Study of the Effects of Cyclooxygenase-2 Inhibitor on the Promotion of Hepatic Tumorigenesis in Rats Fed a High Fat Diet

Hamzawy, Magda; Elsaid, Laila; Shams, Asmaa; Rashid, Laila; Mahfouz, Soheir; Sharawy, Nivin

doi:10.1016/j.jceh.2014.12.010

Cited by 10 publications

(4 citation statements)

References 39 publications

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“…In addition, EGb increased mRNA expression of Cox2 in mice with liver tumors. Since Cox2 is involved in liver disease and hepatic tumorigenesis [ 44 – 46 ], induction of Cox2 by EGb in liver with tumors in the current study could be an important indicator of tumor-promoting effects from EGb. Together with the contradictory data from mice without tumors (Normal group), these confirmed the previous published data showing anti-oxidative and anti-apoptotic effects of EGb.…”

Section: Discussionmentioning

confidence: 96%

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Wang¹,

Wu²,

Lezmi³

et al. 2017

BMC Complement Altern Med

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BackgroundMetastasis refers to the spread of a primary tumor cell from the primary site to other locations in the body and it is generally associated with the severity of a tumor. Extract of Ginkgo biloba (EGb) contains various bioactive compounds and it exerts beneficial effects including improvements in brain function and reduced risk of cardiovascular diseases. On the other hand, increased risk of thyroid and liver cancers by EGb have been reported in animals.MethodsA colon cancer metastasis model was established using intrasplenic injection of a human colon cancer cell line, SW620-luc in athymic mice to investigate the potential impact of EGb on colon cancer progression. After tumor establishment, EGb was intraperitonically injected daily for 5 wks.ResultsEGb significantly increased the rate of metastasis in mouse liver and decreased the number of necrotic and apoptotic cells in the metastatic liver when compared to the control. Meanwhile, EGb significantly induced proliferation of tumor cells in the metastatic liver, indicated by increased staining of Ki67 and H3S10p. mRNA expression of genes involved in cell cycle, metastasis, apoptosis, and oxidative stress were altered by EGb treatment in livers with tumors. Moreover, EGb activated the stress-responsive MAPK pathways in the liver with metastatic tumors.ConclusionsEGb exacerbated liver metastasis in a mouse colon cancer metastasis model. This is potentially due to the increased tumor cell proliferation involving stimulated MAPK pathways.Electronic supplementary materialThe online version of this article (10.1186/s12906-017-2014-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 96%

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Wang¹,

Wu²,

Lezmi³

et al. 2017

BMC Complement Altern Med

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“…Overexpression of COX-2 and PGE2 receptors is observed in most tumor types, including HCC ( Koga et al, 1999 ; Kondo et al, 1999 ; Shiota et al, 1999 ; Sung et al, 2004 ; Breinig et al, 2008 ; Zang et al, 2017 ) and is further induced when coupled with HFD ( Koga et al, 1999 ; Hamzawy et al, 2015 ). Expressions of COX2 also correlates with the differentiation status of liver cancer ( Koga et al, 1999 ; Kondo et al, 1999 ; Shiota et al, 1999 ; Sung et al, 2004 ) where high COX-2 expression is associated with lymph vascular invasion and distant metastasis with poor 5-year survival ( Tai et al, 2019 ).…”

Section: Biological Functions Of Oxylipins In Liver Disease and Cance...mentioning

confidence: 99%

“…Consistently, ectopic expression of COX-2 in the livers of transgenic mice was sufficient to induce spontaneous HCC development ( Chen et al, 2017 ), though other studies show preneoplastic lesions with minor contribution to the malignant transformation to HCC ( Llorente Izquierdo et al, 2011 ). Further, inhibition of COX-2 attenuates HCC growth in animal models ( Hamzawy et al, 2015 ; Ali et al, 2022 ) and celecoxib dose-dependently reduce tumor weight ( Cui et al, 2005 ; Li et al, 2016 ). These genetic and pharmacological studies indicate a pro-tumor role of COX-2 and its metabolite in liver cancer progression ( Figure 4 ).…”

Section: Biological Functions Of Oxylipins In Liver Disease and Cance...mentioning

confidence: 99%

Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development

et al. 2023

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Liver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver macrophages play important roles in orchestrating the inflammatory response. During this process, bioactive lipids produced by hepatocytes and macrophages mediate the inflammatory responses by acting as pro-inflammatory factors, as well as, playing roles in the resolution of inflammation conditions. Here, we review the literature discussing the roles of bioactive lipids in acute and chronic hepatic inflammation and progression to cancer.

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“…Another known model of NASH is the use of a high-fat diet (HFD), which induces NASH and progresses to HCC (33,34) . Also, the combination of stimuli to reduce the time of appearance of HCC, such as the combination of CCl4 and HFD for 24 weeks, recapitulates the progressive stages of NASH and HCC (35) .…”

Section: Diet and Combination With Chemical Agentsmentioning

confidence: 99%

Preclinical Models of Liver Câncer

GALVÃO,

TRALDI,

ARAÚJO

et al. 2023

Arq. Gastroenterol.

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Background: This manuscript provides an overview of liver carcinogenesis in murine models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Objective: A review through MEDLINE and EMBASE was performed to assess articles until August 2022. Methods: Search was conducted of the entire electronic databases and the keywords used was HCC, CCA, carcinogenesis, animal models and liver. Articles exclusion was based on the lack of close relation to the subject. Carcinogenesis models of HCC include HCC induced by senescence in transgenic animals, HCC diet-induced, HCC induced by chemotoxicagents, xenograft, oncogenes, and HCC in transgenic animals inoculated with B and C virus. The models of CCA include the use of dimethylnitrosamine (DMN), diethylnitrosamine (DEN), thioacetamide (TAA), and carbon tetrachloride (CCl4). CCA murine models may also be induced by: CCA cells, genetic manipulation, Smad4, PTEN and p53 knockout, xenograft, and DEN-left median bile duct ligation. Results: In this review, we described different murine models of carcinogenesis that reproduce the key points for HCC and CCA genesis allowing a better understanding of its genetic, physiopathological, and environmental abnormalities. Conclusion: Each model has its advantages, disadvantages, similarities, and differences with the corresponding human disease and should be chosen according to the specificity of the study. Ultimately, those models can also be used for testing new anticancer therapeutic approaches.

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Study of the Effects of Cyclooxygenase-2 Inhibitor on the Promotion of Hepatic Tumorigenesis in Rats Fed a High Fat Diet

Cited by 10 publications

References 39 publications

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development

Preclinical Models of Liver Câncer

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