A case of conjoined twins after a transfer of a multinuclear embryo

Mankonen, Harri; Seikkula, Jaana; Järvenpää, Tuija; Jokimaa, Varpu

doi:10.1002/ccr3.208

Cited by 9 publications

(3 citation statements)

References 48 publications

(60 reference statements)

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“…Embryos that blastomere containing more than one single interphase nucleus on Day-2 or Day-3 are known as MNB [5] .The causative factors may be response to ovarian stimulation and intrafollicular hypoxia disturbing oocyte spindle organization during the oocyte retrieval process [8,9] .MNB may result from insu cient culture medium or from cooling of the oocyte during manipulation leading to alterations of the cytoskeleton [10,11] .Previous studies demonstrated that embryos with MNB had a decreased implantation potential, an increased level of chromosome abnormality [12,13,14,15] and an increased risk of spontaneous abortion [5,8,16,17,12,14,15] .Moreover, multinucleated embryos development slower than non-multinucleated embryos [18] .Nevertheless, still had some MNB embryos were able to achieve pregnancies [19,20] and early multinucleation was not directly related to a lower implantation rate [18,21,22] .…”

Section: Discussionmentioning

confidence: 99%

Utilization and Outcome of Abnormal 2PN Human Embryos

Li,

Wang,

Shan

et al. 2023

Preprint

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OBJECTIVE There are not a few embryos derived from abnormal 2PN zygotes or embryo. For patients with non-normal available embryos, whether such embryos are discarded or continue to be transplanted have always been a concern of clinicians. This paper conducts research and analysis on this issue. STUDY DESIGN: This is a retrospective control study. All data collected was based on two IVF center between July 2011 and July 2021. We analyzed the clinical pregnancy rate and live birth rate derived from four kinds of abnormal 2PN embryos transplanted at the cleavage phases or blastocyst phases over the past 10 years. These data were statistically analyzed compared with the normal 2PN control group. RESULTS Among 50271 zygotes or embryos obtained from oocyte retrieval, 2PN, 0PN, 1PN,MNB and SERa accounted for 58.02%, 13.77%, 4.93%, 0.78% and 0.54%, respectively. After the transplantation of 3250 frozen-thawed cleavage embryos included in the study criteria, the clinical pregnancy rates of 2PN, 0PN, 1PN,MNB and SERa were: 48.6%, 18.6%, 12.4%, 25.5%, 10.7%, and the live birth rates were: 41.9%, 13.1%, 10.0%, 20.8%, 8.0%, respectively. After the transplantation of 3618 frozen-thawed blastocysts included in the study criteria, the clinical pregnancy rates of 2PN, 0PN, 1PN,MNB and SERa were: 59.4%, 48.3%, 47.6%, 51.7%, 53.1%, and the live birth rates were: 50.3%, 38.9%, 40.1%, 43.2%, 42.9%, respectively. Further analysis showed that the live birth rate of0PN, 1PN,MNB and SERacleavage embryo transplantation was only 19.1%-49.6%of normal 2PN cleavage embryo, while the live birth rate of 0PN, 1PN,MNB and SERablastocyst transplantation was 77.3%-85.9% of normal 2PN blastocyst. CONCLUSION When no normal 2PN embryos are available for transplantation, abnormal 2PN embryos are transplanted after being cultured to the blastocyst and the live birth rate close to that of a normal 2PN embryo can be obtained.

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Section: Discussionmentioning

confidence: 99%

Utilization and Outcome of Abnormal 2PN Human Embryos

Li,

Wang,

Shan

et al. 2023

Preprint

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“…Currently, only around 15 cases of post-IVF/ICSI conjoined twins are reported in the literature and no extensive studies are available in this lineage. 4 Conjoined twinning can either be due to ventral or dorsal fusion. Ventral fusion can be lateral, rostral or caudal, and dorsal fusion can be craniopagus, rachipagus or pygopagus.…”

Section: Postnatal Imagingmentioning

confidence: 99%

Diprosopus Tetraophthalmus with Double Outlet Right Ventricle, Congenital Diaphragmatic Hernia, and Duplicated Gall Bladder on Targeted Antenatal Ultrasound with Postnatal Ultrasound and Computed Tomography Correlation

Devarajan,

Puthiyakam,

Rubalakshmi

et al. 2023

International Journal of Infertility &Amp; Fetal Medicine

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Diprosopus or craniofacial duplications are the rarest forms of conjoined twins. The reported incidence in various literature is 1,80,000 to 15 million births (0.4% of conjoined twins. 1 Due to the rarity of the condition, the exact pathogenesis and genetics behind are yet to be unwound. In this article, we have attempted to understand the anatomical delineations better using fetal magnetic resonance imaging (MRI) and postnatal computed tomography (CT) with three-dimensional (3D) reconstructions. case descriptionA 26-year-old primi came to us for a targeted imaging for fetal anomalies (TIFFA) scan. She was married for 7 years and was diagnosed to have primary infertility. The couple decided to proceed with the artificial reproduction technique (ART) and underwent intracytoplasmic sperm injection (ICSI) with transfer of three embryos. The nuchal translucency (NT) and the first anomaly scans were done elsewhere. NT scan done at 12 2/7 weeks gestation revealed a large

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“…Finnish investigators recently reported the first known case of conjoined twins conceived after transfer of a multinuclear embryo (Mankonen et al, 2015). The mother, 33 years of age and healthy, was referred to the clinic because of her partner's infertility.…”

Section: Embryo Transfer and Conjoined Twinningmentioning

confidence: 99%

Twin Classics: Research That Always Inspires/Twin Studies: Elder Twin Relationships; Superfecundated Twinning in Chimpanzees; Conjoined Twinning and Embryo Transfer; Reduced Frequency of In Vitro Multiples/Professional and Human Interest: First Identical Twin Renal Transplant; Identical Triplet Wedding; Spanakos Twins: Boxers; Twins in Space; Political Twins

Segal

2015

Twin Res Hum Genet

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Ten classic works in twin research are described. These volumes are rich in data, interpretation, and impact, and contain life history material that adds depth and dimension to the quantitative findings. Next, research on social relationships in older twins, superfecundated twinning in chimpanzees; effects of embryo transfer on conjoined twinning and the reduced frequency of in vitro multiples is reviewed. Finally, there has been considerable public interest surrounding the first identical twin renal transplant, an identical triplet wedding; identical twin boxers, a twin living in space, and a politically active twin pair.

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A case of conjoined twins after a transfer of a multinuclear embryo

Cited by 9 publications

References 48 publications

Utilization and Outcome of Abnormal 2PN Human Embryos

Utilization and Outcome of Abnormal 2PN Human Embryos

Diprosopus Tetraophthalmus with Double Outlet Right Ventricle, Congenital Diaphragmatic Hernia, and Duplicated Gall Bladder on Targeted Antenatal Ultrasound with Postnatal Ultrasound and Computed Tomography Correlation

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