Prognostic significance of preoperative platelet count in patients with gallbladder cancer

Zhang, Lingqiang; Mu, Yiping; Li, Jianbo; Xu, Xiayu; Pang, Qing; Sun, Liankang; Zhang, Xing; Dong, Shunbin; Wang, Lin; Liu, Chang

doi:10.3748/wjg.v21.i17.5303

Cited by 17 publications

(18 citation statements)

References 30 publications

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“…On the other hand, there are no common invasive behaviors that predict prognosis in all BTC patients. In recent studies with 200 or more BTC patients, the independent prognostic factors for nodal metastasis were tumor size, vascular invasion, and intrahepatic metastasis in ICC, differentiation, liver invasion, and pancreas invasion in ECC, TNM stage in GB, and perineural invasion in Va . There were no common independent prognostic factors for nodal metastasis in all BTC patients.…”

Section: Discussionmentioning

confidence: 96%

The prognostic impact of differentiation at the invasive front of biliary tract cancer

Okubo

Mitsunaga

Kato

et al. 2018

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 96%

The prognostic impact of differentiation at the invasive front of biliary tract cancer

Okubo

Mitsunaga

Kato

et al. 2018

Journal of Surgical Oncology

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“…Due to the low incidence of GBC, few studies have examined the correlations between inflammation-related factors and GBC prognosis. The inflammation-related factors explored in previous studies include platelet count (PLT)[ 35 ], platelet to lymphocyte ratio (PLR)[ 32 , 33 ], neutrophil to lymphocyte ratio (NLR)[ 36 , 37 ] and plasma fibrinogen level[ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al[ 35 ] showed that a PLT > 178 × 10 9 /L was significantly correlated with worse prognosis of GBC (HR = 1.541, 95%CI: 1.038-2.287, P = 0.032) and identified 178 × 10 9 /L as the optimal cut-off value (AUC = 0.798, 95%CI: 0.737-0.858, sensitivity: 0.746, specificity: 0.722). The prognostic accuracy of PLT for GBC was higher than that of plasma fibrinogen in our study (AUC = 0.735, 95%CI: 0.654-0.816, sensitivity: 0.709, specificity: 0.721).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

Zhang

Yang

et al. 2018

WJG

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AIMTo investigate the prognostic value of the combination of preoperative plasma fibrinogen and CA199 in patients with gallbladder carcinoma (GBC).METHODSThe clinicopathological data of 154 GBC patients were retrospectively reviewed after surgery. A receiver operating characteristic (ROC) curve was plotted to verify the optimum cut-off values for plasma fibrinogen and CA199. Univariate and multivariate survival analyses were performed to identify the factors associated with GBC prognosis. Based on the HRs calculated via multivariate survival analyses, patients with elevated plasma fibrinogen and CA199 levels were allocated a score of 2.1; those with an elevated plasma fibrinogen level only were allocated a score of 1, those with an elevated CA199 level only were allocated a score of 1.1, and those with neither of these abnormalities were allocated a score of 0.RESULTSROC curve analysis showed that the optimum cut-off values for preoperative plasma fibrinogen and CA199 were 3.47 g/L and 25.45 U/mL, respectively. Multivariate analysis indicated that elevated preoperative plasma fibrinogen and CA199 levels were significantly correlated with worse overall survival (OS) (HR = 1.711, 95%CI: 1.114-2.627, P = 0.014, and HR = 1.842, 95%CI: 1.111-3.056, P = 0.018). When we combined these two parameters, the area under the ROC curve increased from 0.735 (for preoperative plasma fibrinogen only) and 0.729 (for preoperative CA199 only) to 0.765. When this combined variable was added to the multivariate analysis, the combination of plasma fibrinogen and CA199 (P < 0.001), resection margin (P < 0.001) and TNM stage (P = 0.010) were independent prognostic factors for GBC.CONCLUSIONThe combination of plasma fibrinogen and CA199 may serve as a more efficient independent prognostic biomarker for postoperative GBC patients than either parameter alone.

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“…Another study performed by Chiu, who developed a quality of life predictive model after surgical resection of HCC, also considered GPR an independent prognostic factor[ 9 ]. According to evidence that both gamma-glutamyl transferase (GGT)[ 10 ] and platelet count (PLT)[ 11 ] are proposed prognostic predictors of various cancers, GPR is also a potential clinical predictor of GBC; however, the relationship between GPR and prognosis and outcomes in patients with GBC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

γ-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma

Sun¹,

Guan²,

Xu³

et al. 2020

WJGO

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BACKGROUND Gallbladder carcinoma (GBC) carries a poor prognosis and requires a prediction method. Gamma-glutamyl transferase–to–platelet ratio (GPR) is a recently reported cancer prognostic factor. Although the mechanism for the relationship between GPR and poor cancer prognosis remains unclear, studies have demonstrated the clinical effect of both gamma-glutamyl transferase and platelet count on GBC and related gallbladder diseases. AIM To assess the prognostic value of GPR and to design a prognostic nomogram for GBC. METHODS The analysis involved 130 GBC patients who underwent surgery at Peking Union Medical College Hospital from December 2003 to April 2017. The patients were stratified into a high- or low-GPR group. The predictive ability of GPR was evaluated by Kaplan–Meier analysis and a Cox regression model. We developed a nomogram based on GPR, which we verified using calibration curves. The nomogram and other prognosis prediction models were compared using time-dependent receiver operating characteristic curves and the concordance index. RESULTS Patients in the high-GPR group had a higher risk of jaundice, were older, and had higher carbohydrate antigen 19-9 levels and worse postoperative outcomes. Univariate analysis revealed that GPR, age, body mass index, tumor–node–metastasis (TNM) stage, jaundice, cancer cell differentiation degree, and carcinoembryonic antigen and carbohydrate antigen 19-9 levels were related to overall survival (OS). Multivariate analysis confirmed that GPR, body mass index, age, and TNM stage were independent predictors of poor OS. Calibration curves were highly consistent with actual observations. Comparisons of time-dependent receiver operating characteristic curves and the concordance index showed advantages for the nomogram over TNM staging. CONCLUSION GPR is an independent predictor of GBC prognosis, and nomogram-integrated GPR is a promising predictive model for OS in GBC.

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Prognostic significance of preoperative platelet count in patients with gallbladder cancer

Abstract: PLT is closely correlated with GBC prognosis and could be used to identify the population with a poorer prognosis after surgery.

Cited by 17 publications

References 30 publications

The prognostic impact of differentiation at the invasive front of biliary tract cancer

The prognostic impact of differentiation at the invasive front of biliary tract cancer

Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

γ-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma

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