Plasma genistein and risk of prostate cancer in Chinese population

Abstract

ObjectivesGenistein is one of the main soy isoflavones in our daily diet. There were studies proving that high-dietary intake of genistein may relate to the low morbidity and mortality of prostate cancer (PCa) in the Asian population. Since there were few studies of plasma genistein level in the Chinese population, we performed this study to preliminarily evaluate the associations among plasma genistein, epidemiologic factors and PCa in a Chinese population.MethodsBetween 2012 and 2013, 100 men over the age of 40 underwent prostate biopsy for PCa at Huashan Hospital, Shanghai, China. Clinical information, epidemiologic information and blood samples were collected prior to biopsy for each patient. All patients underwent 10-core ultrasound-guided transperineal prostate biopsy, and the pathology results were collected after biopsy. We measured the plasma genistein concentration of the blood samples and analyzed the results along with the clinical and epidemiologic information.ResultsAmong the 100 patients, 46 (46.0 %) were diagnosed with PCa. The median plasma genistein concentration of non-PCa patients (728.6 ng/ml) was significantly higher than that of PCa patients (513.0 ng/ml) (P < 0.05). In the univariate analysis, we found that age and smoking history were related to PCa (P < 0.05). In the multivariate analysis, we found that age, smoking history and plasma genistein were related to PCa (P < 0.05). The age-adjusted odds ratio of PCa risk comparing plasma genistein level above median to that below median was 0.31 (95 % CI 0.13–0.71).ConclusionOur study suggested that high concentration of plasma genistein level may contribute to the low incidence of prostate cancer in Chinese population.

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

“…Of the 2531 articles that were screened by abstract, 39 articles were found to contain potentially relevant information and were evaluated by full text review. Upon reviewing the full text articles for the aforementioned inclusion criteria, 30 articles were included in the final analysis [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. Of these 30 articles, 24 [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 ,…”

“…Of the 30 articles included for analysis, fifteen [ 28 , 29 , 30 , 32 , 34 , 37 , 38 , 39 , 41 , 42 , 47 , 48 , 49 , 52 , 56 ] articles were case-control studies, eight [ 27 , 31 , 33 , 36 , 43 , 45 , 46 , 53 ] articles were cohort studies, and seven [ 35 , 40 , 44 , 50 , 51 , 54 , 55 ] articles were nested case-control studies (NCC). The total number of study participants included was 266,699, and the total number of PCa cases reported was 21,612.…”

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma

“…Genistein (5,7,4′-trihydroxyisoflavone), a soybean-derived isoflavone, has been identified as a potential cause for the low incidence of certain types of tumors, including lung cancer [ 164 ], breast cancer [ 165 ], gastric cancer [ 166 ], colon cancer [ 167 ], HCC [ 168 ], and prostate cancers [ 169 ]. Genistein can exert its chemopreventive activities in each stage of multistep carcinogenesis through inhibiting tumor cell proliferation, inducing tumor cell differentiation, and triggering cell cycle arrest and apoptosis in some cell types [ 170 , 171 ].…”

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

“…Accumulating epidemiological evidence has highlighted a geographical basis for PCa incidence, and isoflavone consumption may be related to this phenomenon. Indeed, PCa is more common in Western than Asian populations, and several trials have demonstrated that soy derivatives genistein and daidzein can prevent the development and progression of this tumor in Japanese and Chinese men [293][294][295][296]. On the contrary, the data collected in European patients are still contradictory.…”