Consensus proposals for classification of the family Hepeviridae

Smith, Donald B.; Simmonds, Peter; Jameel, Shahid; Emerson, Suzanne U.; Harrison, Tim J.; Meng, Xiang‐Jin; Okamoto, Hiroaki; Poel, Wim van der; Purdy, Michael A.

doi:10.1099/vir.0.000115

Cited by 82 publications

(64 citation statements)

References 29 publications

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“…3, 4) of Orthohepevirus A according to the classification proposed by Smith et al (2014). Based on both ORF1 and ORF2 phylogenies supported by the high bootstrap values, the sequences of the majority of Croatian strains clustered into one of two subgroups: cluster CRO A (CRO VS W, CRO VS D, CRO OB F, CRO BB D, CRO SM W, CRO SM D) and cluster CRO B (CRO BP W, CRO BP D).…”

Section: Sequence Analysismentioning

confidence: 99%

“…To determine the phylogenetic clustering of the obtained sequences, the prototype ORF1 and ORF2 sequences, representing all proposed Orthohepevirus A genotypes (Smith et al 2014) were retrieved from GenBank. Also, similar sequences obtained using BLAST algorithm were included in the analysis.…”

Section: Hev Genotypingmentioning

confidence: 99%

“…The infection is transmitted enterically, mainly by the consumption of contaminated food or water (Yugo and Meng 2013), and ranges from an asymptomatic to a severe course, as described in pregnant women (Navaneethan et al 2008) and immunocompromised patients (Kamar et al 2011;Le Coutre et al 2009). So far, four HEV genotypes (HEV-1 to HEV-4) infecting humans have been recognised within seven genotypes of species A from genus Orthohepevirus according to the classification proposed by Smith et al (2014). HEV-1 and HEV-2 are human specific, while two genetically more diverse genotypes HEV-3 and HEV-4 are reported from both human and animal sources.…”

Section: Introductionmentioning

confidence: 99%

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Distribution and Molecular Characterization of Hepatitis E virus in Domestic Animals and Wildlife in Croatia

et al. 2015

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Hepatitis E is becoming a growing health concern in European countries as an increase of sporadic human cases of unknown origin has been recorded lately. Its causative agent, Hepatitis E virus (HEV), is known to have zoonotic potential and thus the role of domestic and wild animals in the chain of viral spread should be considered when investigating risk factors and the epidemiology of the disease. A comprehensive survey based on viral RNA detection was carried out in Croatia including blood, spleen and liver samples originating from 1816 different domestic and wild animals and digestive gland samples from 538 molluscs. A high HEV prevalence was detected in domestic pigs (24.5%) and wild boars (12.3%), whereas cattle, molluscs, ruminant and carnivore wildlife samples tested negative. Molecular characterization of both ORF1 and ORF2 genomic regions confirmed the phylogenetic clustering of the obtained sequences into genotype 3, previously reported in Europe. Furthermore, our results proved the presence of identical sequence variants in different samples, regardless of their origin, age or habitat of the host, suggesting transmission events between domestic swine, as well as between domestic swine and wild boars in the country. Moreover, a close genetic relationship of Croatian animal strains and known human HEV strains from GenBank opens the question of possible cross-species HEV transmission in Croatia, especially in the areas with an intensive swine production.

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Section: Sequence Analysismentioning

confidence: 99%

Section: Hev Genotypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distribution and Molecular Characterization of Hepatitis E virus in Domestic Animals and Wildlife in Croatia

et al. 2015

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“…HEV strains infecting humans are provisionally classified in the genus Orthohepevirus, species Orthohepevirus A, which also includes strains from pig, wild boar, deer, mongoose, rabbit and camel [28]. Of the four recognized mammalian genotypes, genotypes 1 and 2 infect humans exclusively, whereas genotype 3 and 4 strains are found in both humans and animals [29].…”

Section: Introductionmentioning

confidence: 99%

Detection and molecular characterization of zoonotic viruses in swine fecal samples in Italian pig herds

et al. 2015

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Gastrointestinal disease is frequent in pigs, and among the different etiological agents involved, viruses are considered the leading cause of infection in this animal species. Furthermore, about half of the newly identified swine pathogens are viruses, many of which may be transmitted to humans by direct contact or by indirect transmission pathways. In this study, the prevalence of astrovirus (AstV), group A rotavirus (RVA), norovirus (NoV) and hepatitis E virus (HEV) infections in pigs was investigated. During 2012-2014, 242 fecal samples were collected from pigs at different production stages (5 to 220 days old) on eight swine farms located in northern, central and southern Italy. Seven out of eight farms analyzed were positive for AstV, which was detected in 163 out of 242 (67.4%) samples and was the most prevalent virus; 61 of the 163 AstV-positive animals (37.4%) had diarrhea. HEV was detected on six farms and in 45 (18.6%) of the 242 samples analyzed. Twenty-three HEV-infected pigs had diarrhea (51.1%). A lower prevalence was observed for RVA, which was found in 10 of the 242 samples (4.1%) from three positive farms, and diarrhea was present only in six infected pigs (60.0%). No swine samples were found to be positive for NoV. Genetic diversity and phylogenetic relationships of some strains representative of the different viruses detected were investigated, confirming a wide heterogeneity of viral strains circulating among pigs.

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“…HEV includes at least four human-pathogenic genotypes (HEV-G1, -G2, -G3, and -G4) and several subtypes (6). HEV-G1 is hyperendemic in Asia and Africa and frequently causes large outbreaks of acute hepatitis (7).…”

mentioning

confidence: 99%

Challenges in research and management of hepatitis E virus infection in Cuba, Mexico, and Uruguay

Realpe

Montalvo

Mirazo

et al. 2018

Rev Panam Salud Publica

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Consensus proposals for classification of the family Hepeviridae

Cited by 82 publications

References 29 publications

Distribution and Molecular Characterization of Hepatitis E virus in Domestic Animals and Wildlife in Croatia

Distribution and Molecular Characterization of Hepatitis E virus in Domestic Animals and Wildlife in Croatia

Detection and molecular characterization of zoonotic viruses in swine fecal samples in Italian pig herds

Challenges in research and management of hepatitis E virus infection in Cuba, Mexico, and Uruguay

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