Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization

Calixto, Giovana Maria Fioramonti; Yoshii, Ana Carolina; Silva, Hilris Rocha e; Cury, Beatriz Stringhetti Ferreira; Chorilli, Marlus

doi:10.3109/10837450.2014.882941

Cited by 106 publications

(103 citation statements)

References 41 publications

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“…Texture profile analysis (TPA) was carried out by using a TA-XTplus texture analyzer (Stable Micro Systems, Surrey, UK) as described by Calixto et al 40 The samples were weighed (7 g), placed in 50 mL centrifuge tubes (Falcon; BD Biosciences ® , Franklin Lakes, NJ, USA), and centrifuged (Sorval TC 6 centrifuge; Du Pont, Newtown, CT, USA) to remove the air bubbles present in the samples. Then, the samples were allowed to stand for 24 hours until analysis.…”

Section: Texture Profile Analysismentioning

confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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Section: Texture Profile Analysismentioning

confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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“…Seven replicates were analyzed at 37°C±0.5°C. [29][30][31] In vitro cytotoxic activity Vero line (ATCC ® CCL-81™) was used to determine cytotoxicity (IC 50 ). The cells were maintained in flasks with a 12.50 cm 2 surface area containing 10 mL of culture medium incubated at 37°C in 5% CO 2 .…”

Section: Bioadhesion Assaymentioning

confidence: 99%

Nanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium sp.

Bonifácio¹,

Ramos²,

Silva³

et al. 2015

IJN

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The genus Astronium (Anacardiaceae) includes species, such as Astronium fraxinifolium , Astronium graveolens , and Astronium urundeuva , which possess anti-inflammatory, anti-ulcerogenic, healing, and antimicrobial properties. Nanostructured lipid systems are able to potentiate the action of plant extracts, reducing the required dose and side effects and improving antimicrobial activity. This work aims to evaluate a nanostructured lipid system that was developed as a strategy to improve the anti- Candida albicans activity of hydroethanolic extracts of stems and leaves from Astronium sp. The antifungal activity against C. albicans (ATCC 18804) was evaluated in vitro by a microdilution technique. In addition to the in vitro assays, the Astronium sp. that showed the best antifungal activity and selectivity index was submitted to an in vivo assay using a model of vulvovaginal candidiasis infection. In these assays, the extracts were either used alone or were incorporated into the nanostructured lipid system (comprising 10% oil phase, 10% surfactant, and 80% aqueous phase). The results indicated a minimal inhibitory concentration of 125.00 µg/mL before incorporation into the nanostructured system; this activity was even more enhanced when this extract presented a minimal inhibitory concentration of 15.62 µg/mL after its incorporation. In vivo assay dates showed that the nanostructure-incorporated extract of A. urundeuva leaves was more effective than both the unincorporated extract and the antifungal positive control (amphotericin B). These results suggest that this nanostructured lipid system can be used in a strategy to improve the in vitro and in vivo anti- C. albicans activity of hydroethanolic extracts of Astronium sp.

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“…PAA is a water soluble, biodegradable [18–24] and pharmaceutically safe polymer that considerably employed in a wide range of medicinal applications [19]. According to Calixto [25], PAA produces a hydrogel that is promising for topical drug delivery, allowing close contact with a biological substrate as well as enhancement of the local concentration gradient, where both factors may improve the biological performance of the drugs. In the last decade, various researchers have focused on developing new drug-carrier systems comprising nanogels based on PAA materials [26–28].…”

Section: Introductionmentioning

confidence: 99%

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

Alghamdi

Alsolami

Saeed

et al. 2018

Designed Monomers and Polymers

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A series of poly(acrylic acid)/poly(methyl vinyl ketone) (PAA/PMVK) blends with different compositions were prepared by the solvent casting method. The miscibility of this pair of polymers was investigated by differential scanning calorimetry(DSC), Fourier transform infra-red (FTIR) and X-Ray diffraction (XRD) techniques. An in-vitro cytotoxicity test of the drug-carrier system via MTT (3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed no significant cytotoxic effects at concentrations up to 100 µg· ml−1. The STX/PAA-50 drug carrier systems were also prepared by solvent casting of solutions containing the sulfamethoxazole (STX) used as drug model and PAA/PMVK blend in N.N-dimethylformamide then crosslinked with acidified ethylene glycol. The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated. According to the total gastrointestinal transit time estimated by Belzer, the estimate distribution of STX released in the different organs indicated that the performance is obtained with the drug – carrier-system containing equal ratios of polymer and 10 wt% of STX (STX-10/PAA-50).

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Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization

Abstract: The set of results demonstrated that these hydrogels are promising to be used as topical controlled drug delivery system.

Cited by 106 publications

References 41 publications

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Nanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium sp.

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

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Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization

Abstract: The set of results demonstrated that these hydrogels are promising to be used as topical controlled drug delivery system.

Cited by 106 publications

References 41 publications

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Nanostructured lipid system as a strategy to&nbsp;improve the anti-Candida albicans activity of&nbsp;Astronium sp.

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

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Nanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium sp.