Botulinum Toxin A: An Effective Treatment for Linear Immunoglobulin A Bullous Dermatosis Located in the Axillae

Cited by 9 publications

References 11 publications

Botulinum Toxins in Medical and Cosmetic Dermatology

Botulinum Toxins in Medical and Cosmetic Dermatology

The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond

New Uses of AbobotulinumtoxinA in Aesthetics

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