25P Promising immuno-oncological role of rosemary against breast cancer through altering miR-17-5p, MALAT-1, H19 and tumour microenvironment

Abstract

expression of miR-17-5p mimics resulted in a repression of STAT3, H19 and induction of ULBP2 levels. Knocking down of STAT3 repressed H19 levels and induced ULBP2. Consquently, H19 siRNAs induced ULBP2 levels.Conclusions: This study showed miR-17-5p/STAT3/H19 as a vital regulatory axis for ULBP2 in BC cells. The current evidence also supports the nomination of miR-17-5p as a potential therapeutic option for BC patients counteracting the immune intolerance phenomena exhibited by BC cells.Legal entity responsible for the study: German University in Cairo.

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

“…This was supported by evidence that was reported by Li et al that MALAT-1 could directly sponge miR-34a in melanoma cells [54] and directly target miR-17–5p in macrophages [55] . Nonetheless, our group and others have recently proven the tumor suppressor effects of both miRNAs in TNBC cells [ 28 , 56 ] and their possible immunomodulatory role in several malignancies [ 57 , 58 ]. To confirm our hypothesis, expression profiling of the selected miRNAs was performed in the same cohort of BC patients recruited in the current study.…”