Inflammatory Serum Proteins Are Severely Altered in Metastatic Gastric Adenocarcinoma Patients from the Chinese Population

Wang, Jiangnan; Ma, Rong; Sharma, Ashok; He, Ming-Fang; Xue, Jing; Wu, Jianzhong; Dun, Boying; Li, Gang; Wang, Xiaoxiao; Ji, Minjun; She, Jin‐Xiong; Tang, Jinhai

doi:10.1371/journal.pone.0123985

Cited by 9 publications

(11 citation statements)

References 50 publications

(51 reference statements)

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“…Similarly, Baba et al [6], showed that CRP levels per se are a prognostic factor in cases of Stage IV gastric cancer. In another study investigating the roles of inflammatory proteins in gastric cancer, Wang et al, found that elevated CRP levels were only associated with metastatic disease and, contrary to the above referred studies, elevated CRP levels were not related to Stage I, Stage II and Stage III disease [5]. Moreover, increased CRP levels were associated with male gender in that study, but no such association was established with mean age; a finding that is contradictory to ours [26].…”

Section: Discussioncontrasting

confidence: 67%

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Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Üreyen¹

2016

J Surg Surgical Res

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Background: The impact of systemic inflammatory response on carcinogenesis and tumor progression has recently gained much attention. Biochemical markers such as albumin, pre-albumin and C-reactive protein (CRP) are currently used to predict prognosis in several cancer types, and the usefulness of these biomarkers in gastric cancer has become an emerging topic of research. The present study aims to assess the correlation between tumor stage and the levels of pre-albumin, albumin and CRP in patients who underwent surgery for gastric cancer.Methods: Albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer in our division, were prospectively recorded and retrospectively evaluated. Age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels were recorded. Albumin levels lower than 3.5 mg/dL and pre-albumin levels lower than 20 mg/dL were considered to be below the normal range. CRP levels higher than 5 mg/L were considered to be elevated. Patients with another focus of inflammation were excluded from the study.Results: A total number of 41 patients, 32 (78%) men and 9 (22%) women, were included in the study. Albumin levels were significantly associated with the age (p=0.010). There was no significant correlation between disease stage, gender, presence of metastatic lymph nodes and albumin levels (p>0.05). There was a significant correlation between the TNM stage and pre-albumin levels (P=0.014). No significant correlation was demonstrated between pre-albumin levels and the other parameters (P>0.05). The independent variables were not found to be significantly different between the groups with normal and elevated CRP levels (p>0,05) Conclusions:The present study showed that the patients with lymph node metastasis and advanced stage gastric cancer more frequently have decreased levels of albumin and pre-albumin, and elevated levels of CRP. Decreased pre-albumin level was found to be associated with the TNM stage. The albumin levels were found to be decreasing by age. Although we failed to demonstrate a statistically correlation with albumin and CRP, preoperative albumin, pre-albumin and CRP levels may be useful to predict prognosis of patients with gastric cancer.

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Section: Discussioncontrasting

confidence: 67%

“…Moreover, such biomarkers can help to establish the risk of metastasis or recurrence of the disease. Serum amyloid A, C-reactive protein (CRP) and α1-acid glycoprotein may be listed among the inflammatory markers that are associated with malignant conditions [5].…”

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confidence: 99%

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Üreyen¹

2016

J Surg Surgical Res

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“…We observed that the albuminomes from the six studies included 28 known low-abundance proteins (LAPs) with concentrations below 100 ng/mL (based on published data) (Supplementary Table S5 ) 49 – 53 . Twelve of these LAPs were identified exclusively in our study, and included candidate cancer biomarkers, such as CDH5, VCAM1, and IGFBP3 50 , 54 – 57 . IGFBP3 could also be applied to assessment of preoperative depression risk of high-grade glioma patients 58 .…”

Section: Resultsmentioning

confidence: 99%

Proteomic and network analysis of human serum albuminome by integrated use of quick crosslinking and two-step precipitation

Liu

Wang

et al. 2017

Sci Rep

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Affinity- and chemical-based methods are usually employed to prepare human serum albuminome; however, these methods remain technically challenging. Herein, we report the development of a two-step precipitation (TSP) method by combined use of polyethylene glycol (PEG) and ethanol. PEG precipitation was newly applied to remove immunoglobulin G for albuminome preparation, which is simple, cost effective, efficient and compatible with downstream ethanol precipitation. Nonetheless, chemical extraction using TSP may disrupt weak and transient protein interactions with human serum albumin (HSA) leading to an incomplete albuminome. Accordingly, rapid fixation based on formaldehyde crosslinking (FC) was introduced into the TSP procedure. The developed FC-TSP method increased the number of identified proteins, probably by favouring real-time capture of weakly bound proteins in the albuminome. A total of 171 proteins excluding HSA were identified from the fraction obtained with FC-TSP. Further interaction network and cluster analyses revealed 125 HSA-interacting proteins and 14 highly-connected clusters. Compared with five previous studies, 55 new potential albuminome proteins including five direct and 50 indirect binders were only identified by our strategy and 12 were detected as common low-abundance proteins. Thus, this new strategy has the potential to effectively survey the human albuminome, especially low-abundance proteins of clinical interest.

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“…18 Wang et al, found that elevated CRP levels were only associated with metastatic disease and, contrary to the above referred studies, elevated CRP levels were not related to Stage I, Stage II and Stage III disease. 5 Liu et al, reported a significant correlation of decreased albumin and increased CRP levels with shorter survival, and CRP/albumin ratio as an independent prognostic marker, particularly in cases with Stage I and Stage III disease. 7 The authors proved that this ratio might be related to the nutritional status; but they could not demonstrate its correlation with weight loss and body mass index.…”

Section: Discussionmentioning

confidence: 99%

“…Biomarkers can help in establishing risk of metastasis or recurrence of the disease. 5 Although individual prognostic Systemic inflammatory response and the effects of cytokines associated with inflammation increase CRP levels which, in turn, enhance cancer progression. 6 Biochemical markers such as albumin, pre-albumin and C-reactive protein (CRP) are currently used to predict prognosis in several types of cancer, So present study is aimed to assess the correlation between tumor stage and the levels of pre-albumin, albumin and CRP in patients underwent surgery for gastric cancer.…”

mentioning

confidence: 99%

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

Rao¹,

Phanikumar²,

Kumar³

2017

Int Surg J

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Background: malnutrition and systemic inflammatory response in cancers result in a shorter survival rate, reduced treatment response and a higher rate of complications associated with therapy. Prealbumin, albumin and CRP Levels has utility as a prognostic indicator of cancer survival in cancer. The objective of this study was to albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer were prospectively recorded and retrospectively evaluated.Methods: Study was done for period of 1 year in patients underwent surgery for gastric cancer. Details noted from records are as age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels.Results: A total number of 44 patients, 32 (72.7%) men and 12 (27.7%) women, were included in the study. The mean age was 64.1 (43-89) years. The mean duration of hospital stay was 12.8 (4-46) days. Preoperative albumin levels were below the expected range in 16 (41%) of 44 patients. Mean age of the patients with normal and decreased albumin levels was 62.7±12.8 and 65.3±12.3 years, respectively; albumin levels were insignificantly associated with the age (p = 0.54). When these 16 cases were evaluated in terms of disease stage-3 had 11(68.7%). Preoperative pre-albumin levels were decreased in 23 (53%) of 44 cases. Among the cases with decreased pre-albumin levels, stage 1 and 3 had 5 (21.7%) cases. There was a significant correlation between the TNM stage and pre-albumin levels (P = 0.014). CRP levels were elevated in 19 (43.2%) of 44 cases with CRP. Among these Stage-3 had 8 cases, 4 (42.1%). There was no significant correlation between disease stage, presence of metastatic lymph nodes and albumin levels (p>0.05).Conclusions: Preoperative albumin, pre-albumin and CRP levels can be useful to predict prognosis of patients with gastric cancer.

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Inflammatory Serum Proteins Are Severely Altered in Metastatic Gastric Adenocarcinoma Patients from the Chinese Population

Cited by 9 publications

References 50 publications

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Proteomic and network analysis of human serum albuminome by integrated use of quick crosslinking and two-step precipitation

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

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